Email Alerts
RSS
Volume 40 Issue 5
May  2024
Turn off MathJax
Article Contents
Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2024  >  40(5): 401-406
Wang DL,Qi F.Exploring wound healing from the perspective of circadian rhythm regulation[J].Chin J Burns Wounds,2024,40(5):401-406.DOI: 10.3760/cma.j.cn501225-20240122-00027.
Citation: Wang DL,Qi F.Exploring wound healing from the perspective of circadian rhythm regulation[J].Chin J Burns Wounds,2024,40(5):401-406.DOI: 10.3760/cma.j.cn501225-20240122-00027.
shu

Exploring wound healing from the perspective of circadian rhythm regulation

doi: 10.3760/cma.j.cn501225-20240122-00027

  • Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China

Funds:

Regional Science Foundation Project of National Natural Science Foundation of China 82160379

General Program of National Natural Science Foundation of China 82072195

Collaborative Innovation Center of Chinese Ministry of Education and Guizhou Province 2020-39

Science and Technology Project of Guizhou Province of China 2020-4Y148

More Information
    Abstract
  • Wound healing is a complex and finely regulated biological process involving a variety of cell types, such as immune cells, fibroblasts, keratinocytes, endothelial cells, and stem cells. In recent years, scientific research has unveiled the significant role of circadian rhythms in the regulation of wound healing process. Although the molecular mechanisms by which circadian rhythms precisely regulate wound healing are not yet fully understood, accumulating evidence has revealed that some key signals and cellular functions play crucial roles in the circadian rhythm regulation of wound healing. A deeper understanding of these mechanisms is important not only to uncover the basic biological processes of wound healing, but also to develop new therapeutic strategies, such as regulating circadian rhythms to guide medication and optimize trauma treatment. By reviewing the current research results on circadian rhythm regulation of wound healing, this paper aims to provide a comprehensive perspective on this emerging field and provide valuable insights for future research directions.

     

