Abstract: Pressure ulcer is localized damage to the skin and subcutaneous tissue usually over a bony prominence as a result of prolonged pressure, shear force, and friction. The effect of external force on soft tissue is affected by many factors, such as local microenvironment, tissue blood supply, nutritional status, and underlying diseases of patients. Although great efforts have been made by mankind to prevent and treat pressure ulcer in last decades, its prevalence is still high, and the curative effect is still not impressive. The treatment of pressure ulcer is a challenge today, and it is necessary to seek new treatment methods. However, the prerequisite for exploring new treatment methods is to find a proper animal model and further explore new therapies through animal experiments. The pathogenesis of pressure ulcer is complex, and the formation process is affected by a variety of factors. To date, there is no recognized standard animal model. We review the pathogenesis of pressure ulcer and the recently reported animal models of pressure ulcer, so as to provide basic experimental basis for further research on the occurrence, development, and prevention of pressure ulcer.