Effects of baicalin on ferroptosis of mouse fibroblasts under high glucose treatment and its mechanism

Gong Zheng; Zhang Xiaowei; Li Xiaomei; Yin Zhimin; Bai Limin; Wang Jiaxi; Han Yujia; Xu Shuangyi; Yu Lu; Xu Gang

doi:10.3760/cma.j.cn501225-20240425-00151

Volume 41 Issue 3

Mar. 2025

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Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2025 > 41(3): 277-285

Zhou QY,Li JY,Cao YM,et al.Effects of thioredoxin reductase 1 on ferroptosis and immune function of dendritic cells in septic mice[J].Chin J Burns Wounds,2025,41(3):212-221.DOI: 10.3760/cma.j.cn501225-20241118-00451.

Citation:

Gong Z,Zhang XW,Li XM,et al.Effects of baicalin on ferroptosis of mouse fibroblasts under high glucose treatment and its mechanism[J].Chin J Burns Wounds,2025,41(3):277-285.DOI: 10.3760/cma.j.cn501225-20240425-00151.

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Effects of baicalin on ferroptosis of mouse fibroblasts under high glucose treatment and its mechanism

doi: 10.3760/cma.j.cn501225-20240425-00151

Department of Burns and Plastic Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Northern Jiangsu People's Hospital, Yangzhou 225009, China

Funds:

Medical Health Science and Technology Project of Hangzhou B20200041

Project Supported by Special Scientific Research Fund of Yangzhou Health Commission 2023-2-18

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Corresponding author: Xu Gang, Email: drxugang@126.com
Received Date: 2024-04-25

Abstract

Abstract

Objective To investigate the effects of baicalin on ferroptosis of mouse fibroblasts (Fbs) under high glucose treatment and its mechanism, and to provide a basis for the treatment of diabetic wounds. Methods The study was an experimental study. Mouse Fbs were collected and divided into control group with conventional culture, high glucose group treated with glucose at final molarity of 30.0 mmol/L, and low baicalin group and high baicalin group pretreated with baicalin at final molarties of 5 and 10 μmol/L respectively and then treated as that in high glucose group. After 48 h of culture, the cell survival rate was detected by the cell counting kit-8, the reactive oxygen species level in cells was detected by the fluorescent probe method, the levels of malondialdehyde, glutathione, and ferrous ion in cells were detected by colorimetry, and the protein expression levels of solute carrier family 7 member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4) in cells and nuclear factor-erythroid 2-related factor 2 (Nrf2) in cytoplasm and nucleus were detected by Western blotting. Another batch of mouse Fbs were collected and divided into control group, high glucose group, high baicalin group, and high baicalin+ML385 group. The cells in the first three groups were treated as before, the cells in the last group were pretreated with baicalin and ML385 of Nrf2 inhibitor at final molarties of 10 μmol/L and then treated as that in high glucose group. After 48 h of culture, the protein expression levels of SLC7A11 and GPX4 in cells and the protein expression level of Nrf2 in cytoplasm and nucleus were detected as before. Except that the sample number in detecting SLC7A11 and GPX4 was 4, the sample number in detecting other indexes was 3. Results After 48 h of culture, the cell survival rates in control group, high glucose group, low baicalin group, and high baicalin group were (100.0±10.7)%, (70.0±5.0)%, (80.9±3.2)%, and (91.4±1.9)%, respectively. Compared with those in control group, the cell survival rate, the glutathione level, and SLC7A11 and GPX4 protein expression levels in cells, and nuclear Nrf2 protein expression level were significantly decreased in high glucose group (P<0.05), and the levels of reactive oxygen species, malondialdehyde, and ferrous ion in cells, and cytoplasmic Nrf2 protein expression level were significantly increased in high glucose group (P<0.05). Compared with those in high glucose group, the cell survival rate, glutathione level, SLC7A11 and GPX4 protein expression levels in cells, and nuclear Nrf2 protein expression level in low baicalin group and high baicalin group were significantly increased (P<0.05), the reactive oxygen species and ferrous ion levels in cells, and cytoplasmic Nrf2 protein expression level in low baicalin group and high baicalin group were significantly decreased (P<0.05), and the malondialdehyde level in cells in high baicalin group was significantly decreased (P<0.05). Compared with those in low baicalin group, the cell survival rate, glutathione level, SLC7A11 and GPX4 protein expression levels in cells, and nuclear Nrf2 protein expression level in high baicalin group were significantly increased (P<0.05), and the reactive oxygen species, malondialdehyde, and ferrous ion levels in cells, and cytoplasmic Nrf2 protein expression level in high baicalin group were significantly decreased (P<0.05). After 48 h of culture, compared with those in control group, the nuclear Nrf2 protein expression level and SLC7A11 and GPX4 protein expression levels in cells were significantly decreased (P<0.05), and the cytoplasmic Nrf2 protein expression level was significantly increased in high glucose group (P<0.05); compared with those in high glucose group, the cytoplasmic Nrf2 protein expression level was significantly decreased (P<0.05), and the nuclear Nrf2 protein expression level and SLC7A11 and GPX4 protein expression levels in cells were significantly increased in high baicalin group (P<0.05); compared with those in high baicalin group, the cytoplasmic Nrf2 protein expression level was significantly increased (P<0.05), and the nuclear Nrf2 protein expression level and SLC7A11 and GPX4 protein expression levels in cells were significantly decreased in high baicalin+ML385 group (P<0.05). Conclusions Baicalin can inhibit the occurrence of ferroptosis in cells by activating the Nrf2 signaling pathway and up-regulating the expressions of proteins related to SLC7A11/GPX4 axis in Fbs in high glucose treatment, thus increasing the cell survival rate.
- Drugs, Chinese herbal,
- Fibroblasts,
- Diabetes mellitus,
- Lipid peroxides,
- Baicalin,
- Ferroptosis,
- Nuclear factor-erythroid 2-related factor 2