    • FullText(HTML)
  • loading
    • References(50)
  • [1]
    魏亚婷,吴军.创面修复中的皮肤组织再生研究进展[J].中华烧伤杂志,2021,37(7):670-674.DOI: 10.3760/cma.j.cn501120-20200604-00296.
    [2]
    ParvanianS,Coelho-RatoLS,PattesonAE,et al.Vimentin takes a hike - emerging roles of extracellular vimentin in cancer and wound healing[J].Curr Opin Cell Biol,2023,85:102246.DOI: 10.1016/j.ceb.2023.102246.
    [3]
    JereSW,AbrahamseH,HoureldNN.Interaction of the AKT and β-catenin signalling pathways and the influence of photobiomodulation on cellular signalling proteins in diabetic wound healing[J].J Biomed Sci,2023,30(1):81.DOI: 10.1186/s12929-023-00974-8.
    [4]
    FlemmingJP,WermuthPJ,MahoneyMG.Extracellular vesicles in the skin microenvironment: emerging roles as biomarkers and therapeutic tools in dermatologic health and disease[J].J Invest Dermatol,2024,144(2):225-233.DOI: 10.1016/j.jid.2023.08.024.
    [5]
    王达利.关于间充质干细胞外泌体与创面微环境研究的一些思考[J].中华烧伤与创面修复杂志,2023,39(2):101-105.DOI: 10.3760/cma.j.cn501225-20230112-00014.
    [6]
    谢挺,倪鹏文,韩春茂,等.中国创面修复学科发展的新阶段:规范及融合与转化[J].中华烧伤与创面修复杂志,2023,39(11):1001-1005.DOI: 10.3760/cma.j.cn501225-20230627-00231.
    [7]
    HoyleNP,SeinkmaneE,PutkerM,et al.Circadian actin dynamics drive rhythmic fibroblast mobilization during wound healing[J].Sci Transl Med,2017,9(415):eaal2774.DOI: 10.1126/scitranslmed.aal2774.
    [8]
    MokH,OstendorfE,GanningerA,et al.Circadian immunity from bench to bedside: a practical guide[J].J Clin Invest,2024,134(3):e175706.DOI: 10.1172/JCI175706.
    [9]
    NaveedM,ChaoOY,HillJW,et al.Circadian neurogenetics and its implications in neurophysiology, behavior, and chronomedicine[J].Neurosci Biobehav Rev,2024,157:105523.DOI: 10.1016/j.neubiorev.2023.105523.
    [10]
    ZhangR,LahensNF,BallanceHI,et al.A circadian gene expression atlas in mammals: implications for biology and medicine[J].Proc Natl Acad Sci U S A,2014,111(45):16219-16224.DOI: 10.1073/pnas.1408886111.
    [11]
    LiuXL,DuanZ,YuM,et al.Epigenetic control of circadian clocks by environmental signals[J/OL].Trends Cell Biol,2024:S0962-8924(24)00028-X(2024-02-28)[2024-04-10]. https://pubmed.ncbi.nlm.nih.gov/38423855/.DOI:10.1016/j.tcb.2024.02.005.[published online ahead of print].
    [12]
    MiyazakiK,WakabayashiM,ChikahisaS,et al.PER2 controls circadian periods through nuclear localization in the suprachiasmatic nucleus[J].Genes Cells,2007,12(11):1225-1234.DOI: 10.1111/j.1365-2443.2007.01129.x.
    [13]
    MissraA,ErnestB,LohoffT,et al.The circadian clock modulates global daily cycles of mRNA ribosome loading[J].Plant Cell,2015,27(9):2582-2599.DOI: 10.1105/tpc.15.00546.
    [14]
    PutkerM,O'NeillJS.Reciprocal control of the circadian clock and cellular redox state - a critical appraisal[J].Mol Cells,2016,39(1):6-19.DOI: 10.14348/molcells.2016.2323.
    [15]
    KoGY,ShiL,KoML.Circadian regulation of ion channels and their functions[J].J Neurochem,2009,110(4):1150-1169.DOI: 10.1111/j.1471-4159.2009.06223.x.
    [16]
    SanchezSE,KaySA.The plant circadian clock: from a simple timekeeper to a complex developmental manager[J].Cold Spring Harb Perspect Biol,2016,8(12):a027748.DOI: 10.1101/cshperspect.a027748.
    [17]
    EarlyJO,CurtisAM.Immunometabolism: is it under the eye of the clock?[J].Semin Immunol,2016,28(5):478-490.DOI: 10.1016/j.smim.2016.10.006.
    [18]
    FawcettS,Al KassasR,Dykes IM,et al.A time to heal: microRNA and circadian dynamics in cutaneous wound repair[J].Clin Sci (Lond),2022,136(8):579-597.DOI: 10.1042/CS20220011.
    [19]
    PillayJ,den BraberI,VrisekoopN,et al.In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days[J].Blood,2010,116(4):625-627.DOI: 10.1182/blood-2010-01-259028.
    [20]
    Méndez-FerrerS,LucasD,BattistaM,et al.Haematopoietic stem cell release is regulated by circadian oscillations[J].Nature,2008,452(7186):442-447.DOI: 10.1038/nature06685.
    [21]
    OvadiaS,ÖzcanA,HidalgoA.The circadian neutrophil, inside-out[J].J Leukoc Biol,2023,113(6):555-566.DOI: 10.1093/jleuko/qiad038.
    [22]
    EarlyJO,MenonD,WyseCA,et al.Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2[J].Proc Natl Acad Sci U S A,2018,115(36):E8460-E8468.DOI: 10.1073/pnas.1800431115.
    [23]
    TimmonsGA,CarrollRG,O'SiorainJR,et al.The circadian clock protein BMAL1 acts as a metabolic sensor in macrophages to control the production of pro IL-1β[J].Front Immunol,2021,12:700431.DOI: 10.3389/fimmu.2021.700431.
    [24]
    SatoS,SakuraiT,OgasawaraJ,et al.A circadian clock gene, Rev-erbα, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression[J].J Immunol,2014,192(1):407-417.DOI: 10.4049/jimmunol.1301982.
    [25]
    NakazatoR,MatsudaY,IjazF,et al.Circadian oscillation in primary cilium length by clock genes regulates fibroblast cell migration[J].EMBO Rep,2023,24(12):e56870.DOI: 10.15252/embr.202356870.
    [26]
    FarshadiE,YanJ,LeclereP,et al.The positive circadian regulators CLOCK and BMAL1 control G2/M cell cycle transition through Cyclin B1[J].Cell Cycle,2019,18(1):16-33.DOI: 10.1080/15384101.2018.1558638.
    [27]
