Email Alerts
RSS
Volume 37 Issue 12
Dec.  2021
Turn off MathJax
Article Contents
Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2021  >  37(12): 1199-1204
Li HS,Luo GX,Yuan ZQ.Research advances on the prevention and treatment strategies of burn wound progressive deepening[J].Chin J Burns,2021,37(12):1199-1204.DOI: 10.3760/cma.j.cn501120-20200828-00396.
Citation: Li HS,Luo GX,Yuan ZQ.Research advances on the prevention and treatment strategies of burn wound progressive deepening[J].Chin J Burns,2021,37(12):1199-1204.DOI: 10.3760/cma.j.cn501120-20200828-00396.
shu

Research advances on the prevention and treatment strategies of burn wound progressive deepening

doi: 10.3760/cma.j.cn501120-20200828-00396

  • State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China

Funds:

Military Medical Science and Technology Youth Training Plan 20QNPY011

New Clinical Technology Project of Military Medicine and Trauma Treatment in the First Affiliated Hospital of Army Military Medical University SWH2016YSCXYB-10

More Information
  • Corresponding author: Yuan Zhiqiang, Email: cqburn@aliyun.com
  • Received Date: 2020-08-28
    Abstract
  • The progressive deepening of burn wounds is one of the common clinical problems and difficulties in early burn treatment. At the present, it is believed that local ischemia and hypoxia, persistent inflammation, infection, unbalanced local microenvironment, cell necrosis, apoptosis, and autophagy are the main mechanisms of progressive deepening of burn wounds. In recent years, basic and clinical studies have proposed various new strategies for prevention and treatment of progressive deepening of burn wounds, mainly including correct cooling, improving blood perfusion of the wound, early debridement, improving the wound microenvironment, preventing and treating wound infection, reducing wound inflammation, and inhibiting the oxidative stress in the wound. This review focuses on the current progress of prevention and treatment strategies of burn wound progressive deepening, in order to provide references for the treatment of burn wounds.

     

