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Volume 40 Issue 2
Feb.  2024
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2024  >  40(2): 190-195
Jian XC,Deng CL.Research advances on the role of microRNA engineered exosomes in diabetic wounds[J].Chin J Burns Wounds,2024,40(2):190-195.DOI: 10.3760/cma.j.cn501225-20230721-00011.
Citation: Jian XC,Deng CL.Research advances on the role of microRNA engineered exosomes in diabetic wounds[J].Chin J Burns Wounds,2024,40(2):190-195.DOI: 10.3760/cma.j.cn501225-20230721-00011.
shu

Research advances on the role of microRNA engineered exosomes in diabetic wounds

doi: 10.3760/cma.j.cn501225-20230721-00011

  • Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China

Funds:

Science and Technology Plan Project of Guizhou Province of China ZK2021-011, 2021-079, 2020-1Y331

Collaborative Innovation Center of Chinese Ministry of Education 2020-39

More Information
  • Corresponding author: Deng Chengliang, Email: cheliadeng@sina.com
  • Received Date: 2023-07-21
    Available Online: 2024-02-26
    Abstract
  • Diabetic wounds are a common complication in patients with diabetes, which is difficult to treat. Current treatment methods for diabetic wounds include debridement, functional dressing coverage, negative pressure therapy, bone cement filling, and skin grafting, etc. MicroRNA (miRNA) engineered exosomes have shown promising potential in diabetic wound repair due to the ability to alleviate inflammation, stimulate angiogenesis, and promote collagen deposition and re-epithelialization. Related researches are being actively carred out. This paper reviews the pathophysiological characteristics of diabetic wounds, the characteristics of miRNA and exosomes, the engineering methods for exosomes loaded with miRNA, and the mechanism of miRNA engineered exosomes in promoting healing of diabetic wounds, aiming to provide a reference basis for the future clinical application of miRNA engineered exosomes in diabetic wounds.

     

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