有氧糖酵解在皮肤纤维化疾病中的作用研究进展

张丽霞; 胡大海

doi:10.3760/cma.j.cn501225-20230712-00004

有氧糖酵解在皮肤纤维化疾病中的作用研究进展

doi: 10.3760/cma.j.cn501225-20230712-00004

张丽霞,
胡大海^,

空军军医大学第一附属医院全军烧伤中心，烧伤与皮肤外科，西安　　710032

基金项目:

国家自然科学基金面上项目 81372069, 81772071

空军军医大学第一附属医院学科助推计划军事医学基础研究专项 XJZT21J05

详细信息

通讯作者:
胡大海，Email：hudhai@fmmu.edu.cn

计量
- 文章访问数: 40
- HTML全文浏览量: 11
- PDF下载量: 5
- 被引次数: 0
出版历程
- 收稿日期: 2023-07-12

Research advances on the role of aerobic glycolysis in skin fibrosis diseases

Zhang Lixia,
Hu Dahai^,

Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China

Funds:

General Program of National Natural Science Foundation of China 81372069, 81772071

The First Affiliated Hospital of Air Force Medical University Discipline Boosting Program for the Military Medical Basic Research Special Project XJZT21J05

More Information

Corresponding author: Hu Dahai, Email: hudhai@fmmu.edu.cn

摘要

摘要: 皮肤纤维化疾病主要包括增生性瘢痕、瘢痕疙瘩及系统性硬化病等，其主要病理特点为成纤维细胞过度激活和细胞外基质异常沉积。近年来研究表明，有氧糖酵解与皮肤纤维化疾病的发生与发展密切相关，以有氧糖酵解为治疗靶点的药物为皮肤抗纤维化治疗提供了新的思路。该文就有氧糖酵解相关酶和产物在皮肤纤维化疾病发生与发展中的作用及靶向有氧糖酵解治疗皮肤纤维化疾病的药物进行综述。
- 瘢痕 /
- 皮肤疾病 /
- 糖酵解 /
- 纤维化 /
- 成纤维细胞
Abstract: Skin fibrosis diseases mainly include hypertrophic scar, keloid, and systemic sclerosis, etc. The main pathological features are excessive activation of fibroblasts and abnormal deposition of extracellular matrix. In recent years, studies have shown that aerobic glycolysis is closely related to the occurrence and development of skin fibrosis diseases. Drugs targeting aerobic glycolysis has provided new ideas for skin anti-fibrosis treatment. This article reviews the role of enzymes and products related to aerobic glycolysis in the occurrence and development of skin fibrosis diseases and the drugs targeting aerobic glycolysis for the treatment of skin fibrosis diseases.
- Cicatrix /
- Skin diseases /
- Glycolysis /
- Fibrosis /
- Fibroblasts
所有作者均声明不存在利益冲突

HTML全文

1 有氧糖酵解促成纤维细胞活化和增殖的机制

注：α-SMA为α平滑肌肌动蛋白，PDK为丙酮酸脱氢酶激酶，PDH为丙酮酸脱氢酶，TCA为三羧酸循环，TGF-β为转化生长因子β

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