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2024 Vol. 40, No. 6

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Expert Forum
Diagnosis and treatment strategies of chronic radiation ulcers
Shen Yuming, Hu Yungang
2024, 40(6): 501-506. doi: 10.3760/cma.j.cn501225-20240308-00091
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With the increase of radiotherapy and various interventional therapies for tumor, the number of patients with chronic radiation ulcers is increasing gradually. Chronic radiation ulcers mostly involve the deep subcutaneous layers, accompanied by fibrosis of the surrounding skin. The ulcers persist an...
Roles of hypoxia and inflammation in wound healing
Wei Zairong, Zhang Yanji, Wang Dali
2024, 40(6): 507-513. doi: 10.3760/cma.j.cn501225-20240111-00014
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Wound healing is a complex biological process. Hypoxia and inflammation are the two key factors that initiate wound healing and affect the wound healing process. Hypoxia-inducible factor-1α (HIF-1α) and nuclear factor κB are the important regulators of hypoxia and inflammation. The interaction betwe...
Transcriptomic research on severe burns: value and prospects
Jia Chiyu, Yin Bin, Zhang Zexin
2024, 40(6): 514-520. doi: 10.3760/cma.j.cn501225-20231026-00135
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Transcriptomics technology has shown remarkable application effects in multiple disease fields, but its application in severe burns, especially in the field of burn sepsis, is still superficial. The use of transcriptomics and big data methods to solve the long-standing challenges of severe burns, es...
Original Article·Refractory Wound Repair
Repair strategy of chest radiation ulcer after radical mastectomy for breast cancer and its clinical effect
Du Weili, Shen Yuming, Cheng Lin, Dai Qiang, Che Kexin
2024, 40(6): 521-528. doi: 10.3760/cma.j.cn501225-20240315-00099
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Objective To explore the repair strategy of chest radiation ulcer after radical mastectomy for breast cancer and its clinical effect. Methods The study was a retrospective observational study. From September 2020 to September 2023, 27 female patients (aged 37-83 years) with chest radiation ulcers af...
Repair methods and effects of refractory wounds in patients after spinal internal fixation operation
Li Lili, Yu Wenchang, Li Bo, Wu Deyong, Wang Jinyong, Zou Xiaohui, Wang Mingzhu, Xu Xiangrong
2024, 40(6): 529-535. doi: 10.3760/cma.j.cn501225-20240218-00066
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Objective To explore the repair methods and effects of refractory wounds in patients after spinal internal fixation operation . Methods The study was a retrospective observational study. From November 2020 to October 2023, 10 patients with refractory wounds after spinal internal fixation operation ...
Diagnosis and treatment strategy of complex post-sternotomy mediastinitis with exposure of artificial implants
Xie Kun, Zhang Zhengkui, Wen Bing
2024, 40(6): 536-542. doi: 10.3760/cma.j.cn501225-20240227-00074-0515
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Objective To explore the diagnosis and treatment strategy of complex post-sternotomy mediastinitis with exposure of artificial implants (hereinafter referred to as implants). Methods This study was a retrospective observational study. From January 2016 to January 2023, 16 patients with complex media...
Original Article
Relationship between the lowest hemoglobin value during hospitalization and the prognosis in patients with extensive burns
Zuo Fangqing, Su Jiaqing, Li Yang, Zhang Lijuan, Lan Yingying, Chen Yu, Gong Yali, Chen Yajie, Li Junda, Peng Yizhi, Luo Gaoxing, Yuan Zhiqiang
2024, 40(6): 543-550. doi: 10.3760/cma.j.cn501225-20240228-00075
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Objective To investigate the relationship between the lowest hemoglobin value during hospitalization and the prognosis in patients with extensive burns, in order to explore the hemoglobin warning threshold for blood transfusion in patients with extensive burns. Methods The research was a retrospecti...
