2022 Vol. 38, No. 5

Expert Forum
Inspiration from the research advances in microcirculatory dysfunction to the treatment of burn shock and burn septic shock
Huan Jingning, Zhang Lijun
2022, 38(5): 401-407. doi: 10.3760/cma.j.cn501225-20220323-00082
Abstract:
Microcirculatory dysfunction is an important pathophysiological change of shock. In the last decade, many researches on the mechanism of microcirculatory dysfunction have been involved in areas such as the glycocalyx damage of vascular endothelial cells, macrocirculation- microcirculation discouplin...
Original Articles·Burn Complication and Organ Dysfuction
Analysis of the clinical characteristics and risk factors of postoperative atrial fibrillation in patients with critical burns
Chen Bin, Tang Wenbin, Li Xiaojian, Ou Shali, Li Xinying, Xiao Kui, Wang Sisi
2022, 38(5): 408-414. doi: 10.3760/cma.j.cn501225-20220214-00026
Abstract:
Objective To investigate the clinical characteristics and risk factors of postoperative atrial fibrillation (POAF) in patients with critical burns. Methods A retrospective case series study was conducted. From January 2017 to December 2021, two hundred and twenty-seven critically burned aldult patie...
Retrospective analysis of 35 burn patients in different stages of pregnancy
Zhou Jinxiu, Guo Guanghua, Yu Gang, Hong Huili, Xie Weiguo, Liu Shuhua
2022, 38(5): 415-421. doi: 10.3760/cma.j.cn501225-20220214-00027
Abstract:
Objective To summarize the clinical outcomes of burn patients in different stages of pregnancy and explore a rational therapeutic scheme for burns during pregnancy. Methods A retrospective observational study was conducted. From June 2010 to June 2020, 21 patients who met the inclusion criteria were...
Effects of non-muscle myosin silenced bone marrow-derived mesenchymal stem cells transplantation on lung extracellular matrix in rats after endotoxin/lipopolysaccharide-induced acute lung injury
Yin Xi, Zhou Wanfang, Hou Wenjia, Fan Mingzhi, Wu Guosheng, Liu Xiaobin, Ma Qimin, Wang Yusong, Zhu Feng
2022, 38(5): 422-433. doi: 10.3760/cma.j.cn501225-20220212-00024
Abstract:
Objective To investigate the effects of non-muscle myosin Ⅱ (NMⅡ) gene silenced bone marrow-derived mesenchymal stem cells (BMMSCs) on pulmonary extracellular matrix (ECM) and fibrosis in rats with acute lung injury (ALI) induced by endotoxin/lipopolysaccharide (LPS). Methods The experimental resear...
Original Articles
Effects of transient receptor potential vanilloid type 4-specific activator on human vascular endothelial cell functions and blood supply of rat perforator flap and its mechanism
Yimin Khoong, Huang Xin, Meng Xuchang, Gu Shuchen, Zhang Zewei, Liu Yunhan, Luo Shenying, Zan Tao
2022, 38(5): 434-446. doi: 10.3760/cma.j.cn501120-20210419-00138
Abstract:
Objective To analyze the effects of transient receptor potential vanilloid type 4 (TRPV4) activation on the function and endothelial-to-mesenchymal transition (EndMT) of human umbilical vein endothelial cells (HUVECs), as well as to explore the effects of TRPV4 activation on blood perfusion and surv...
A prospective randomized controlled study on the effects of bicycle ergometer rehabilitation training on quadriceps and walking ability of patients with lower limb dysfunction caused by extensive burns
Wu Kunping, Chen Pei, Ru Tianfeng, Yuan Lin, Luo Hao, Xie Weiguo
2022, 38(5): 447-453. doi: 10.3760/cma.j.cn501120-20210221-00060
Abstract:
Objective To explore the effects of bicycle ergometer rehabilitation training on quadriceps and walking ability of patients with lower limb dysfunction caused by extensive burns. Methods A prospective randomized controlled study was conducted. A total of 40 patients with extensive burns who met the ...
