2021 Vol. 37, No. 12

Expert Forum
New bioactive materials for promoting wound repair and skin regeneration
Lyu Guozhong, Zhao Peng
2021, 37(12): 1105-1109. doi: 10.3760/cma.j.cn501120-20211029-00373
Abstract:
The modulation of microenvironment is a key technology towards promoting wound repair and skin regeneration. In recent years, a series of new bioactive materials that modulate the microenvironment and cell behaviors have been developed, demonstrating highly efficient capability of inducing wound rep...
Original Articles·Treatment of Special Wounds
Clinical effects of partially de-epithelized local flaps in repairing tubercular chest wall defects
Li Pengcheng, Jia Chiyu, Li Dongjie, Chen Liping, Zheng Mengli, Shen Chuan'an
2021, 37(12): 1110-1115. doi: 10.3760/cma.j.cn501120-20210929-00337
Abstract:
Objective To explore the clinical effects of partially de-epithelized local flaps in repairing tubercular chest wall defects. Methods A retrospective observational study was conducted. From April 2010 to February 2021, twelve patients who met the inclusion criteria were admitted to the Department of...
Clinical effects of flaps with cervical cutaneous branch of transverse cervical artery in repairing neck radiation ulcers
Li Gang, Zhang Zhi, Li Yeyang, Wang Jinlun
2021, 37(12): 1116-1121. doi: 10.3760/cma.j.cn501120-20200807-00371
Abstract:
Objective To explore the clinical effects of flaps with cervical cutaneous branch of transverse cervical artery in repairing neck radiation ulcer. Methods The retrospective observational research was conducted. From January 2016 to December 2019, 8 cases with neck radiation ulcer were admitted to Gu...
Original Articles
Prospective study on the analysis of intestinal microflora changes and prediction on metabolic function in severe burn patients at early stage by 16S ribosomal RNA high-throughput sequencing
Guo Zaiwen, Song Mingming, Zhang Jie, Liu Lu, Yang Yunxi, Shao Yiming, Li Linbin, Sun Bingwei
2021, 37(12): 1122-1129. doi: 10.3760/cma.j.cn501120-20200916-00414
Abstract:
Objective To analyze the changes of intestinal microflora and to predict the metabolic function of intestinal microflora in severe burn patients at early stage by 16S ribosomal RNA (rRNA) high-throughput sequencing. Methods In this prospective observational study, 48 patients with severe burns who m...
A prospective randomized controlled study of the effectiveness of artificial dermis combined with split-thickness skin for repairing wounds with bone and tendon exposure in hands and feet
Di Haiping, Mu Xinling, Shi Jijing, Xue Jidong, Liu Lei, Guo Haina, Xing Peipeng, Xia Chengde
2021, 37(12): 1130-1136. doi: 10.3760/cma.j.cn501120-20210325-00103
Abstract:
Objective To explore the clinical effects of artificial dermis combined with split-thickness skin for repairing wounds with bone and tendon exposure in hands and feet. Methods A prospective randomized controlled study was conducted. From October 2018 to February 2020, 82 patients with bone and tendo...
Effects of regional citrate anticoagulation in continuous veno-venous hemofiltration of severe burn patients
Wang Zhiyong, Feng Shihai, Fan Baoli, Ma Wei, Jia Xiangcheng, Geng Hui
2021, 37(12): 1137-1142. doi: 10.3760/cma.j.cn501120-20200816-00381
Abstract:
Objective To investigate the effects of regional citrate anticoagulation in continuous veno-venous hemofiltration (CVVH) of severe burn patients. Methods A retrospective non-randomized controlled study was conducted. From January 2017 to August 2020, sixty-eight severe burn patients who met the incl...
Clinical effects of transplantation of turbocharged bipedicle deep inferior epigastric perforator flap in breast reconstruction
Song Dajiang, Li Zan, Zhang Yixin, Zhou Bo, Lyu Chunliu, Tang Yuanyuan, Yi Liang, Luo Zhenhua, Wang Zhiyuan, Hua Zhanqiang, Feng Guang
2021, 37(12): 1143-1148. doi: 10.3760/cma.j.cn501120-20200824-00390
Abstract:
Objective To explore the clinical effects of transplantation of turbocharged bipedicle deep inferior epigastric perforator (DIEP) flap in breast reconstruction. Methods A retrospective observational study was used. From December 2008 to December 2016, 24 patients who met the inclusion criteria were ...
