Volume 39 Issue 6
Jun.  2023
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Article Contents
Lyu Y,Chu WL,Chen Y,et al.Research advances on conductive hydrogels and their applications in the repair of diabetic wounds[J].Chin J Burns Wounds,2023,39(6):586-590.DOI: 10.3760/cma.j.cn501225-20220929-00425.
Citation: Lyu Y,Chu WL,Chen Y,et al.Research advances on conductive hydrogels and their applications in the repair of diabetic wounds[J].Chin J Burns Wounds,2023,39(6):586-590.DOI: 10.3760/cma.j.cn501225-20220929-00425.

Research advances on conductive hydrogels and their applications in the repair of diabetic wounds

doi: 10.3760/cma.j.cn501225-20220929-00425
Funds:

Beijing Institute of Technology Research Start-up Fund Program for Young Scholars 3320011182201

Beijing Natural Science Foundation-Haidian Original Innovation Joint Fund L222036

Basic Strengthening Program Project 2022-JCJQ-ZD-224-12

More Information
  • As a new type of functional wound dressing, conductive hydrogel, shows broad prospects of application in the field of wound repair due to its suitable electrical conductivity, good moisture retention, excellent biocompatibility, and biological effects such as mediating cell migration and proliferation, and promoting angiogenesis and collagen deposition. Combined with the clinical electrical stimulation therapy, the conductive hydrogel primarily showed curative effects of promoting granulation tissue formation, re-epithelialization, and wound healing, providing a new treatment idea for the repair of diabetic wounds. This review summarized the research advances of electronic conductive hydrogels and ionic conductive hydrogels in recent years based on different conductive mechanisms. Meanwhile, the applications of conductive hydrogel in the diabetic wound repair were specifically introduced, and the future development of conductive hydrogel wound dressing was prospected.

     

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  • [1]
    MartinP.Wound healing--aiming for perfect skin regeneration[J].Science,1997,276(5309):75-81.DOI: 10.1126/science.276.5309.75.
    [2]
    马雯迪 多功能复合水凝胶基伤口敷料的制备与性能研究 长春 吉林大学 2022

    马雯迪.多功能复合水凝胶基伤口敷料的制备与性能研究[D].长春:吉林大学,2022.

