危重烧伤相关性肾上腺皮质功能不全研究进展

基金项目:

全军后勤科研计划重大专项（AWS14C001）

Advances in the research of severe burn-related corticosteroid insufficiency

1. Burn Institute of PLA, Department of Burn Surgery, the First Affiliated Hospital, Naval Medical University, Shanghai 200433, China;
2. Department of Burns and Plastic Surgery, Zhangjiagang First People′s Hospital (Zhangjiagang Hospital Affiliated to Soochow University), Zhangjiagang 215600, China

摘要:
尽管危重症相关性肾上腺皮质功能不全(CIRCI)在诊疗方面已取得较大进步，但肾上腺皮质功能不全在危重烧伤患者中是否普遍存在，其临床诊治和研究进展如何尚不清楚。危重烧伤是一个累及全身多器官损害的全身性疾病，病程较长，往往存在持续炎症反应、免疫抑制和分解代谢。本文在CIRCI研究基础上，对危重烧伤相关性肾上腺皮质功能不全(SBRCI)的流行病学证据、可能作用机制、可疑临床表现、诊断、治疗等进行简单综述，以期对SBRCI的临床诊治有所帮助。
Abstract:
Despite considerable advances in diagnosis and treatment of the critical illness-related corticosteroid insufficiency (CIRCI), it is still not clear that whether it is common in severe burn patients or not, and how clinical diagnosis, treatment, and research progress. Severe burn is a systemic disease involving the damage of multiple organs of the whole body. The course of the disease is relatively long, and there often exists persistent inflammation, immunosuppression, and catabolism. On the basis of CIRCI study, the epidemiological evidence, possible mechanism, suspicious clinical manifestations, diagnosis and treatment of severe burn-related corticosteroid insufficiency (SBRCI) were briefly reviewed in this article in order to help clinical diagnosis and treatment of SBRCI.