Abstract: Till now, though great progress has been made in the treatment of refractory wound, severe challenges are still awaiting to be solved. The strategy of treatment is generally either non-surgical treatment or surgical treatment. Non-surgical treatment includes physical therapy, negative pressure wound therapy, growth factor therapy, stem cell transplantation, gene therapy, application of new biological dressing, application of skin tissue engineering, three-dimensional bio-printing technology, biological therapy, and Chinese herbal medicine therapy. Surgical treatment mainly includes skin graft transplantation and a variety of skin flap transplantation. To my mind, comprehensive therapy with concept of precision treatment strategy should be advocated for treatment of refractory wound.