延迟腓肠神经营养血管皮瓣在糖尿病足溃疡中的应用与研究进展

龙露瑶; 陈燕微; 邓如非; 姜臻宇; 张友来

doi:10.3760/cma.j.cn501225-20231102-00173

延迟腓肠神经营养血管皮瓣在糖尿病足溃疡中的应用与研究进展

doi: 10.3760/cma.j.cn501225-20231102-00173

南昌大学第一附属医院烧伤整形与创面修复医学中心，南昌　　330006

基金项目:

江西省自然科学基金 2020BABL206072

详细信息

通讯作者:
张友来，Email：1504133139@qq.com

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出版历程
- 收稿日期: 2023-11-02

Application and research advances of delayed sural neurotrophic vascular flap for diabetic foot ulcers

Burn Plastic Surgery and Wound Repair Medical Center, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

Funds:

Natural Science Foundation of Jiangxi Province of China 2020BABL206072

More Information

Corresponding author: Zhang Youlai, Email: 1504133139@qq.com

摘要

摘要: 糖尿病足溃疡是糖尿病的严重并发症之一，创面修复难度大，截肢率高，给患者及其家属与社会均带来较重负担。研究表明，采用延迟腓肠神经营养血管皮瓣修复糖尿病足溃疡可获得较好效果。该文主要从延迟腓肠神经营养血管皮瓣修复糖尿病足溃疡的临床现状与相关研究进展进行综述，拟为该皮瓣的应用与研究提供参考。
- 糖尿病足 /
- 外科皮瓣 /
- 糖尿病血管病变 /
- 腓肠神经营养血管皮瓣 /
- 延迟皮瓣
Abstract: Diabetic foot ulcer is one of the serious complications of diabetes. Diabetic wounds are of great difficulty to repair, causing a high amputation rate and a great burden to patients and their family members and society. Researches showed that the delayed sural neurotrophic vascular flap has a great effect in repairing diabetic foot ulcers. This article mainly reviewed the clinical status and research advances of the delayed sural neurotrophic vascular flap in repairing diabetic foot ulcers, intending to provide a reference for its application and research.
- Diabetic foot /
- Surgical flaps /
- Diabetic angiopathies /
- Sural neurotrophic vascular flap /
- Delayed flap
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参考文献(55)

