| Citation: | Zhang JJ,Wang MY,Zhao J,et al.Research advances on the application of stem cells in sweat gland regeneration[J].Chin J Burns Wounds,2022,38(3):296-300.DOI: 10.3760/cma.j.cn501120-20210123-00033.
|
Sweat gland is one of the important appendage organs of the skin, which plays an important role in thermoregulation and homeostasis maintenance. Sweat glands are damaged and unable to self-repair after burns, resulting in perspiration disorders eventually. However, current clinical strategies cannot restore the function of the damaged sweat glands effectively. Therefore, it is urgent to seek treatments that can promote the regeneration of sweat glands and restore their normal functions. Stem cells have extensive sources, low immunogenicity, high proliferation capacity, and multi-directional differentiation potential, which have become a focus in the field of regenerative medicine. In recent years, a variety of stem cells have been induced to differentiate into sweat gland-like tissue with certain secretory function, which provides treatment direction for sweat gland regeneration after burns in clinic. This article reviews the recent research advances on the application of stem cells in sweat gland regeneration from the perspectives of the manner by which stem cells transform into sweat gland cells in different environments and their influencing factors.
| [1] |
刘煜凡,黄沙,付小兵.皮肤附属器汗腺发育及功能的机制研究[J].生命科学,2020,32(3):219-226.DOI: 10.13376/j.cbls/2020030.
|
| [2] |
ChenR,ZhuZ,JiS,et al.Sweat gland regeneration: current strategies and future opportunities[J].Biomaterials,2020,255:120201.DOI: 10.1016/j.biomaterials.2020.120201.
|
| [3] |
姜笃银,宗宪磊,付小兵,等.深Ⅱ度烧伤创面汗腺干细胞标志物的变化规律[J].中华烧伤杂志,2009,25(4):301-304.DOI: 10.3760/cma.j.issn.1009-2587.2009.04.025.
|
| [4] |
WangX,WangX,LiuJ,et al.Hair follicle and sebaceous gland de novo regeneration with cultured epidermal stem cells and skin-derived precursors[J].Stem Cells Transl Med,2016,5(12):1695-1706.DOI: 10.5966/sctm.2015-0397.
|
| [5] |
LinMJ,LuCP.Glandular stem cells in the skin during development, homeostasis, wound repair and regeneration[J].Exp Dermatol,2021,30(4):598-604.DOI: 10.1111/exd.14319.
|
| [6] |
BrandenburgerM,KruseC.Heterogeneity of sweat gland stem cells[J].Adv Exp Med Biol,2019,1169:55-62.DOI: 10.1007/978-3-030-24108-7_3.
|
| [7] |
MaY,LiM,LiuJ,et al.Location, isolation, and identification of mesenchymal stem cells from adult human sweat glands[J].Stem Cells Int,2018,2018:2090276.DOI: 10.1155/2018/2090276.
|
| [8] |
LiaoT,LehmannJ,SternsteinS,et al.Nestin+ progenitor cells isolated from adult human sweat gland stroma promote reepithelialisation and may stimulate angiogenesis in wounded human skin ex vivo[J].Arch Dermatol Res,2019,311(4):325-330.DOI: 10.1007/s00403-019-01889-x.
|
| [9] |
FuX,LiJ,SunX,et al.Epidermal stem cells are the source of sweat glands in human fetal skin: evidence of synergetic development of stem cells, sweat glands, growth factors, and matrix metalloproteinases[J].Wound Repair Regen,2005,13(1):102-108.DOI: 10.1111/j.1067-1927.2005.130113.x.
|
| [10] |
LiJ,FuX,SunX,et al.The interaction between epidermal growth factor and matrix metalloproteinases induces the development of sweat glands in human fetal skin[J].J Surg Res,2002,106(2):258-263.DOI: 10.1006/jsre.2002.6469.
