细胞外囊泡调节免疫微环境促进糖尿病创面愈合的研究进展

周子悦; 徐广超; 王达利

doi:10.3760/cma.j.cn501225-20231215-00243

细胞外囊泡调节免疫微环境促进糖尿病创面愈合的研究进展

doi: 10.3760/cma.j.cn501225-20231215-00243

遵义医科大学附属医院烧伤整形外科,遵义　　563003

基金项目:

国家自然科学基金面上项目 82072195, 82472567

省部共建协同创新中心项目 2020-39

详细信息

通讯作者:
王达利,Email：daliwangzy@sina.com

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- 被引次数: 0
出版历程
- 收稿日期: 2023-12-15

Research advances on extracellular vesicles in promoting diabetic wound healing through the regulation of immune microenvironment

Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi563003, China

Funds:

General Program of National Natural Science Foundation of China 82072195, 82472567

Collaborative Innovation Center of Chinese Ministry of Education and Guizhou Province 2020-39

More Information

Corresponding author: Wang Dali, Email: daliwangzy@sina.com

摘要

摘要: 糖尿病患者长期高血糖引发的周围神经病变和血液循环不良,常常导致足部创面、溃疡、坏疽,并伴随着创面免疫微环境失调。细胞外囊泡（EV）治疗是一种新兴生物治疗手段,EV具有良好的生物相容性、高效能、低免疫原性和低组织毒性等优点,通过调节微环境中的免疫反应和细胞功能,可以降低创面的炎症水平,在糖尿病创面治疗中显示出巨大潜力。该文综述了EV通过对糖尿病创面的微环境中的多种炎症细胞和非炎症细胞的调控参与调节创面愈合的机制,并讨论了EV临床转化的多种手段的优势与不足,提出EV治疗与疾病微环境相结合的概念,为进一步推动EV的临床应用的研究提供新思路。
- 胞外囊泡 /
- 糖尿病 /
- 免疫调节 /
- 组织微环境 /
- 创面愈合 /
- 临床转化
Abstract: Peripheral neuropathy and poor blood circulation caused by long-term hyperglycemia in patients with diabetes often leads to foot wounds, ulcers, and gangrene, which accompanied by an imbalance in the wound immune microenvironment. Extracellular vesicle (EV) therapy is an emerging biologic treatment method. EV possesses advantages such as good biocompatibility, high efficacy, low immunogenicity, and low tissue toxicity. By modulating the immune responses and cellular functions in the microenvironment, EV can reduce inflammation levels in wounds, showing great potential in accelerating diabetic wound healing. This review summarizes the mechanism by which EV participates in regulating wound healing through the modulation of various inflammatory and non-inflammatory cells in the microenvironment of diabetic wounds, discusses the advantages and limitations of various approaches of the clinical translation of EV, proposes the concept of combining EV therapy with the disease microenvironment, thereby providing new insights for further researches on the clinical application of EV.
- Extracellular vesicles /
- Diabetes mellitus /
- Immunomodulation /
- Tissue microenvironment /
- Wound healing /
- Clinical translation
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