[1]	ArmstrongDG, BoultonA, BusSA. Diabetic foot ulcers and their recurrence[J]. N Engl J Med, 2017,376(24):2367-2375. DOI: 10.1056/NEJMra1615439.
[2]	EverettE, MathioudakisN. Update on management of diabetic foot ulcers[J]. Ann N Y Acad Sci, 2018,1411(1):153-165. DOI: 10.1111/nyas.13569.
[3]	McDermottK, FangM, BoultonA, et al. Etiology, epidemiology, and disparities in the burden of diabetic foot ulcers[J]. Diabetes Care, 2023,46(1):209-221. DOI: 10.2337/dci22-0043.
[4]	DengH, LiB, ShenQ, et al. Mechanisms of diabetic foot ulceration: a review[J]. J Diabetes, 2023,15(4):299-312. DOI: 10.1111/1753-0407.13372.
[5]	RehmanZU, KhanJ, NoordinS. Diabetic foot ulcers: contemporary assessment and management[J]. J Pak Med Assoc, 2023,73(7):1480-1487. DOI: 10.47391/JPMA.6634.
[6]	ArmstrongDG, TanTW, BoultonA, et al. Diabetic foot ulcers: a review[J]. JAMA, 2023,330(1):62-75. DOI: 10.1001/jama.2023.10578.
[7]	张诗丽, 李姝贤, 黄佳利, 等. 糖尿病皮肤功能障碍及其机制的研究进展[J].中华糖尿病杂志,2023,15(2):195-198. DOI: 10.3760/cma.j.cn115791-20220503-00190.
[8]	谭海涛,林源,蒙诗景,等.腓肠神经营养血管皮瓣的临床应用[J].中华显微外科杂志, 2002, 25(2):147-148.DOI: 10.3760/cma.j.issn.1001-2036.2002.02.031.
[9]	DaiJ, ZhouY, MeiS, et al. Application of the distally based sural neurocutaneous flaps in the management of foot and ankle defects in patients with diabetic foot[J]. Front Endocrinol (Lausanne), 2022,13:1009714. DOI: 10.3389/fendo.2022.1009714.
[10]	朱信霖, 廖万清, 张超, 等. 糖尿病足溃疡发病机制及治疗[J].中国皮肤性病学杂志,2023,37(4):367-372. DOI: 10.13735/j.cjdv.1001-7089.202208134.
[11]	ZouJ, ZhangW, ChenX, et al. Data mining reveal the association between diabetic foot ulcer and peripheral artery disease[J]. Front Public Health, 2022,10:963426. DOI: 10.3389/fpubh.2022.963426.
[12]	张凯糖尿病足下肢动脉病变的临床特点分析石家庄河北医科大学 2013 张凯. 糖尿病足下肢动脉病变的临床特点分析[D].石家庄:河北医科大学,2013.
[13]	BandykDF. The diabetic foot: pathophysiology, evaluation, and treatment[J]. Semin Vasc Surg, 2018,31(2/4):43-48. DOI: 10.1053/j.semvascsurg.2019.02.001.
[14]	魏在荣, 简扬. 糖尿病足创面外科治疗模式探讨[J].中华烧伤与创面修复杂志,2023,39(4):305-310. DOI: 10.3760/cma.j.cn501225-20230213-00044.
[15]	WalshJW, HoffstadOJ, SullivanMO, et al. Association of diabetic foot ulcer and death in a population-based cohort from the United Kingdom[J]. Diabet Med, 2016,33(11):1493-1498. DOI: 10.1111/dme.13054.
[16]	李秋严重的糖尿病下肢动脉病变与糖尿病足及预后的相关性研究济南山东大学 2009 李秋. 严重的糖尿病下肢动脉病变与糖尿病足及预后的相关性研究[D].济南:山东大学,2009.
[17]	李晓强, 胡楠. 糖尿病足下肢缺血血管外科治疗进展与评价[J].中华血管外科杂志,2020,5(4):211-215. DOI: 10.3760/cma.j.cn101411-20201130-00121.
[18]	戴兵, 戴伟. 糖尿病足下肢动脉病变血管外科治疗进展[J].医学研究生学报,2021,34(10):1102-1105. DOI: 10.16571/j.cnki.1008-8199.2021.10.018.
[19]	GalanakisN, MarisTG, KontopodisN, et al. Perfusion imaging techniques in lower extremity peripheral arterial disease[J]. Br J Radiol, 2022,95(1135):20211203. DOI: 10.1259/bjr.20211203.
[20]	林凯桑, 沈洁. 干细胞治疗糖尿病足现状[J].实用医学杂志,2017,33(19):3166-3168. DOI: 10.3969/j.issn.1006-5725.2017.19.003.
[21]	KimK, KimJ, JeongW, et al. Outcome of distal lower leg reconstruction with the propeller perforator flap in diabetic patients[J]. J Plast Surg Hand Surg, 2021,55(4):242-248. DOI: 10.1080/2000656X.2020.1858843.