Effects and cell signaling mechanism of glutamine on rat cardiomyocytes intervened with serum from burned rat
Lyu Shangjun, Fan Ronghui, Wu Dan, Peng Xi
2021, 37(12): 1149-1157. doi: 10.3760/cma.j.cn501120-20210601-00208
Abstract:
Objective To investigate the effects and cell signaling mechanism of glutamine on rat cardiomyocytes intervened with serum from burned rat (hereinafter referred to as burn serum). Methods The experimental research method was applied. Ten gender equally distributed Wistar rats aged 7-8 months were ta...
Effects of N-trimethyl chitosan-recombinant tissue factor pathway inhibitor complex on avulsion flap with roll compaction in rat
Wu Jinfang, Hong Xudong, Jin Jian, Fei Yanghonghong, Zhang Mengyuan, Si Tingting, Fan Hao, Zhang Xudong
2021, 37(12): 1158-1165. doi: 10.3760/cma.j.cn501120-20200914-00409
Abstract:
Objective To investigate the effect of N-trimethyl chitosan-recombinant tissue factor pathway inhibitor (rTFPI) complex on avulsion flap with roll compaction in rat. Methods The experimental methods were adopted. The N-trimethyl chitosan-rTFPI complex solution was prepared by ion cross-linking metho...
Effects of temperature-sensitive hydroxybutyl chitosan hydrogel on wound healing of full-thickness skin defect in rats
Chen Axin, Chen Youbai, Jiang Yufeng, Han Yan
2021, 37(12): 1166-1174. doi: 10.3760/cma.j.cn501120-20200927-00424
Abstract:
Objective To investigate the effects of temperature-sensitive hydroxybutyl chitosan hydrogel on wound healing of full-thickness skin defect in rats. Methods The experimental research method was used. Fifty-one no matter male or female Sprague-Dawley rats aged 7-10 weeks were selected, and two round ...
The effect and mechanism of exosomes derived from human amniotic epithelial cells on the proliferation and migration of HaCaT in high glucose environment
Wei Pei, Xu Zhaorong, Chen Yimin, Chen Xiaodong, Chen Zhaohong
2021, 37(12): 1175-1184. doi: 10.3760/cma.j.cn501120-20210424-00154
Abstract:
Objective To investigate the effect and mechanism of exosomes derived from human amniotic epithelial cells (hAEC-Exos) on the proliferation and migration of HaCaT in high glucose environment. Methods The experimental research method was adopted. The amniotic membrane tissue was collected from 10 hea...
Weighted gene co-expression network analysis of methylated genes in burn scar tissue
Guo Peng
2021, 37(12): 1185-1190. doi: 10.3760/cma.j.cn501120-20200311-00150
Abstract:
Objective To investigate the methylated genes in burn scar tissue by weighted gene co-expression network analysis (WGCNA), and to discover molecular markers and therapeutic targets of scar formation. Methods An observational research method was used. Datasets were downloaded from the National Center...
Case Report
A case of pseudotumor of lower extremity combined with protracted infectious skin ulcer induced by severe hemophilia A
Chen Lan, Xie Weiguo, Yu Gang
2021, 37(12): 1191-1193. doi: 10.3760/cma.j.cn501120-20200801-00366
Abstract:

On July 11, 2018, a 26 years old male patient with pseudotumor of lower extremity combined with protracted infectious skin ulcer induced by severe hemophilia A was admitted to Tongren Hospital of Wuhan University&Wuhan Third Hospital. After treatment of supplementary of clotting factors, prothrombin...

Lecture
Several problems worthy of attention in non-surgical treatment of scar
Liu Yi
2021, 37(12): 1194-1198. doi: 10.3760/cma.j.cn501120-20210705-00235
Abstract:
Pathologically, scars are divided into physiological scars and pathological scars, and the latter mainly include hyperplastic scars and keloids. Scar treatment includes surgical treatment and non-surgical treatment, with the pathological scars as the major targets in treatment. Until now, there is n...
Reviews
Research advances on the prevention and treatment strategies of burn wound progressive deepening
Li Haisheng, Luo Gaoxing, Yuan Zhiqiang
2021, 37(12): 1199-1204. doi: 10.3760/cma.j.cn501120-20200828-00396
Abstract:
The progressive deepening of burn wounds is one of the common clinical problems and difficulties in early burn treatment. At the present, it is believed that local ischemia and hypoxia, persistent inflammation, infection, unbalanced local microenvironment, cell necrosis, apoptosis, and autophagy are...