Effects of expanded frontal-parietal pedicled flap in reconstructing cervical scar contracture deformity in children after burns
Xia Chengde, Xue Jidong, Xing Peipeng, Guo Haina, Cao Dayong, Xie Jiangfan, Han Dawei, Di Haiping
2022, 38(5): 454-461. doi: 10.3760/cma.j.cn501120-20210507-00172
Abstract:
Objective To explore the effects of expanded frontal-parietal pedicled flap in reconstructing cervical scar contracture deformity in children after burns. Methods A retrospective observational study was conducted. From January 2015 to December 2020, 18 male children with cervical scar contracture de...
Role and mechanism of Vγ4 T cells in impaired wound healing of rapamycin-induced full-thickness skin defects in mice
Liu Zhongyang, Cheng Xu, Zhang Jingxia, Zhang Jianwen, Guo Lili, Li Guangshuai, Shi Ke
2022, 38(5): 462-470. doi: 10.3760/cma.j.cn501120-20201209-00523
Abstract:
Objective To investigate the role and mechanism of Vγ4 T cells in impaired wound healing of rapamycin-induced full-thickness skin defects in mice. Methods The experimental research methods were applied. Eighty-six C57BL/6J male mice (hereinafter briefly referred to as wild-type mice) aged 8-12 weeks...
Regulatory effects and signaling mechanism of sodium ferulate on the proliferation and apoptosis of human skin hypertrophic scar fibroblasts
Wang Chang, Chen Wei, Wang Baojia
2022, 38(5): 471-480. doi: 10.3760/cma.j.cn501120-20201120-00484
Abstract:
Objective To investigate the regulatory effects and signaling mechanism of sodium ferulate on the proliferation and apoptosis of human skin hypertrophic scar fibroblasts (HSFbs). Methods The experimental research methods were used. The 4th-6th passage of HSFbs from human skin were used for the follo...
Reviews
Research advances on the techniques for diagnosing burn wound depth
Liu Yijia, Wu Peng, An Gang, Fang Qiu, Zheng Jia, Wang Yibing
2022, 38(5): 481-485. doi: 10.3760/cma.j.cn501120-20210518-00195
Abstract:
The accurate diagnosis of burn wound depth is particularly important for evaluating the disease prognosis of burn patients. In the past, the diagnosis of burn wound depth often relied on the subjective judgment of doctors. With the continuous development of diagnostic technology, the methods for jud...
Current status and prospect of virtual reality technique′s application in wound repair
Li Hengchang, Li Jiehui, Lu Wei, He Xuan
2022, 38(5): 486-490. doi: 10.3760/cma.j.cn501120-20210805-00270
Abstract:
As a new technology of drug-free treatment, virtual reality technique has been used in various medical fields, and is being increasingly applied in the field of wound repair. Virtual reality technology can alleviate the pain caused by acute and chronic wounds, relieve the psychological anxiety of pa...
Research advances on exosomes derived from adipose-derived mesenchymal stem cells in promoting diabetic wound healing
Wang Yixi, Chen Junjie, Cen Ying, Li Zhengyong, Zhang Zhenyu
2022, 38(5): 491-495. doi: 10.3760/cma.j.cn501120-20210218-00057
Abstract:

Impaired healing of diabetic wounds is mainly attributed to its pathological mechanism, and refractory diabetic wounds bring heavy burdens to patients and society. Exosomes derived from stem cells possess the similar ability as stem cells in promoting tissue regeneration and more clinical advantages...

Research advances of the roles of sphingosine-1-phosphate in acute lung injury
Wang Mengyan, Cui Pei, Xin Haiming
2022, 38(5): 496-500. doi: 10.3760/cma.j.cn501120-20210703-00234
Abstract:
Sphingosine-1-phosphate (S1P) is the main metabolite produced in the process of phospholipid metabolism, which can promote proliferation, migration, and apoptosis of cells, and maintain the barrier function of vascular endothelium. The latest researches showed that S1P can alleviate acute lung injur...