[22]	YammineK, EricM, NasserJ, et al. Effectiveness of the reverse rural flap in covering diabetic foot ulcers: a systematic review and meta-analysis[J]. Plast Surg (Oakv), 2022,30(4):368-377. DOI: 10.1177/22925503211019617.
[23]	高磊, 石宇, 李天博, 等. 带腓动脉穿支的腓肠神经营养皮瓣在糖尿病足创面修复中的应用[J].中国美容整形外科杂志,2022,33(3):139-142. DOI: 10.3969/j.issn.1673-7040.2022.03.004.
[24]	AssiC, FawazW, SamahaC, et al. Sural neuro-cutaneous flap in the management of foot and ankle soft tissue defects in a diabetic population[J]. J Med Liban, 2016, 64(3): 164-167. DOI: 10.12816/0031526.
[25]	IgnatiadisIA, TsiampaVA, GalanakosSP, et al. The reverse sural fasciocutaneous flap for the treatment of traumatic, infectious or diabetic foot and ankle wounds: a retrospective review of 16 patients[J]. Diabet Foot Ankle, 2011, 2:5653. DOI: 10.3402/dfa.v2i0.5653.
[26]	王培吉,周忠良. 逆行岛状皮瓣或远端蒂皮瓣坏死的原因探讨及防治措施[J]. 中华显微外科杂志,2010,33(2):118-121. DOI: 10.3760/cma.j.issn.1001-2036.2010.02.012.
[27]	KneserU, BachAD, PolykandriotisE,et al. Delayed reverse sural flap for staged reconstruction of the foot and lower leg[J]. Plast Reconstr Surg,2005,116(7):1910-1917.DOI: 10.1097/01.prs.0000189204.71906.c2.
[28]	TosunZ, OzkanA, KaraçorZ,et al. Delaying the reverse sural flap provides predictable results for complicated wounds in diabetic foot[J]. Ann Plast Surg,2005,55(2):169-173.DOI: 10.1097/01.sap.0000170530.51470.1a.
[29]	KarehAM, FelderJM. Successful use of delayed reverse sural artery flap in single vessel legs with severe atherosclerotic disease and venous insufficiency[J]. Plast Reconstr Surg Glob Open, 2023, 11(1): e4740. DOI: 10.1097/GOX.0000000000004740.
[30]	张功林, 师富贵, 王行高, 等. 腓肠神经延迟皮瓣修复足部软组织缺损的临床效果[J/CD].中华临床医师杂志(电子版),2021,15(1):22-25. DOI: 10.3877/cma.j.issn.1674-0785.2021.01.004.
[31]	YousafMA, AbidinZU, KhalidK, et al. Extended islanded reverse sdural artery flap for staged reconstruction of foot defects proximal to toes[J]. J Coll Physicians Surg Pak, 2018,28(2):126-128. DOI: 10.29271/jcpsp.2018.02.126.
[32]	尹克军, 朱兴仁, 龚铁军, 等. 延期转移的低旋转点腓肠神经营养血管皮瓣的临床应用[J].中国骨与关节损伤杂志,2011,26(12):1127-1128.
[33]	林燕娴, 宋维铭. 扩张皮瓣血运障碍监测技术及防治研究进展[J].中国修复重建外科杂志,2018,32(1):118-124. DOI: 10.7507/1002-1892.201708056.
[34]	MaoY, LiH, DingM, et al. Comparative study of choke vessel reconstruction with single and multiple perforator-based flaps on the murine back using delayed surgery[J]. Ann Plast Surg, 2019,82(1):93-98. DOI: 10.1097/SAP.0000000000001637.
[35]	庄跃宏, 梁成, 温福利, 等. 延迟术通过加强血管扩张的方式促进跨区皮瓣存活[J].中国临床解剖学杂志,2015(1):44-50. DOI: 10.13418/j.issn.1001-165x.2015.01.012.
[36]	陈绍锋, 荆幸, 方芳, 等. 时间与缺血程度对皮瓣延迟效果的影响探讨[J].中国临床解剖学杂志,2022,40(4):447-453. DOI: 10.13418/j.issn.1001-165x.2022.4.14.
[37]	ParkS, TepperOM, GalianoRD, et al. Selective recruitment of endothelial progenitor cells to ischemic tissues with increased neovascularization[J]. Plast Reconstr Surg, 2004,113(1):284-293. DOI: 10.1097/01.PRS.0000091169.51035.A5.
[38]	ParrettBM, PribazJJ, MatrosE, et al. Risk analysis for the reverse sural fasciocutaneous flap in distal leg reconstruction[J]. Plast Reconstr Surg, 2009,123(5):1499-1504. DOI: 10.1097/PRS.0b013e3181a07723.
[39]	ErdmannD, GottliebN, HumphreyJS, et al. Sural flap delay procedure: a preliminary report[J]. Ann Plast Surg, 2005,54(5):562-565. DOI: 10.1097/01.sap.0000154873.08087.d5.