    [3]
    NussbaumSR,CarterMJ,FifeCE,et al.An economic evaluation of the impact, cost, and medicare policy implications of chronic nonhealing wounds[J].Value Health,2018,21(1):27-32.DOI: 10.1016/j.jval.2017.07.007.
    [4]
    HosoyamaK,AhumadaM,GoelK,et al.Electroconductive materials as biomimetic platforms for tissue regeneration[J].Biotechnol Adv,2019,37(3):444-458.DOI: 10.1016/j.biotechadv.2019.02.011.
    [5]
    KorupalliC,LiH,NguyenN,et al.Conductive materials for healing wounds: their incorporation in electroactive wound dressings, characterization, and perspectives[J].Adv Healthc Mater,2021,10(6):e2001384.DOI: 10.1002/adhm.202001384.
    [6]
    ZhaoM,SongB,PuJ,et al.Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN[J].Nature,2006,442(7101):457-460.DOI: 10.1038/nature04925.
    [7]
    GaoC,SongS,LvY,et al.Recent development of conductive hydrogels for tissue engineering: review and perspective[J].Macromol Biosci,2022,22(8):e2200051.DOI: 10.1002/mabi.202200051.
    [8]
    ZhaoX,LiP,GuoB,et al.Antibacterial and conductive injectable hydrogels based on quaternized chitosan-graft-polyaniline/oxidized dextran for tissue engineering[J].Acta Biomater,2015,26:236-248.DOI: 10.1016/j.actbio.2015.08.006.
    [9]
    ZhaoX,WuH,GuoB,et al.Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing[J].Biomaterials,2017,122:34-47.DOI: 10.1016/j.biomaterials.2017.01.011.
    [10]
    LiS,WangL,ZhengW,et al.Rapid fabrication of self‐healing, conductive, and injectable gel as dressings for healing wounds in stretchable parts of the body[J]. Adv Funct Mater,2020,30(31):2002370.DOI: 10.1002/adfm.202002370.
    [11]
    GanD,HanL,WangM,et al.Conductive and tough hydrogels based on biopolymer molecular templates for controlling in situ formation of polypyrrole nanorods[J].ACS Appl Mater Interfaces,2018,10(42):36218-36228.DOI: 10.1021/acsami.8b10280.
    [12]
    ZhangB,HeJ,ShiM,et al.Injectable self-healing supramolecular hydrogels with conductivity and photo-thermal antibacterial activity to enhance complete skin regeneration[J].Chem Eng J,2020,400:125994.DOI: 10.1016/j.cej.2020.125994.
    [13]
    LiangY,ZhaoX,HuT,et al.Adhesive hemostatic conducting injectable composite hydrogels with sustained drug release and photothermal antibacterial activity to promote full-thickness skin regeneration during wound healing[J].Small,2019,15(12):e1900046.DOI: 10.1002/smll.201900046.
    [14]
    TangP,HanL,LiP,et al.Mussel-inspired electroactive and antioxidative scaffolds with incorporation of polydopamine-reduced graphene oxide for enhancing skin wound healing[J].ACS Appl Mater Interfaces,2019,11(8):7703-7714.DOI: 10.1021/acsami.8b18931.
    [15]
    HeJ,ShiM,LiangY,et al.Conductive adhesive self-healing nanocomposite hydrogel wound dressing for photothermal therapy of infected full-thickness skin wounds[J].Chem Eng J,2020,394(8):124888.DOI: 10.1016/j.cej.2020.124888.
    [16]
    LiangY,ChenB,LiM,et al.Injectable antimicrobial conductive hydrogels for wound disinfection and infectious wound healing[J].Biomacromolecules,2020,21(5):1841-1852.DOI: 10.1021/acs.biomac.9b01732.
    [17]
    HuC,LongL,CaoJ,et al.Dual-crosslinked mussel-inspired smart hydrogels with enhanced antibacterial and angiogenic properties for chronic infected diabetic wound treatment via pH-responsive quick cargo release[J].Chem Eng J,2021,411: 128564.DOI: 10.1016/j.cej.2021.128564.
    [18]
    BlacklowSO,LiJ,FreedmanBR,et al.Bioinspired mechanically active adhesive dressings to accelerate wound closure[J].Sci Adv,2019,5(7):eaaw3963.DOI: 10.1126/sciadv.aaw3963.
    [19]
    ZhaoY,LiZ,SongS,et al.Skin‐inspired antibacterial conductive hydrogels for epidermal sensors and diabetic foot wound dressings[J]. Adv Funct Mater,2019,29(31):1901474.DOI: 10.1002/adfm.201901474.
    [20]
    WangS,YuanL,XuZ,et al.Functionalization of an electroactive self-healing polypyrrole-grafted gelatin-based hydrogel by incorporating a polydopamine@AgNP nanocomposite[J].ACS Appl Bio Mater,2021,4(7):5797-5808.DOI: 10.1021/acsabm.1c00548.
    [21]
