Advances in the research of persistent inflammation-immunosuppression-catabolism syndrome in severe burn
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摘要: 持续炎症-免疫抑制-分解代谢综合征(PICS)是经历严重创伤或脓毒症后患者的一种临床综合征,其特征是住重症监护病房时间长、持续的炎症反应、免疫抑制和蛋白质高分解代谢以及高病死率。本文旨在综述PICS概念的提出过程、发生机制、临床特征、诊断和治疗进展,以进一步认识PICS在危重烧伤中的发生机制和病理生理机制,提高危重烧伤患者的临床疗效和预后。Abstract: Persistent inflammation-immunosuppression-catabolism syndrome (PICS) is a clinical syndrome in patients surviving from severe trauma or sepsis, which is characterized by prolonged stays in intensive care unit, persistent inflammation response, immune suppression, high protein catabolism, and high mortality. This article aims to review the proposed process of the concept, the mechanism, the clinical features, and the diagnosis and treatment progress of PICS, which is helpful for further understanding pathogenesis and pathophysiological mechanism of PICS in patients with severe burns and improving clinical curative efficacy and prognosis of patients with severe burns.
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Key words:
- Burns /
- Inflammation /
- Immunosuppression /
- Catabolism syndrome
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