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摘要: 患者创面愈合困难是临床各科室医师均有可能遇到的难题,目前仍然没有很好的解决方案。白藜芦醇是一种天然活性物质,具有抗炎、抗氧化、抗菌及促进血管新生等作用,是潜在的促进创面愈合的药物。然而,白藜芦醇因生物利用度不高等原因,临床应用受限。该文对白藜芦醇促进创面愈合的分子机制及其在创面治疗中的给药方式进行综述,以期为该药的重新开发提供思路。
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关键词:
- 伤口愈合 /
- 药理作用分子作用机制 /
- 白藜芦醇 /
- 慢性难愈性创面 /
- 给药方式
Abstract: The difficulty of wound healing in patients is a difficult problem that doctors in all clinical departments may encounter, and there is still no good solution. Resveratrol is a kind of natural active substance, which has anti-inflammatory, antioxidant, antibacterial, and angiogenesis promoting effects, and is a potential drug to promote wound healing. However, the clinical application of resveratrol is limited due to its low bioavailability. In this review, the molecular mechanism of resveratrol in promoting wound healing and its administration methods in wound treatment were reviewed to provide ideas for the redevelopment of resveratrol. -
[1] ShaitoA,PosadinoAM,YounesN,et al.Potential adverse effects of resveratrol: a literature review[J].Int J Mol Sci,2020,21(6):2084.DOI: 10.3390/ijms21062084. [2] TianB,LiuJ.Resveratrol: a review of plant sources, synthesis, stability, modification and food application[J].J Sci Food Agric,2020,100(4):1392-1404.DOI: 10.1002/jsfa.10152. [3] HuangDD,ShiG,JiangY,et al.A review on the potential of resveratrol in prevention and therapy of diabetes and diabetic complications[J].Biomed Pharmacother,2020,125:109767.DOI: 10.1016/j.biopha.2019.109767. [4] 杨萍.白藜芦醇通过调控信号通路治疗膝骨关节炎的研究进展[J].中草药,2023,54(4):1311-1320.DOI: 10.7501/j.issn.0253-2670.2023.04.032. [5] HouCY,TainYL,YuHR,et al.The effects of resveratrol in the treatment of metabolic syndrome[J].Int J Mol Sci,2019,20(3):535.DOI: 10.3390/ijms20030535. [6] MengT,XiaoD,MuhammedA,et al.Anti-inflammatory action and mechanisms of resveratrol[J].Molecules,2021,26(1):229.DOI: 10.3390/molecules26010229. [7] 刘菁,刘杰,廖鸿雁,等.白藜芦醇预处理对星形胶质细胞氧糖剥夺/再复氧损伤后活化及炎症反应的影响[J].解剖学报,2020,51(3):313-319.DOI: 10.16098/j.issn.0529-1356.2020.03.001. [8] CorrêaMG,AbsyS,TenenbaumH,et al.Resveratrol attenuates oxidative stress during experimental periodontitis in rats exposed to cigarette smoke inhalation[J].J Periodontal Res,2019,54(3):225-232.DOI: 10.1111/jre.12622. [9] GórskaA,KrupaA,MajdaD,et al.Poly(vinyl alcohol) cryogel membranes loaded with resveratrol as potential active wound dressings[J].AAPS PharmSciTech,2021,22(3):109.DOI: 10.1208/s12249-021-01976-1. [10] Fiod RiccioBV,Fonseca-SantosB,Colerato FerrariP,et al.Characteristics, biological properties and analytical methods of trans-resveratrol: a review[J].Crit Rev Anal Chem,2020,50(4):339-358.DOI: 10.1080/10408347.2019.1637242. [11] 胡晓青,刘颖,卿勇.白藜芦醇诱导DT40细胞DNA损伤的机制研究[J].