    SasakiH,HokugoA,WangL,et al.Neuronal PAS domain 2 (Npas2)-deficient fibroblasts accelerate skin wound healing and dermal collagen reconstruction[J].Anat Rec (Hoboken),2020,303(6):1630-1641.DOI: 10.1002/ar.24109.
    [28]
    PastarI,StojadinovicO,YinNC,et al.Epithelialization in wound healing: a comprehensive review[J].Adv Wound Care (New Rochelle),2014,3(7):445-464.DOI: 10.1089/wound.2013.0473.
    [29]
    TsujihanaK,TanegashimaK,SantoY,et al.Circadian protection against bacterial skin infection by epidermal CXCL14-mediated innate immunity[J].Proc Natl Acad Sci U S A,2022,119(25):e2116027119.DOI: 10.1073/pnas.2116027119.
    [30]
    BigliardiP,JunnarkarS,MarkaleC,et al.The opioid receptor influences circadian rhythms in human keratinocytes through the β-arrestin pathway[J].Cells,2024,13(3):232.DOI: 10.3390/cells13030232.
    [31]
    BhatwadekarAD,BeliE,DiaoY,et al.Conditional deletion of Bmal1 accentuates microvascular and macrovascular injury[J].Am J Pathol,2017,187(6):1426-1435.DOI: 10.1016/j.ajpath.2017.02.014.
    [32]
    TakaguriA,SasanoJ,AkihiroO,et al.The role of circadian clock gene BMAL1 in vascular proliferation[J].Eur J Pharmacol,2020,872:172924.DOI: 10.1016/j.ejphar.2020.172924.
    [33]
    YujraVQ,SilveiraEJDD,RibeiroDA,et al.Clock gene Per2 modulates epidermal tissue repair in vivo[J].J Cell Biochem,2024,125(2):e30513.DOI: 10.1002/jcb.30513.
    [34]
    WangM,QiuC,PanQ,et al.Role of nuclear receptor subfamily 1 group D member 1 in the proliferation, migration of vascular smooth muscle cell, and vascular intimal hyperplasia[J].J Cardiovasc Pharmacol,2023,82(3):221-228.DOI: 10.1097/FJC.0000000000001446.
    [35]
    TsuzukiK,ShimizuY,SuzukiJ,et al.Adverse effect of circadian rhythm disorder on reparative angiogenesis in hind limb ischemia[J].J Am Heart Assoc,2021,10(16):e020896.DOI: 10.1161/JAHA.121.020896.
    [36]
    YagitaK,HorieK,KoinumaS,et al.Development of the circadian oscillator during differentiation of mouse embryonic stem cells in vitro[J].Proc Natl Acad Sci U S A,2010,107(8):3846-3851.DOI: 10.1073/pnas.0913256107.
    [37]
    KanekoH,KaitsukaT,TomizawaK.Artificial induction of circadian rhythm by combining exogenous BMAL1 expression and polycomb repressive complex 2 inhibition in human induced pluripotent stem cells[J].Cell Mol Life Sci,2023,80(8):200.DOI: 10.1007/s00018-023-04847-z.
    [38]
    HsuYC,FuchsE.Building and maintaining the skin[J].Cold Spring Harb Perspect Biol,2022,14(7):a040840.DOI: 10.1101/cshperspect.a040840.
    [39]
    ZagniC,AlmeidaLO,BalanT,et al.PTEN mediates activation of core clock protein BMAL1 and accumulation of epidermal stem cells[J].Stem Cell Reports,2017,9(1):304-314.DOI: 10.1016/j.stemcr.2017.05.006.
    [40]
    LinKK,KumarV,GeyfmanM,et al.Circadian clock genes contribute to the regulation of hair follicle cycling[J].PLoS Genet,2009,5(7):e1000573.DOI: 10.1371/journal.pgen.1000573.
    [41]
    GreenbergEN,MarshallME,JinS,et al.Circadian control of interferon-sensitive gene expression in murine skin[J].Proc Natl Acad Sci U S A,2020,117(11):5761-5771.DOI: 10.1073/pnas.1915773117.
    [42]
    JanichP,PascualG,Merlos-SuárezA,et al.The circadian molecular clock creates epidermal stem cell heterogeneity[J].Nature,2011,480(7376):209-214.DOI: 10.1038/nature10649.
    [43]
    GeyfmanM,KumarV,LiuQ,et al.Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis[J].Proc Natl Acad Sci U S A,2012,109(29):11758-11763.DOI: 10.1073/pnas.1209592109.
    [44]
    RogersEH,FawcettSA,Pekovic-VaughanV,et al.Comparing circadian dynamics in primary derived stem cells from different sources of human adult tissue[J].Stem Cells Int,2017,2017:2057168.DOI: 10.1155/2017/2057168.
    [45]
    HeY,LinF,ChenY,et al.Overexpression of the circadian clock gene Rev-erbα affects murine bone mesenchymal stem cell proliferation and osteogenesis[J].Stem Cells Dev,2015,24(10):1194-1204.DOI: 10.1089/scd.2014.0437.
    [46]
    ZhengJ,ZhangL,TanZ,et al.Bmal1- and Per2-mediated regulation of the osteogenic differentiation and proliferation of mouse bone marrow mesenchymal stem cells by modulating the Wnt/β-catenin pathway[J].Mol Biol Rep,2022,49(6):4485-4501.DOI: 10.1007/s11033-022-07292-6.
    [47]
    DoiM,HirayamaJ,Sassone-CorsiP.Circadian regulator CLOCK is a histone acetyltransferase[J].Cell,2006,125(3):497-508.DOI: 10.1016/j.cell.2006.03.033.
    [48]
    LiuM,ZhangZ,ChenY,et al.Circadian clock and lipid metabolism disorders: a potential therapeutic strategy for cancer[J].Front Endocrinol (Lausanne),2023,14:1292011.DOI: 10.3389/fendo.2023.1292011.
    [49]
    LeviF,Le LouarnC,ReinbergA.Timing optimizes sustained-release indomethacin treatment of osteoarthritis[J].Clin Pharmacol Ther,1985,37(1):77-84.DOI: 10.1038/clpt.1985.15.
    [50]
    DallmannR,OkyarA,LéviF.Dosing-time makes the poison: circadian regulation and pharmacotherapy[J].Trends Mol Med,2016,22(5):430-445.DOI: 10.1016/j.molmed.2016.03.004.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (2058) PDF downloads(31) Cited by()
    Proportional views
    Related

    Copyright © Chinese Journal of Burns京ICP备07035254号-14

    E-mail：shaoshangzazhi@163.com

    Website：https://zhsszz.xml-journal.net/

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return