Abstract: Due to difficult healing, wounds become chronic diseases in many patients, and bring heavy burden to family and society in China. Although there are many studies about wound repair at present, its mechanism remains unclear. An increasing number of studies showed that mesenchymal stem cells (MSCs), exosomes, and platelet-rich plasma (PRP) play different important roles in the regulation of different phases of wound repair. This review focuses on the function and mechanism of MSCs, exosomes, and PRP in wound repair.