    • FullText(HTML)
  • loading
    • References(52)
  • [1]
    GrunwaldTB, GarnerWL. Acute burns[J]. Plast Reconstr Surg, 2008, 121(5):311e-319e. DOI: 10.1097/PRS.0b013e318172ae1f.
    [2]
    JacksonDM. The diagnosis of the depth of burning[J]. Br J Surg, 1953, 40(164): 588-596. DOI: 10.1002/bjs.18004016413.
    [3]
    SinghV, DevganL, BhatS, et al. The pathogenesis of burn wound conversion[J]. Ann Plast Surg, 2007, 59(1):109-115. DOI: 10.1097/01.sap.0000252065.90759.e6.
    [4]
    SalibianAA, RosarioATD, SeveroLAM, et al. Current concepts on burn wound conversion-a review of recent advances in understanding the secondary progressions of burns[J]. Burns, 2016,42(5):1025-1035. DOI: 10.1016/j.burns.2015.11.007.
    [5]
    杨宗城. 烧伤治疗学[M]. 3版. 北京: 人民卫生出版社, 2006.
    [6]
    HerndonDN. Total burn care[M].4th ed.London:W.B. Saunders Company,2012.
    [7]
    CuttleL, KempfM, KravchukO, et al. The optimal temperature of first aid treatment for partial thickness burn injuries[J]. Wound Repair Regen,2008,16(5):626-634. DOI: 10.1111/j.1524-475X.2008.00413.x.
    [8]
    HarishV, TiwariN, FisherOM, et al. First aid improves clinical outcomes in burn injuries: evidence from a cohort study of 4918 patients[J]. Burns,2019,45(2):433-439. DOI: 10.1016/j.burns.2018.09.024.
    [9]
    CuttleL, PearnJ, McMillanJR, et al. A review of first aid treatments for burn injuries[J]. Burns,2009,35(6):768-775. DOI: 10.1016/j.burns.2008.10.011.
    [10]
    LawrenceJC. First-aid measures for the treatment of burns and scalds[J]. J Wound Care, 1996,5(7):319-322. DOI: 10.12968/jowc.1996.5.7.319.
    [11]
    SamuelssonA, SteinvallI, SjöbergF. Microdialysis shows metabolic effects in skin during fluid resuscitation in burn-injured patients[J]. Crit Care, 2006,10(6):R172. DOI: 10.1186/cc5124.
    [12]
    StreetzVN, PatatanianLK. Intravenous enoxaparin in pediatric burn patients: a case series[J]. J Pediatr Pharmacol Ther, 2019,24(5):456-461. DOI: 10.5863/1551-6776-24.5.456.
    [13]
    AgbenorkuP, FugarS, AkpalooJ, et al. Management of severe burn injuries with topical heparin: the first evidence-based study in Ghana[J]. Int J Burns Trauma, 2013,3(1):30-36.
    [14]
    VenkatachalapathyTS. A comparative study of paediatric thermal burns treated with topical heparin and without heparin[J]. Indian J Surg, 2014,76(4):282-287. DOI: 10.1007/s12262-012-0674-6.
    [15]
    ManzoorS, KhanFA, MuhammadS, et al. Comparative study of conventional and topical heparin treatment in second degree burn patients for burn analgesia and wound healing[J]. Burns, 2019,45(2):379-386. DOI: 10.1016/j.burns.2018.05.010.
    [16]
    牟世伟, 李海东, 刘瑞. 肝素钠联合磺胺嘧啶银软膏治疗深Ⅱ度烧伤面的临床疗效[J]. 内蒙古医学院学报,2009, 31(6): 557-559.DOI: 10.3969/j.issn.1004-2113.2009.06.010.
    [17]
    ShiYH, LiLG, ChaiJK, et al. Effect of Poloxamer 188 on deepening of deep second-degree burn wounds in the early stage[J]. Burns, 2012,38(1):95-101. DOI: 10.1016/j.burns.2010.06.002.
    [18]
    TobalemM, HarderY, RezaeianF, et al. Secondary burn progression decreased by erythropoietin[J]. Crit Care Med, 2013,41(4):963-971. DOI: 10.1097/CCM.0b013e318275cee7.
    [19]
    BattalMN, HataY, MatsukaK, et al. Reduction of progressive burn injury by using a new nonselective endothelin-A and endothelin-B receptor antagonist, TAK-044: an experimental study in rats[J]. Plast Reconstr Surg, 1997,99(6):1610-1619.
    [20]
    BattalMN, HataY, MatsukaK, et al. Reduction of progressive burn injury by a stable prostaglandin I2 analogue, beraprost sodium (Procylin): an experimental study in rats[J]. Burns, 1996,22(7):531-538. DOI: 10.1016/0305-4179(96)00024-1.