    LiuC,LeiF,LiP,et al.A review on preparations, properties, and applications of cis-ortho-hydroxyl polysaccharides hydrogels crosslinked with borax[J].Int J Biol Macromol,2021,182:1179-1191.DOI: 10.1016/j.ijbiomac.2021.04.090.
    [22]
    LeiH,FanD.Conductive, adaptive, multifunctional hydrogel combined with electrical stimulation for deep wound repair[J].Chem Eng J,2021,421 Pt 1:129578.DOI: 10.1016/j.cej.2021.129578.
    [23]
    ZhangM,DengF,TangL,et al.Super-ductile, injectable, fast self-healing collagen-based hydrogels with multi-responsive and accelerated wound-repair properties[J]. Chem Eng J,2021,405:126756.DOI: 10.1016/j.cej.2020.126756.
    [24]
    陈跃华,徐俊,徐兰举,等.水凝胶敷料对糖尿病足创面的促愈合作用研究进展[J].中华烧伤与创面修复杂志,2022,38(1):95-98.DOI: 10.3760/cma.j.cn501120-20200827-00393.
    [25]
    LuY,WangY,ZhangJ,et al.In-situ doping of a conductive hydrogel with low protein absorption and bacterial adhesion for electrical stimulation of chronic wounds[J].Acta Biomater,2019,89:217-226.DOI: 10.1016/j.actbio.2019.03.018.
    [26]
    WuC,LongL,ZhangY,et al.Injectable conductive and angiogenic hydrogels for chronic diabetic wound treatment[J].J Control Release,2022,344:249-260.DOI: 10.1016/j.jconrel.2022.03.014.
    [27]
    ZhangJ,WuC,XuY,et al.Highly stretchable and conductive self-healing hydrogels for temperature and strain sensing and chronic wound treatment[J].ACS Appl Mater Interfaces,2020,12(37):40990-40999.DOI: 10.1021/acsami.0c08291.
    [28]
    WuC,ShenL,LuY,et al.Intrinsic antibacterial and conductive hydrogels based on the distinct bactericidal effect of polyaniline for infected chronic wound healing[J].ACS Appl Mater Interfaces,2021,13(44):52308-52320.DOI: 10.1021/acsami.1c14088.
    [29]
    曹望北,高长有.多功能水凝胶敷料治疗糖尿病致慢性创面的研究进展[J].中华烧伤杂志,2021,37(11):1090-1098.DOI: 10.3760/cma.j.cn501120-20210715-00249.
    [30]
    WuX,HeW,MuX,et al.Macrophage polarization in diabetic wound healing[J/OL].Burns Trauma,2022,10:tkac051[2023-01-11].https://pubmed.ncbi.nlm.nih.gov/36601058/.DOI: 10.1093/burnst/tkac051.
    [31]
    LiuY,SeguraT.Biomaterials-mediated regulation of macrophage cell fate[J].Front Bioeng Biotechnol,2020,8:609297.DOI: 10.3389/fbioe.2020.609297.
    [32]
    LiuP,JinK,ZongY,et al.Ionic liquid functionalized injectable and conductive hyaluronic acid hydrogels for the efficient repair of diabetic wounds under electrical stimulation[J].Biomater Sci,2022,10(7):1795-1802.DOI: 10.1039/d2bm00026a.
    [33]
    XiaS,WengT,JinR,et al.Curcumin-incorporated 3D bioprinting gelatin methacryloyl hydrogel reduces reactive oxygen species-induced adipose-derived stem cell apoptosis and improves implanting survival in diabetic wounds[J/OL].Burns Trauma,2022,10:tkac001[2023-01-11].https://doi.org/ 10.1093/burnst/tkac001.DOI: 10.1093/burnst/tkac001.
    [34]
    NakkalaJR,LiZ,AhmadW,et al.Immunomodulatory biomaterials and their application in therapies for chronic inflammation-related diseases[J].Acta Biomater,2021,123:1-30.DOI: 10.1016/j.actbio.2021.01.025.
    [35]
    HaoY,ZhaoW,ZhangH,et al.Carboxymethyl chitosan-based hydrogels containing fibroblast growth factors for triggering diabetic wound healing[J].Carbohydr Polym,2022,287:119336.DOI: 10.1016/j.carbpol.2022.119336.
    [36]
    LeeYH,HongYL,WuTL.Novel silver and nanoparticle-encapsulated growth factor co-loaded chitosan composite hydrogel with sustained antimicrobility and promoted biological properties for diabetic wound healing[J].Mater Sci Eng C Mater Biol Appl,2021,118:111385.DOI: 10.1016/j.msec.2020.111385.
    [37]
    CaoW,PengS,YaoY,et al.A nanofibrous membrane loaded with doxycycline and printed with conductive hydrogel strips promotes diabetic wound healing in vivo[J].Acta Biomater,2022,152:60-73.DOI: 10.1016/j.actbio.2022.08.048.
    [38]
    WalkerBW,LaraRP,MogadamE,et al.Rational design of microfabricated electroconductive hydrogels for biomedical applications[J].Prog Polym Sci,2019,92:135-157.DOI: 10.1016/j.progpolymsci.2019.02.007.
    [39]
    LiangY,LiM,YangY,et al.pH/glucose dual responsive metformin release hydrogel dressings with adhesion and self-healing via dual-dynamic bonding for athletic diabetic foot wound healing[J].ACS Nano,2022,16(2):3194-3207.DOI: 10.1021/acsnano.1c11040.
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