华西药学杂志,2018,33(1):31-33.DOI: 10.13375/j.cnki.wcjps.2018.01.009. [12] HuJ,LiuX,ChiJ,et al.Resveratrol enhances wound healing in type 1 diabetes mellitus by promoting the expression of extracellular vesicle-carried microRNA-129 derived from mesenchymal stem cells[J].J Proteome Res,2022,21(2):313-324.DOI: 10.1021/acs.jproteome.1c00248. [13] DingY,YangP,LiS,et al.Resveratrol accelerates wound healing by inducing M2 macrophage polarisation in diabetic mice[J].Pharm Biol,2022,60(1):2328-2337.DOI: 10.1080/13880209.2022.2149821. [14] LiguoriI,RussoG,CurcioF,et al.Oxidative stress, aging, and diseases[J].Clin Interv Aging,2018,13:757-772.DOI: 10.2147/CIA.S158513. [15] 何丽囡,兰钰茹,贺光明,等.白藜芦醇通过调控HIF-1α/NOX4/ROS通路抑制低氧诱导的大鼠肺动脉平滑肌细胞氧化应激与增殖[J].生理学报,2020,72(5):551-558.DOI: 10.13294/j.aps.2020.0067. [16] KimEN,LimJH,KimMY,et al.Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury[J].Aging (Albany NY),2018,10(1):83-99.DOI: 10.18632/aging.101361. [17] WangN,HanQ,WangG,et al.Resveratrol protects oxidative stress-induced intestinal epithelial barrier dysfunction by upregulating heme oxygenase-1 expression[J].Dig Dis Sci,2016,61(9):2522-2534.DOI: 10.1007/s10620-016-4184-4. [18] ZhuW,DongY,XuP,et al.A composite hydrogel containing resveratrol-laden nanoparticles and platelet-derived extracellular vesicles promotes wound healing in diabetic mice[J].Acta Biomater,2022,154:212-230.DOI: 10.1016/j.actbio.2022.10.038. [19] HuangF,LuX,YangY,et al.Microenvironment-based diabetic foot ulcer nanomedicine[J].Adv Sci (Weinh),2023,10(2):e2203308.DOI: 10.1002/advs.202203308. [20] VestergaardM,IngmerH.Antibacterial and antifungal properties of resveratrol[J].Int J Antimicrob Agents,2019,53(6):716-723.DOI: 10.1016/j.ijantimicag.2019.02.015. [21] 刘柯,石瑾,丁军颖.白藜芦醇调控细菌耐药性研究进展[J].中医学报,2022,37(10):2116-2121.DOI: 10.16368/j.issn.1674-8999.2022.10.378. [22] 苏军华,时东彦,王磊,等.白藜芦醇体外抗肠球菌作用的超微结构变化[J].山东大学学报(医学版),2014,52(2):16-19.DOI: 10.6040/j.issn.1671-7554.0.2013.234. [23] HeZ,HuangZ,ZhouW,et al.Anti-biofilm activities from resveratrol against fusobacterium nucleatum[J].Front Microbiol,2016,7:1065.DOI: 10.3389/fmicb.2016.01065. [24] 江枫,刘丽,张公亮,等.白藜芦醇对蜂房哈夫尼菌生物膜形成的影响[J].大连工业大学学报,2018,37(6):442-445.DOI: 10.19670/j.cnki.dlgydxxb.2018.0603. [25] LiuL,YuJ,ShenX,et al.Resveratrol enhances the antimicrobial effect of polymyxin B on Klebsiella pneumoniae and Escherichia coli isolates with polymyxin B resistance[J].BMC Microbiol,2020,20(1):306.DOI: 10.1186/s12866-020-01995-1. [26] 史旭锋,魏冬,余小平,等.血管内皮生长因子介导的血管新生促进创面愈合的研究进展[J/CD].中华损伤与修复杂志(电子版),2021,16(6):536-538.DOI: 10.3877/cma.j.issn.1673-9450.2021.06.015. [27] BreussJM,AtanasovAG,UhrinP.Resveratrol and its effects on the vascular system[J].Int J Mol Sci,2019,20(7):1523.DOI: 10.3390/ijms20071523. [28] SayinO,MiciliSC,GokerA,et al.The role of resveratrol on full-thickness uterine wound healing in rats[J].Taiwan J Obstet Gynecol,2017,56(5):657-663.DOI: 10.1016/j.tjog.2017.08.015. [29] LinLX,WangP,WangYT,et al.Aloe vera and Vitis vinifera improve wound healing in an in vivo rat burn wound model[J].Mol Med Rep,2016,13(2):1070-1076.DOI: 10.3892/mmr.2015.4681. [30] 付志强,白泽明,陶凯,等.