    [21]
    TagkalakisP, DionyssopoulosA, KarkavelasG, et al. Topical use of Rectogesic® and Emla® to improve cutaneous blood perfusion following thermal injury. A comparative experimental study[J]. Ann Burns Fire Disasters, 2015,28(2):134-141.
    [22]
    LuSL, XiangJ, QingC, et al. Effect of necrotic tissue on progressive injury in deep partial thickness burn wounds[J]. Chin Med J (Engl), 2002,115(3):323-325.
    [23]
    ISBI Practice Guidelines Committee, SubcommitteeSteering, SubcommitteeAdvisory. ISBI practice guidelines for burn care[J]. Burns, 2016,42(5):953-1021. DOI: 10.1016/j.burns.2016.05.013.
    [24]
    HircheC, Kreken AlmelandS, DheansaB, et al. Eschar removal by bromelain based enzymatic debridement (Nexobrid®) in burns: European consensus guidelines update[J]. Burns, 2020,46(4):782-796. DOI: 10.1016/j.burns.2020.03.002.
    [25]
    RoHS, ShinJY, SabbaghMD, et al. Effectiveness of aspiration or deroofing for blister management in patients with burns: a prospective randomized controlled trial[J]. Medicine (Baltimore), 2018,97(17):e0563. DOI: 10.1097/MD.0000000000010563.
    [26]
    刘海鹰,王坤,张玉玲, 等.浅Ⅱ°烧伤创面水疱皮保留不同时间水疱液细菌培养结果分析[J].潍坊医学院学报,2019,41(5):400,封三. DOI: 10.16846/j.issn.1004-3101.2019.05.025.
    [27]
    MadaghieleM, DemitriC, SanninoA, et al. Polymeric hydrogels for burn wound care: advanced skin wound dressings and regenerative templates[J/OL]. Burns Trauma, 2014,2(4):153-161[2020-08-28]. https://pubmed.ncbi.nlm.nih.gov/27602378/. DOI: 10.4103/2321-3868.143616.
    [28]
    MurrayRZ, WestZE, CowinAJ, et al. Development and use of biomaterials as wound healing therapies[J/OL]. Burns Trauma, 2019,7:2[2020-08-28]. https://pubmed.ncbi.nlm.nih.gov/30701184/.DOI: 10.1186/s41038-018-0139-7.
    [29]
    刘江,刘毅.壳聚糖纳米纤维创面敷料的研究进展[J].中华烧伤杂志,2020,36(7):627-630. DOI: 10.3760/cma.j.cn501120-20190628-00286.
    [30]
    中国老年医学学会烧创伤分会,吕国忠.胶原类创面材料临床应用全国专家共识(2018版)[J].中华烧伤杂志,2018,34(11):766-769. DOI: 10.3760/cma.j.issn.1009-2587.2018.11.009.
    [31]
    LonginottiC. The use of hyaluronic acid based dressings to treat burns: a review[J/OL]. Burns Trauma, 2014,2(4):162-168 [2020-08-28]. https://pubmed.ncbi.nlm.nih.gov/27602379/.DOI: 10.4103/2321-3868.142398.
    [32]
    郇京宁.创面敷料的发展趋势[J].中华烧伤杂志,2019,35(1):8-11. DOI: 10.3760/cma.j.issn.1009-2587.2019.01.003.
    [33]
    KamolzLP, AndelH, HaslikW, et al. Use of subatmospheric pressure therapy to prevent burn wound progression in human: first experiences[J]. Burns, 2004,30(3):253-258. DOI: 10.1016/j.burns.2003.12.003.
    [34]
    中华医学会烧伤外科学分会,《中华烧伤杂志》编辑委员会.负压封闭引流技术在烧伤外科应用的全国专家共识(2017版)[J].中华烧伤杂志,2017,33(3):129-135. DOI: 10.3760/cma.j.issn.1009-2587.2017.03.001.
    [35]
    CartottoR. Topical antimicrobial agents for pediatric burns[J/OL]. Burns Trauma, 2017,5:33[2020-08-28]. https://pubmed.ncbi.nlm.nih.gov/29075650/.DOI: 10.1186/s41038-017-0096-6.
    [36]
    NímiaHH, CarvalhoVF, IsaacC, et al. Comparative study of Silver Sulfadiazine with other materials for healing and infection prevention in burns: a systematic review and meta-analysis[J]. Burns, 2019,45(2):282-292. DOI: 10.1016/j.burns.2018.05.014.
    [37]
    NhereraLM, TruemanP, RobertsCD, et al. A systematic review and meta-analysis of clinical outcomes associated with nanocrystalline silver use compared to alternative silver delivery systems in the management of superficial and deep partial thickness burns[J]. Burns, 2017,43(5):939-948. DOI: 10.1016/j.burns.2017.01.004.
    [38]