|
| [11] |
LiH,FuX,OuyangY,et al.Adult bone-marrow-derived mesenchymal stem cells contribute to wound healing of skin appendages[J].Cell Tissue Res,2006,326(3):725-736.DOI: 10.1007/s00441-006-0270-9.
|
| [12] |
李海红,付小兵,欧阳云淑,等.人骨髓间充质干细胞表型转化为汗腺细胞的体外研究[J].中华创伤杂志,2006,22(2):81-86.DOI: 10.3760/j:issn:1001-8050.2006.02.001.
|
| [13] |
陈艳,赵洪良,谭志军,等.人骨髓间充质干细胞向汗腺样细胞诱导分化的研究[J].感染、炎症、修复,2014,15(2):76-78.DOI: 10.3969/j.issn.1672-8521.2014.02.003.
|
| [14] |
XuY,HongY,XuM,et al.Role of keratinocyte growth factor in the differentiation of sweat gland-like cells from human umbilical cord-derived mesenchymal stem cells[J].Stem Cells Transl Med,2016,5(1):106-116.DOI: 10.5966/sctm.2015-0081.
|
| [15] |
TaoR,SunTJ,HanYQ,et al.Epimorphin-induced differentiation of human umbilical cord mesenchymal stem cells into sweat gland cells[J].Eur Rev Med Pharmacol Sci,2014,18(9):1404-1410.
|
| [16] |
HuT,XuY,YaoB,et al.Developing a novel and convenient model for investigating sweat gland morphogenesis from epidermal stem cells[J].Stem Cells Int,2019,2019:4254759.DOI: 10.1155/2019/4254759.
|
| [17] |
LiangH,SunQ,ZhenY,et al.The differentiation of amniotic fluid stem cells into sweat glandlike cells is enhanced by the presence of Sonic hedgehog in the conditioned medium[J].Exp Dermatol,2016,25(9):714-720.DOI: 10.1111/exd.13062.
|
| [18] |
WangY,LiuZY,ZhaoQ,et al.Future application of hair follicle stem cells: capable in differentiation into sweat gland cells[J]. Chin Med J(Engl),2013,126(18):3545-3552.DOI: 10.3760/cma.j.issn.0366-6999.20130931.
|
| [19] |
FukutakeM,OchiaiD,MasudaH,et al.Human amniotic fluid stem cells have a unique potential to accelerate cutaneous wound healing with reduced fibrotic scarring like a fetus[J].Hum Cell,2019,32(1):51-63.DOI: 10.1007/s13577-018-0222-1.
|
| [20] |
CaiS,PanY,HanB,et al. Transplantation of human bone marrow-derived mesenchymal stem cells transfected with ectodysplasin for regeneration of sweat glands[J].Chin Med J(Engl),2011,124(15):2260-2268.DOI: 10.3760/cma.j.issn.0366-6999.2011.15.004.
|
| [21] |
SunS,XiaoJ,HuoJ,et al.Targeting ectodysplasin promotor by CRISPR/dCas9-effector effectively induces the reprogramming of human bone marrow-derived mesenchymal stem cells into sweat gland-like cells[J].Stem Cell Res Ther,2018,9(1):8.DOI: 10.1186/s13287-017-0758-0.
|
| [22] |
ChenY,LiQ,TanZ,et al.MicroRNA-mediated regulation of BM-MSCs differentiation into sweat gland-like cells: targeting NF-κB[J].J Mol Histol,2019,50(2):155-166.DOI: 10.1007/s10735-019-09814-2.
|
| [23] |
宋志芳,刘德伍,彭燕,等.miRNA-203转染诱导人表皮干细胞向汗腺细胞分化的研究[J].中国修复重建外科杂志,2015,29(3):343-350.DOI: 10.7507/1002-1892.20150073.
|
| [24] |
WangY,WangR,YaoB,et al.TNF-α suppresses sweat gland differentiation of MSCs by reducing FTO-mediated m6 A-demethylation of Nanog mRNA[J].Sci China Life Sci,2020,63(1):80-91.DOI: 10.1007/s11427-019-9826-7.
