Volume 39 Issue 1
Jan.  2023
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Xing N,Huo R,Wang HT,et al.Research advances of adipose stem cell matrix gel in promoting wound healing[J].Chin J Burns Wounds,2023,39(1):81-84.DOI: 10.3760/cma.j.cn501120-20211204-00404.
Citation: Xing N,Huo R,Wang HT,et al.Research advances of adipose stem cell matrix gel in promoting wound healing[J].Chin J Burns Wounds,2023,39(1):81-84.DOI: 10.3760/cma.j.cn501120-20211204-00404.

Research advances of adipose stem cell matrix gel in promoting wound healing

doi: 10.3760/cma.j.cn501120-20211204-00404
Funds:

General Program of National Natural Science Foundation of China 81873938

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  • In recent years, with the problem of aging population in China being prominant, the number of patients with chronic wounds such as diabetic foot, pressure ulcer, and vascular ulcer is increasing. Those diseases seriously affect the life quality of patients and increase the economy and care burden of the patients' family, which have been one of the most urgent clinical problems. Many researches have confirmed that adipose stem cells can effectively promote wound healing, while exogenous protease is needed, and there are ethical and many other problems, which limit the clinical application of adipose stem cells. Adipose stem cell matrix gel is a gel-like mixture of biologically active extracellular matrix and stromal vascular fragment obtained from adipose tissue by the principle of fluid whirlpool and flocculation precipitation. It contains rich adipose stem cells, hematopoietic stem cells, endothelial progenitor cells, and macrophages, etc. The preparation method of adipose stem cell matrix gel is simple and the preparation time is short, which is convenient for clinical application. Many studies at home and abroad showed that adipose stem cell matrix gel can effectively promote wound healing by regulating inflammatory reaction, promoting microvascular reconstruction and collagen synthesis. Therefore, this paper summarized the preparation of adipose stem cell matrix gel, the mechanism and problems of the matrix gel in promoting wound repair, in order to provide new methods and ideas for the treatment of chronic refractory wounds in clinic.

     

