Abstract: Pulse contour cardiac output (PiCCO) monitor as an invasive monitoring technology has been widely applied to various kinds of critical patients. It can reliably reflect actual hemodynamics of critical patients and monitor parameters such as cardiac output. Fluid resuscitation is of great importance for patients with large area of burns. On account of its easy operation as well as precise and comprehensive parameters, PiCCO has been widely used in circulation monitoring of patients with large area of burns. This article briefly introduces PiCCO monitor technology and reviews its application in fluid resuscitation monitoring, diagnosis and identification of pneumonedema in patients with large area of burns, as well as the new theory and knowledge.