|
| [25] |
HuS,YuanJ,XuJ,et al.TNF-α and IFN-γ synergistically inhibit the repairing ability of mesenchymal stem cells on mice colitis and colon cancer[J].Am J Transl Res,2019,11(9):6207-6220.
|
| [26] |
赵换军,丁路,付潇潇,等.HDAC4基因甲基化对hMSCs向汗腺样细胞诱导转分化的影响[J].中国应用生理学杂志,2018,34(4):360-363.DOI: 10.12047/j.cjap.5584.2018.082.
|
| [27] |
陈甫寰,宋慧锋,郭希民,等.氧还蛋白过氧化物2在表皮干细胞向汗腺细胞诱导分化过程中对表型改变的影响[J].中华整形外科杂志,2017,33(1):37-42.DOI: 10.3760/cma.j.issn.1009-4598.2017.01.010.
|
| [28] |
YaoB,SongW,LiZ,et al.Irf6 directs glandular lineage differentiation of epidermal progenitors and promotes limited sweat gland regeneration in a mouse burn model[J].Stem Cell Res Ther,2018,9(1):179.DOI: 10.1186/s13287-018-0929-7.
|
| [29] |
刘坤坤,赵亚平,高玮,等.体外构建干细胞汗腺细胞融合体的初步研究[J].河北医药,2019,41(20):3130-3133.DOI: 10.3969/j.issn.1002-7386.2019.20.020.
|
| [30] |
ZhangM,LiH,ChenL,et al.Three-dimensional reconstructed eccrine sweat glands with vascularization and cholinergic and adrenergic innervation[J].J Mol Histol,2018,49(4):339-345.DOI: 10.1007/s10735-018-9773-4.
|
| [31] |
YaoB,WangR,WangY,et al.Biochemical and structural cues of 3D-printed matrix synergistically direct MSC differentiation for functional sweat gland regeneration[J].Sci Adv,2020,6(10):eaaz1094.DOI: 10.1126/sciadv.aaz1094.
|
| [32] |
王睿.生物3D打印的微环境诱导乳腺祖细胞向汗腺细胞分化的研究[D].天津:天津医科大学,2019.DOI:10.27366/d.cnki.gtyku.2019.000990. |
| [33] |
LiuY,LiZ,LiJ,et al.Stiffness-mediated mesenchymal stem cell fate decision in 3D-bioprinted hydrogels[J/OL].Burns Trauma,2020,8:tkaa029[2021-01-23]. https://academic.oup.com/burnstrauma/article/doi/ 10.1093/burnst/tkaa029/5876593.DOI: 10.1093/burnst/tkaa029.
|
| [34] |
LiuY,LiJ,YaoB,et al.The stiffness of hydrogel-based bioink impacts mesenchymal stem cells differentiation toward sweat glands in 3D-bioprinted matrix[J].Mater Sci Eng C Mater Biol Appl,2021,118:111387.DOI: 10.1016/j.msec.2020.111387.
|
| [35] |
陈润开,付小兵,孙晓艳.体外构建工程化汗腺类器官的初步研究[J].解放军医学杂志,2020,45(4):384-390.DOI: 10.11855/j.issn.0577-7402.2020.04.07.
|
| [36] |
LeiM,SchumacherLJ,LaiYC,et al.Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells[J].Proc Natl Acad Sci U S A,2017,114(34):E7101-E7110.DOI: 10.1073/pnas.1700475114.
|
| [37] |
DiaoJ,LiuJ,WangS,et al.Sweat gland organoids contribute to cutaneous wound healing and sweat gland regeneration[J].Cell Death Dis,2019,10(3):238.DOI: 10.1038/s41419-019-1485-5.
|
Copyright © Chinese Journal of Burns京ICP备07035254号-14
E-mail：shaoshangzazhi@163.com
Supported by:
Beijing Renhe Information Technology Co. Ltd
DownLoad: