外泌体携带的非编码RNA作为竞争性内源性RNA参与创面修复的研究进展

杨灵璟; 吕叶辉; 林涧

doi:10.3760/cma.j.cn501225-20230811-00044

外泌体携带的非编码RNA作为竞争性内源性RNA参与创面修复的研究进展

doi: 10.3760/cma.j.cn501225-20230811-00044

1.
上海健康医学院创面防治研究所，上海　　201318
2.
上海健康医学院基础医学院，上海　　201318
3.
上海健康医学院附属崇明医院骨科修复重建中心，上海　　202150

基金项目:

国家自然科学基金青年科学基金项目 82301577

上海市青年科技英才扬帆计划 21YF1418800

详细信息

通讯作者:
吕叶辉，Email：lvyh_15@sumhs.edu.cn

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- 被引次数: 0
出版历程
- 收稿日期: 2023-08-11
- 网络出版日期: 2024-06-21

Research advances on the non-coding RNAs carried by exosomes as competitive endogenous RNAs involved in wound healing

1.
Institute of Wound Prevention and Treatment, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China
2.
School of Fundamental Medicine, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China
3.
Department of Center for Orthopedic Repair and Reconstruction, Chongming Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai 202150, China

Funds:

Youth Science Fund Program of National Natural Science Foundation of China 82301577

Shanghai Sailing Program 21YF1418800

More Information

Corresponding author: Lyu Yehui, Email: lvyh_15@sumhs.edu.cn

摘要

摘要: 近年来，外泌体携带的非编码RNA（ncRNA）已被证明在创面修复的多个阶段中起重要的调控作用。外泌体可以将ncRNA运输到不同的靶细胞或组织中，并调节靶基因以及下游分子的表达。而竞争性内源性RNA（ceRNA）假说的提出则提示RNA可通过竞争共同的应答元件搭建更为精细和复杂的基因调控网。因此，该综述聚焦外泌体携带的长链ncRNA和环状RNA，并讨论它们分别作为ceRNA在创面修复的炎症、细胞增殖与组织重塑等阶段中所起的调控作用，同时归纳了外泌体携带的ncRNA作为无细胞疗法的可行性，以期为创面的临床治疗提供理论基础。
- 伤口愈合 /
- 皮肤 /
- 外泌体 /
- RNA，长链非编码 /
- 环状RNA /
- 竞争性内源性RNA调控网络
Abstract: In recent years, non-coding RNAs (ncRNAs) carried by exosomes have been shown to play an important regulatory role in multiple stages of wound healing. Exosomes can transport ncRNAs to different target cells or tissue and regulate the expression of target genes and downstream molecules. The proposed competing endogenous RNA (ceRNA) hypothesis suggests that RNAs can build a more sophisticated and complex gene regulatory network by competing for common response elements. Therefore, this review focuses on the long ncRNAs and circular RNAs carried by exosomes, discusses their regulatory roles as ceRNAs in the stages of inflammation, cell proliferation, and tissue remodeling in wound repair, respectively, and summarizes the feasibility of ncRNAs carried by exosomes as cell-free therapy, in order to provide a theoretical basis for clinical treatment of wounds.
- Wound healing /
- Skin /
- Exosomes /
- RNA,long noncoding /
- Circular RNA /
- Competing endogenous RNA regulatory network
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参考文献(36)

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1 外泌体携带的非编码RNA在创面修复中的作用机制

注：VEGF为血管内皮生长因子，FGF为成纤维细胞生长因子，KLF2为Krüppel样因子2，circRNA为环状RNA，lncRNA为长链非编码RNA，miRNA为微小RNA，SOX9为性别决定区Y框蛋白9，Fb为成纤维细胞，KC为角质形成细胞，PTEN为人第10号染色体缺失的磷酸酶及张力蛋白同源物，ECM为细胞外基质；图中黑色箭头表示促进，蓝色箭头表示分泌，绿色箭头表示结合，红色箭头表示抑制，黄色箭头表示极化

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