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  • [1]
    SoriceS,RustadKC,LiAY,et al.The role of stem cell therapeutics in wound healing: current understanding and future directions[J].Plast Reconstr Surg,2016,138(3 Suppl): S31-41.DOI: 10.1097/PRS.0000000000002646.
    [2]
    RoscaAM,RayiaDM,TutuianuR.Emerging role of stem cells - derived exosomes as valuable tools for cardiovascular therapy[J].Curr Stem Cell Res Ther,2017,12(2):134-138.DOI: 10.2174/1574888X10666151026115320.
    [3]
    JiangM,WangH,JinM,et al.Exosomes from MiR-30d-5p-ADSCs reverse acute ischemic stroke-induced, autophagy-mediated brain injury by promoting M2 microglial/macrophage polarization[J].Cell Physiol Biochem,2018,47(2):864-878.DOI: 10.1159/000490078.
    [4]
    VaseghiH,PornourM,DjavidGE,et al.Association of the gene expression variation of tumor necrosis factor-α and expressions changes of dopamine receptor genes in progression of diabetic severe foot ulcers[J].Iran J Basic Med Sci,2017,20(11):1213-1219.DOI: 10.22038/IJBMS.2017.9475.
    [5]
    YaoY,DongZ,LiaoY,et al.Adipose extracellular matrix/stromal vascular fraction gel: a novel adipose tissue-derived injectable for stem cell therapy[J].Plast Reconstr Surg,2017,139(4):867-879.DOI: 10.1097/PRS.0000000000003214.
    [6]
    RenH,ZhaoF,ZhangQ,et al.Autophagy and skin wound healing[J/OL].Burns Trauma,2022,10:tkac003[2022-02-23]. https://pubmed.ncbi.nlm.nih.gov/35187180/.DOI: 10.1093/burnst/tkac003.
    [7]
    周绍龙,鲁峰,王向义,等.高密度脂肪结合脂肪干细胞胶在女性面部填充的精细化应用[J].中华整形外科杂志,2019,35(7):634-637.DOI: 10.3760/cma.j.issn.1009-4598.2019.07.003.
    [8]
    WangJ,LiaoY,XiaJ,et al.Mechanical micronization of lipoaspirates for the treatment of hypertrophic scars[J].Stem Cell Res Ther,2019,10(1):42.DOI: 10.1186/s13287-019-1140-1.
    [9]
    欧令东,张爱君,李昂,等.人脂肪来源干细胞胶治疗皮肤凹陷性瘢痕患者的作用及其机制[J].中华烧伤杂志,2019,35(12):859-865.DOI: 10.3760/cma.j.issn.1009-2587.2019.12.006.
    [10]
    WangQ,ChenX,WangX,et al.A reliable method for chin augmentation by mechanical micronization of lipoaspirates[J].Aesthetic Plast Surg,2021,45(4):1507-1517.DOI: 10.1007/s00266-021-02237-z.
    [11]
    ZhaoH,HaoL,ChenX,et al.An efficacy study of a new radical treatment for acne vulgaris using fat injection[J].Aesthet Surg J,2021,41(8):NP1061-NP1072.DOI: 10.1093/asj/sjab162.
    [12]
    WangY,ZhuJ,ChenJ,et al.The signaling pathways induced by exosomes in promoting diabetic wound healing: a mini-review[J].Curr Issues Mol Biol,2022,44(10):4960-4976.DOI: 10.3390/cimb44100337.
    [13]
    RenS,ChenJ,GuoJ,et al.Exosomes from adipose stem cells promote diabetic wound healing through the eHSP90/LRP1/AKT Axis[J].Cells,2022,11(20):3229.DOI: 10.3390/cells11203229.
    [14]
    DengC,HeY,FengJ,et al.Conditioned medium from 3D culture system of stromal vascular fraction cells accelerates wound healing in diabetic rats[J].Regen Med,2019,14(10):925-937.DOI: 10.2217/rme-2018-0083.
    [15]
    LiX,XieX,LianW,et al.Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model[J].Exp Mol Med,2018,50(4):1-14.DOI: 10.1038/s12276-018-0058-5.
    [16]
    DengC,WangL,FengJ,et al.Treatment of human chronic wounds with autologous extracellular matrix/stromal vascular fraction gel: a STROBE-compliant study[J].Medicine (Baltimore),2018,97(32):e11667.DOI: 10.1097/MD.0000000000011667.
    [17]
    蒯权,王宜梅,李聪,等.SVF-gel促进糖尿病鼠创面愈合的初步实验研究[J].组织工程与重建外科杂志,2019,15(1):13-16.DOI: 10.3969/j.issn.1673-0364.2019.01.004.
    [18]
    DengC,HeY,FengJ,et al.Extracellular matrix/stromal vascular fraction gel conditioned medium accelerates wound healing in a murine model[J].Wound Repair Regen,2017,25(6):923-932.DOI: 10.1111/wrr.12602.
    [19]
    SunM,HeY,ZhouT,et al.Adipose extracellular matrix/stromal vascular fraction gel secretes angiogenic factors and enhances skin wound healing in a murine model[J].Biomed Res Int,2017,2017:3105780.DOI: 10.1155/2017/3105780.