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References

[1]	LiS,LiY,WuZ,et al.Diabetic ferroptosis plays an important role in triggering on inflammation in diabetic wound[J].Am J Physiol Endocrinol Metab,2021,321(4):E509-E520.DOI: 10.1152/ajpendo.00042.2021.
[2]	YangR,ZhouS,HuangJ,et al.The role of Q10 engineering mesenchymal stem cell-derived exosomes in inhibiting ferroptosis for diabetic wound healing[J/OL].Burns Trauma,2024,12:tkae054[2025-01-25]. https://pubmed.ncbi.nlm.nih.gov/39600692/. DOI: 10.1093/burnst/tkae054.
[3]	LiuL,LiuD.Bioengineered mesenchymal stem cell-derived exosomes: emerging strategies for diabetic wound healing[J/OL].Burns Trauma,2024,12:tkae030[2025-01-25].https://pubmed.ncbi.nlm.nih.gov/39015252/. DOI: 10.1093/burnst/tkae030.
[4]	DingX,YangC,LiY,et al.Reshaped commensal wound microbiome via topical application of Calvatia gigantea extract contributes to faster diabetic wound healing[J/OL].Burns Trauma,2024,12:tkae037[2025-01-25]. https://pubmed.ncbi.nlm.nih.gov/39224840/. DOI: 10.1093/burnst/tkae037.
[5]	林崴仪,戈成旺,唐枭伟,等.阿克曼嗜黏液菌外膜蛋白1100促进糖尿病大鼠创面愈合[J].组织工程与重建外科杂志,2023,19(4):358-365.DOI: 10.3969/j.issn.1673-0364.2023.04.005.
[6]	GaoSQ,ChangC,LiJJ,et al.Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesis[J].Drug Deliv,2018,25(1):1779-1789.DOI: 10.1080/10717544.2018.1513608.
[7]	屠卓隆,林才. 姜黄素对糖尿病创面的促愈合作用及其机制研究进展[J]. 中华烧伤杂志,2021,37(4):391-394. DOI: 10.3760/cma.j.cn501120-20200224-00089.
[8]	HuSC,LanCE.High-glucose environment disturbs the physiologic functions of keratinocytes: focusing on diabetic wound healing[J].J Dermatol Sci,2016,84(2):121-127.DOI: 10.1016/j.jdermsci.2016.07.008.
[9]	李媛媛,姚小玲,曲彦洁,等.中药通过干预铁死亡治疗帕金森病的机制研究进展[J].内科理论与实践,2024,19(5):351-356.DOI: 10.16138/j.1673-6087.2024.05.13.
[10]	JiangX,StockwellBR,ConradM.Ferroptosis: mechanisms, biology and role in disease[J].Nat Rev Mol Cell Biol,2021,22(4):266-282.DOI: 10.1038/s41580-020-00324-8.
[11]	BaiC,LiT,SunQ,et al.Protective effect of baicalin against severe burn-induced remote acute lung injury in rats[J].Mol Med Rep,2018,17(2):2689-2694.DOI: 10.3892/mmr.2017.8120.
