Abstract: Since the mechanisms of scar formation are not fully understood, at least to date, there is no ideal method to prevent and treat scar after burn. In recent years, on the basis of conventional treatments, such as pressure therapy, external use of silicone gel, and intralesional injections of corticosteroids, the therapeutic approaches of fractional carbon dioxide laser treatment, injection of anti-vascular endothelial growth factor antibody, autologous fat transplantation, injection of botulinum toxin A, radiation therapy etc., have been gradually applied to treat burn scars. It is very important to select various methods individually and comprehensively according to the specific conditions of patients and scars. Meanwhile, it is necessary to continue to study and explore the possibility of targeted therapy in scar management.