    [20]
    ZhangP,FengJ,LiaoY,et al.Ischemic flap survival improvement by composition-selective fat grafting with novel adipose tissue derived product - stromal vascular fraction gel[J].Biochem Biophys Res Commun,2018,495(3):2249-2256.DOI: 10.1016/j.bbrc.2017.11.196.
    [21]
    ZhangW,BaiX,ZhaoB,et al.Cell-free therapy based on adipose tissue stem cell-derived exosomes promotes wound healing via the PI3K/Akt signaling pathway[J].Exp Cell Res,2018,370(2):333-342.DOI: 10.1016/j.yexcr.2018.06.035.
    [22]
    YuanX,LiL,LiuH,et al.Strategies for improving adipose-derived stem cells for tissue regeneration[J/OL].Burns Trauma,2022,10:tkac028[2022-11-23]. https://pubmed.ncbi.nlm.nih.gov/35992369/.DOI: 10.1093/burnst/tkac028.
    [23]
    LongC,WangJ,GanW,et al.Therapeutic potential of exosomes from adipose-derived stem cells in chronic wound healing[J].Front Surg,2022,9:1030288.DOI: 10.3389/fsurg.2022.1030288.
    [24]
    HongP,YangH,WuY,et al.The functions and clinical application potential of exosomes derived from adipose mesenchymal stem cells: a comprehensive review[J].Stem Cell Res Ther,2019,10(1):242.DOI: 10.1186/s13287-019-1358-y.
    [25]
    TsiapalisD,O'DriscollL.Mesenchymal stem cell derived extracellular vesicles for tissue engineering and regenerative medicine applications[J].Cells,2020,9(4):991.DOI: 10.3390/cells9040991.
    [26]
    LiuM,ShangY,LiuN,et al.Strategies to improve AFT volume retention after fat grafting[J/OL].Aesthetic Plast Surg,2022[2022-11-23]. https://pubmed.ncbi.nlm.nih.gov/36316460/. DOI:10.1007/s00266-022-03088-y.[published online ahead of print October 31,2022].
    [27]
    LiQ,ZhaoF,LiZ,et al.Autologous fractionated adipose tissue as a natural biomaterial and novel one-step stem cell therapy for repairing articular cartilage defects[J].Front Cell Dev Biol,2020,8:694.DOI: 10.3389/fcell.2020.00694.
    [28]
    YinS,YangX,BiH,et al.Combined use of autologous stromal vascular fraction cells and platelet-rich plasma for chronic ulceration of the diabetic lower limb improves wound healing[J].Int J Low Extrem Wounds,2021,20(2):135-142.DOI: 10.1177/1534734620907978.
    [29]
    ZhuH,GeJ,ChenX,et al.Mechanical micronization of lipoaspirates for regenerative therapy[J].J Vis Exp,2019(145).DOI: 10.3791/58765.
    [30]
    ZhangY,ZouJ,YuanY,et al.Contouring and augmentation of the temple using stromal vascular fraction gel grafting[J].Front Surg,2022,9:893219.DOI: 10.3389/fsurg.2022.893219.
    [31]
    YangZ,JinS,HeY,et al.Comparison of microfat, nanofat, and extracellular matrix/stromal vascular fraction gel for skin rejuvenation: basic research and clinical applications[J].Aesthet Surg J,2021,41(11):NP1557-NP1570.DOI: 10.1093/asj/sjab033.
    [32]
    漆江鸿, 蔡原, 邓呈亮. 脂肪组织及脂肪成分移植在瘢痕治疗中的作用研究进展[J]. 中华烧伤杂志,2020,36(7):623-626. DOI: 10.3760/cma.j.cn501120-20200311-00151.
    [33]
    LuoS,ZhangX,DongH,et al.Correction of the tear trough deformity and concomitant infraorbital hollows with extracellular matrix/stromal vascular fraction gel[J].Dermatol Surg,2020,46(12):e118-e125.DOI: 10.1097/DSS.0000000000002359.
    [34]
    JiangS,QuanY,WangJ,et al.Fat grafting for facial rejuvenation using stromal vascular fraction gel injection[J].Clin Plast Surg,2020,47(1):73-79.DOI: 10.1016/j.cps.2019.09.001.
    [35]
    FengJ,HuW,FanaiML,et al.Mechanical process prior to cryopreservation of lipoaspirates maintains extracellular matrix integrity and cell viability: evaluation of the retention and regenerative potential of cryopreserved fat-derived product after fat grafting[J].Stem Cell Res Ther,2019,10(1):283.DOI: 10.1186/s13287-019-1395-6.
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