[40]	HolzbachT, NeshkovaI, VlaskouD, et al. Searching for the right timing of surgical delay: angiogenesis, vascular endothelial growth factor and perfusion changes in a skin-flap model[J]. J Plast Reconstr Aesthet Surg, 2009,62(11):1534-1542. DOI: 10.1016/j.bjps.2008.05.036.
[41]	LiX, ChenM, JiangZ, et al. Visualized identification of the maximal surgical delay effect in a rat flap model[J]. Wound Repair Regen, 2019,27(1):39-48. DOI: 10.1111/wrr.12680.
[42]	SuzukiA, FujiwaraM, MizukamiT, et al. Delayed distally-based super sural flap: evaluation by indocyanine green fluorescence angiography[J]. J Plast Reconstr Aesthet Surg, 2008,61(4):467-469. DOI: 10.1016/j.bjps.2007.08.019.
[43]	InceB, DaaciM, AltuntasZ, et al. Versatility of delayed reverse-flow islanded sural flap for reconstructing pretibal defects among high-risk patients[J]. Ann Saudi Med, 2014,34(3):235-240. DOI: 10.5144/0256-4947.2014.235.
[44]	胡益高, 李高峰. 高压氧能减轻大鼠延迟皮瓣基底部瘢痕粘连和缩短延迟皮瓣血运重建时间[J].中国组织工程研究,2021,25(11):1658-1663.
[45]	ÜlkürE, KaragozH, ErgunO, et al. The effect of hyperbaric oxygen therapy on the delay procedure[J]. Plast Reconstr Surg, 2007,119(1):86-94. DOI: 10.1097/01.prs.0000244829.68008.21.
[46]	Meethale ThiruvothF, RajasulochanaSR, S MK, et al. Hyperbaric oxygen therapy as an adjunct to the standard wound care for the treatment of diabetic foot ulcers in Indian patients: a cost utility analysis[J]. Expert Rev Pharmacoecon Outcomes Res, 2022,22(7):1087-1094. DOI: 10.1080/14737167.2022.2085562.
[47]	KlebanS, BaynosaRC. The effect of hyperbaric oxygen on compromised grafts and flaps[J]. Undersea Hyperb Med, 2020,47(4):635-648. DOI: 10.22462/10.12.2020.13.
[48]	FindikciogluF, FindikciogluK, YavuzerR, et al. Effect of preoperative subcutaneous platelet-rich plasma and fibrin glue application on skin flap survival[J]. Aesthetic Plast Surg, 2012,36(5):1246-1253. DOI: 10.1007/s00266-012-9954-6.
[49]	李洋, 郑健生, 王彪, 等. 自体富血小板血浆对游离皮瓣修复兔软组织缺损的影响[J].中华烧伤杂志,2019,35(9):683-689. DOI: 10.3760/cma.j.issn.1009-2587.2019.09.007.
[50]	田新立, 江波, 颜洪. 富血小板血浆对大鼠背部超长随意皮瓣成活的影响[J].中华烧伤杂志,2019,35(1):48-53. DOI: 10.3760/cma.j.issn.1009-2587.2019.01.009.
[51]	LineaweaverWC, LeiMP, MustainW, et al. Vascular endothelium growth factor, surgical delay, and skin flap survival[J]. Ann Surg, 2004,239(6):866-873; discussion 873-875. DOI: 10.1097/01.sla.0000128682.53915.92.
[52]	OuyangY, LiC, DuX, et al. Effect of endothelial growth factor on flap surgical delay[J]. Plast Reconstr Surg, 2019,144(6):1116e-1117e. DOI: 10.1097/PRS.0000000000006219.
[53]	SunY, LiQF, ZhangY, et al. Isoflurane preconditioning increases survival of rat skin random-pattern flaps by induction of HIF-1α expression[J]. Cell Physiol Biochem, 2013,31(4/5):579-591. DOI: 10.1159/000350078.
[54]	JiangZ, LiX, ChenM, et al. Effect of endogenous vascular endothelial growth factor on flap surgical delay in a rat flap model[J]. Plast Reconstr Surg, 2019,143(1):126-135. DOI: 10.1097/PRS.0000000000005145.
[55]	UnoT, IshiiN, KiuchiT, et al. Breast reconstruction using delayed pedicled transverse rectus abdominis muscle flap with supercharging: reports of three cases[J].Gland Surg,2021,10(8):2577-2584.DOI: 10.21037/gs-21-322.