Clinical effect of unilateral superior gluteal artery perforator propeller flap combined with contralateral centripetal advancement flap in repairing huge pressure ulcers in the sacrococcygeal region
Li Jun, Liu Mengdong, Zhu Liang, Luo Yuming, Yang Qiying, Gao Xiaowen, Han Juntao
2024, 40(6): 551-556. doi: 10.3760/cma.j.cn501225-20231031-00158
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Objective To explore the feasibility and clinical effects of unilateral superior gluteal artery perforator propeller flap combined with contralateral centripetal advancement flap in repairing huge pressure ulcers in the sacrococcygeal region. Methods The study was a retrospective observational study...
Application effects of indwelling nasoenteric tubes under bedside electromagnetic navigation in patients with extremely severe burns
Zhang Lingling, Zhang Wei, Wang Congcong, Zhang Liping
2024, 40(6): 557-563. doi: 10.3760/cma.j.cn501225-20231010-00108
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Objective To investigate the application effects of indwelling nasoenteric tubes under bedside electromagnetic navigation in patients with extremely severe burns. Methods This study was a retrospective cohort study. The 27 patients with extremely severe burns who were admitted to Shandong Provincial...
Clinical effects of anterolateral femoral or anteromedial femoral perforator flaps in repairing skin and soft tissue defects after resection of cutaneous squamous cell carcinoma
Liu Ruobing, Zheng Deyi, Wang Baoyun, Li Weiren
2024, 40(6): 564-571. doi: 10.3760/cma.j.cn501225-20231114-00193
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Objective To explore the clinical effects of anterolateral femoral or anteromedial femoral perforator flaps in repairing skin and soft tissue defects after resection of cutaneous squamous cell carcinoma (CSCC). Methods This study was a retrospective observational study. From July 2015 to July 2022, ...
Analysis of the causal relationship between human immune cells and hypertrophic scar using two-sample bidirectional Mendelian randomization method
Wu Honglin, Chen Yongfei, Li Shuting, Yang Hao, Li Xiaohui, Tang Bing, Zhu Jiayuan, Hu Zhicheng
2024, 40(6): 572-578. doi: 10.3760/cma.j.cn501225-20240203-00046
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Objective To explore the causal relationship between human immune cells and hypertrophic scar (HS) using two-sample bidirectional Mendelian randomization (MR) method. Methods This study was based on two-sample MR method, and the datasets of 731 immune cells and HS were obtained from the genome-wide ...
Effects and mechanism of metformin on the wound healing of full-thickness skin defects in diabetic rats
Wang Baohong, Zhang Yanbing, Zhang Xianping, Li Yuting, Wu Zhihui, Hu Rongying, Zhao Shiyue, Jiang Hongna, Yao Yuwei, Dong Jianda
2024, 40(6): 579-588. doi: 10.3760/cma.j.cn501225-20231219-00253
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Objective To investigate the effects and mechanism of metformin on the wound healing of full-thickness skin defects in diabetic rats. Methods This study was an experimental study. Eighteen 8-week-old male Sprague Dawley rats were divided into control group, diabetes group, and diabetes+metformin gro...
Review
Research advances on the roles of metabolic remodeling and protein acylation modification in keloids
Mu Zelan, Teng Yongxiang, Zhang Jian, Bai Nan, Fu Yanjie
2024, 40(6): 589-593. doi: 10.3760/cma.j.cn501225-20231207-00229
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Keloid is a common skin disease, and the mechanism of its occurrence is not fully understood. There is evidence to show that multiple factors such as genetics, race, age, gender, hormones, infection, immunity, and oxidative stress, etc. may be related to the occurrence of keloids. Metabolic remodeli...
Research advances on the non-coding RNAs carried by exosomes as competitive endogenous RNAs involved in wound healing
Yang Lingjing, Lyu Yehui, Lin Jian
2024, 40(6): 594-599. doi: 10.3760/cma.j.cn501225-20230811-00044
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In recent years, non-coding RNAs (ncRNAs) carried by exosomes have been shown to play an important regulatory role in multiple stages of wound healing. Exosomes can transport ncRNAs to different target cells or tissue and regulate the expression of target genes and downstream molecules. The proposed...
2024, 40(6): 600-600. doi: 10.3760/cma.j.cn501225-20240515-00177
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