    罗高兴.如何看待银离子制剂或敷料在创面治疗中的应用[J].中华烧伤杂志,2016,32(7):447-448. DOI: 10.3760/cma.j.issn.1009-2587.2016.07.017.
    [39]
    ChoiYM, CampbellK, LevekC, et al. Antibiotic ointment versus a silver-based dressing for children with extremity burns: a randomized controlled study[J]. J Pediatr Surg, 2019,54(7):1391-1396. DOI: 10.1016/j.jpedsurg.2018.06.011.
    [40]
    KhansaI, SchoenbrunnerAR, KraftCT, et al. Silver in wound care-friend or foe?: a comprehensive review[J]. Plast Reconstr Surg Glob Open, 2019,7(8):e2390. DOI: 10.1097/GOX.0000000000002390.
    [41]
    中国老年医学学会烧创伤分会,张家平.含银敷料在创面治疗中应用的全国专家共识(2018版)[J].中华烧伤杂志,2018,34(11):761-765. DOI: 10.3760/cma.j.issn.1009-2587.2018.11.008.
    [42]
    LiuTF, LiuYQ, LiuML, et al. Synthesis of graphene oxide- quaternary ammonium nanocomposite with synergistic antibacterial activity to promote infected wound healing[J/OL]. Burns Trauma, 2018,6:16[2020-08-28]. https://pubmed.ncbi.nlm.nih.gov/29796394/.DOI: 10.1186/s41038-018-0115-2.
    [43]
    SunLT, FriedrichE, HeusleinJL, et al. Reduction of burn progression with topical delivery of (antitumor necrosis factor-α)-hyaluronic acid conjugates[J]. Wound Repair Regen, 2012,20(4):563-572. DOI: 10.1111/j.1524-475X.2012.00813.x.
    [44]
    ChoiM, RabbH, ArnaoutMA, et al. Preventing the infiltration of leukocytes by monoclonal antibody blocks the development of progressive ischemia in rat burns[J]. Plast Reconstr Surg, 1995,96(5):1177-1187.
    [45]
    El AyadiA, WangCZ, ZhangM, et al. Metal chelation reduces skin epithelial inflammation and rescues epithelial cells from toxicity due to thermal injury in a rat model[J/OL]. Burns Trauma, 2020, 8:tkaa024[2021-08-28]. https://pubmed.ncbi.nlm.nih.gov/33033727/.DOI: 10.1093/burnst/tkaa024.
    [46]
    HamblinMR. Novel pharmacotherapy for burn wounds: what are the advancements[J]. Expert Opin Pharmacother, 2019,20(3):305-321. DOI: 10.1080/14656566.2018.1551880.
    [47]
    BegienemanMPV, KubatB, UlrichMMW, et al. Prolonged C1 inhibitor administration improves local healing of burn wounds and reduces myocardial inflammation in a rat burn wound model[J]. J Burn Care Res, 2012,33(4):544-551. DOI: 10.1097/BCR.0b013e31823bc2fc.
    [48]
    YangBW, ChenY, ShiJL. Reactive oxygen species (ROS)- based nanomedicine[J]. Chem Rev, 2019,119(8):4881-4985. DOI: 10.1021/acs.chemrev.8b00626.
    [49]
    XiaoMJ, LiLG, HuQ, et al. Rapamycin reduces burn wound progression by enhancing autophagy in deep second-degree burn in rats[J]. Wound Repair Regen, 2013,21(6):852-859. DOI: 10.1111/wrr.12090.
    [50]
    TürkaslanT, YogunN, CimşitM,et al. Is HBOT treatment effective in recovering zone of stasis? An experimental immunohistochemical study[J]. Burns, 2010,36(4):539-544. DOI: 10.1016/j.burns.2009.06.210.
    [51]
    SingerDD, SingerAJ, GordonC, et al. The effects of rat mesenchymal stem cells on injury progression in a rat model[J]. Acad Emerg Med, 2013,20(4):398-402. DOI: 10.1111/acem.12116.
    [52]
    KayaO, OrhanE, Sapmaz-MetinM, et al. The effects of epidermal growth factor on early burn-wound progression in rats[J]. Dermatol Ther, 2020, 33(1):e13196. DOI: 10.1111/dth.13196.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索
    Get Citation
    PDF
    XML

    Article Metrics

    Article views (757) PDF downloads(143) Cited by()
    Proportional views
    Related

    Copyright © Chinese Journal of Burns京ICP备07035254号-14

    E-mail：shaoshangzazhi@163.com

    Website：https://zhsszz.xml-journal.net/

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return