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Volume 39 Issue 1
Jan.  2023
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2023  >  39(1): 91-95
Guo J,Zhang JX.Research advances on the role of nuclear factor-erythroid 2-related factor 2 in wound healing[J].Chin J Burns Wounds,2023,39(1):91-95.DOI: 10.3760/cma.j.cn501225-20220531-00209.
Citation: Guo J,Zhang JX.Research advances on the role of nuclear factor-erythroid 2-related factor 2 in wound healing[J].Chin J Burns Wounds,2023,39(1):91-95.DOI: 10.3760/cma.j.cn501225-20220531-00209.
shu

Research advances on the role of nuclear factor-erythroid 2-related factor 2 in wound healing

doi: 10.3760/cma.j.cn501225-20220531-00209

  • School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, China

Funds:

Natural Science Foundation of Hubei Province of China 2020CFB574

Key Supporting Projects of Hubei Provincial Health Research Fund WJ2021Z010

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    Abstract
  • Wound healing is one of the common pathophysiological processes in the body. How to improve the condition of wound healing to promote rapid wound healing has always been a hotspot in research. Oxidative stress is one of the important factors affecting wound healing. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a classic antioxidant stress factor as well as a factor with great potential in facilitating wound healing. The activation of Nrf2 can regulate the downstream antioxidant stress elements and play roles of anti-apoptosis and cell homeostasis maintaining, which improves wound healing environment and promotes wound repair. This paper summarized the common agonists and inhibitors of Nrf2 and reviewed the roles of Nrf2 in promoting skin wound healing including diabetic ulcers, radiation injury, and ischemia-reperfusion injury, etc.

     

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