白藜芦醇通过抑制Egr1的表达抑制增生性瘢痕成纤维细胞的生长和迁移[J].中国美容整形外科杂志,2022,33(7):404-407.DOI: 10.3969/j.issn.1673-7040.2022.07.007. [31] YamanI,DericiH,KaraC,et al.Effects of resveratrol on incisional wound healing in rats[J].Surg Today,2013,43(12):1433-1438.DOI: 10.1007/s00595-012-0455-7. [32] KaleciB,KoyuturkM.Efficacy of resveratrol in the wound healing process by reducing oxidative stress and promoting fibroblast cell proliferation and migration[J].Dermatol Ther,2020,33(6):e14357.DOI: 10.1111/dth.14357. [33] ZengG,ZhongF,LiJ,et al.Resveratrol-mediated reduction of collagen by inhibiting proliferation and producing apoptosis in human hypertrophic scar fibroblasts[J].Biosci Biotechnol Biochem,2013,77(12):2389-2396.DOI: 10.1271/bbb.130502. [34] ZhaiXX,DingJC,TangZM.Resveratrol inhibits proliferation and induces apoptosis of pathological scar fibroblasts through the mechanism involving TGF-β1/Smads signaling pathway[J].Cell Biochem Biophys,2015,71(3):1267-1272.DOI: 10.1007/s12013-014-0317-6. [35] JiaY,ShaoJH,ZhangKW,et al.Emerging effects of resveratrol on wound healing: a comprehensive review[J].Molecules,2022,27(19):6736.DOI: 10.3390/molecules27196736. [36] LiuY,XiongW,WangCW,et al.Resveratrol promotes skin wound healing by regulating the miR-212/CASP8 axis[J].Lab Invest,2021,101(10):1363-1370.DOI: 10.1038/s41374-021-00621-6. [37] HuX,ZhangH,ChenZ.Effects of four polyphenols on mouse wound healing and the gene expression profile of resveratrol action[J].Histol Histopathol,2024,39(1):105-116.DOI: 10.14670/HH-18-616. [38] ShinJW,LeeHS,NaJI,et al.Resveratrol inhibits particulate matter-induced inflammatory responses in human keratinocytes[J].Int J Mol Sci,2020,21(10):3446.DOI: 10.3390/ijms21103446. [39] ZhaoCC,ZhuL,WuZ,et al.Resveratrol-loaded peptide-hydrogels inhibit scar formation in wound healing through suppressing inflammation[J].Regen Biomater,2020,7(1):99-107.DOI: 10.1093/rb/rbz041. [40] PangK,LiB,TangZ,et al.Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis[J].Mol Med Rep,2020,22(4):3440-3452.DOI: 10.3892/mmr.2020.11407. [41] 唐志铭,丁继存,荆梦晴,等.白藜芦醇软膏治疗病理性瘢痕的临床疗效研究[J].浙江中医药大学学报,2019,43(1):57-60.DOI: 10.16466/j.issn1005-5509.2019.01.012. [42] WalleT,HsiehF,DeLeggeMH,et al.High absorption but very low bioavailability of oral resveratrol in humans[J].Drug Metab Dispos,2004,32(12):1377-1382.DOI: 10.1124/dmd.104.000885. [43] LarrosaM,Azorín-OrtuñoM,Yañez-GascónMJ,et al.Lack of effect of oral administration of resveratrol in LPS-induced systemic inflammation[J].Eur J Nutr,2011,50(8):673-680.DOI: 10.1007/s00394-011-0178-3. [44] KimMJ,JungSH,MoonI,et al.Syntheses of resveratrol analogues and evaluation of their antioxidant activity[J].Bull Korean Chem Soc,2014,35(5):1549-1552.DOI: 10.5012/BKCS.2014.35.5.1549. [45] 刘亚坤,李刚,颜娟,等.紫檀芪对糖尿病性皮肤溃疡模型大鼠创面愈合的影响及机制[J].中国药房,2023,34(16):1967-1971.DOI: 10.6039/j.issn.1001-0408.2023.16.09.
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