[12]	ZhangHJ,LuoJZ,LanCL,et al.Baicalin protects against hepatocyte injury caused by aflatoxin B₁ via the TP53-related ferroptosis pathway[J].Ecotoxicol Environ Saf,2024,281:116661.DOI: 10.1016/j.ecoenv.2024.116661.
[13]	ZhaoS,HuangM,YanL,et al.Exosomes derived from baicalin-pretreated mesenchymal stem cells alleviate hepatocyte ferroptosis after acute liver injury via the Keap1-NRF2 pathway[J].Oxid Med Cell Longev,2022,2022:8287227.DOI: 10.1155/2022/8287227.
[14]	ZhangX,HuangJ,ZhaoJ,et al.Exosome-mimetic vesicles derived from fibroblasts carrying matrine for wound healing[J/OL].Burns Trauma,2024,12:tkae015[2025-01-25]. https://pubmed.ncbi.nlm.nih.gov/38752203/. DOI: 10.1093/burnst/tkae015.
[15]	ZhuY,RuanCX,WangJ,et al.High glucose inhibits the survival of HRMCs and its mechanism[J].Eur Rev Med Pharmacol Sci,2022,26(16):5683-5688.DOI: 10.26355/eurrev_202208_29502.
[16]	黄伟琨,徐秋艳,周婷.黄芩苷抑制脂多糖促巨噬细胞氧化应激损伤作用的研究[J].国际口腔医学杂志,2022,42(5):521-528.DOI: 10.7518/gjkq.2022080.
[17]	LiuX,MaY,LuoL,et al.Dihydroquercetin suppresses cigarette smoke induced ferroptosis in the pathogenesis of chronic obstructive pulmonary disease by activating Nrf2-mediated pathway[J].Phytomedicine,2022,96:153894.DOI: 10.1016/j.phymed.2021.153894.
[18]	母义明,臧丽.干细胞——糖尿病治疗的新选择[J].解放军医学杂志,2015,40(7):515-518.DOI: 10.11855/j.issn.0577-7402.2015.07.01.
[19]	曹望北,高长有. 多功能水凝胶敷料治疗糖尿病致慢性创面的研究进展[J]. 中华烧伤杂志,2021,37(11):1090-1098.DOI: 10.3760/cma.j.cn501120-20210715-00249.
[20]	王一希,陈俊杰,岑瑛,等. 脂肪间充质干细胞外泌体促进糖尿病创面愈合的研究进展[J]. 中华烧伤与创面修复杂志,2022,38(5):491-495. DOI: 10.3760/cma.j.cn501120-20210218-00057.
[21]	彭源,卢毅飞,邓君,等. 氧化铜纳米酶对糖尿病小鼠全层皮肤缺损创面修复的作用及其机制[J]. 中华烧伤杂志,2020,36(12):1139-1148. DOI: 10.3760/cma.j.cn501120-20200929-00426.
[22]	WangQ,ZhuG,CaoX,et al.Blocking AGE-RAGE signaling improved functional disorders of macrophages in diabetic wound[J].J Diabetes Res,2017,2017:1428537.DOI: 10.1155/2017/1428537.
[23]	BanerjeeA,SinghP,SheikhPA,et al.Simultaneous regulation of AGE/RAGE signaling and MMP-9 expression by an immunomodulating hydrogel accelerates healing in diabetic wounds[J].Biomater Adv,2024,163:213937.DOI: 10.1016/j.bioadv.2024.213937.
[24]	张玉基于铁死亡通路探讨Ferrostatin-1对高糖环境下溃疡创面的修复作用及机制研究天津天津医科大学2020 张玉. 基于铁死亡通路探讨Ferrostatin-1对高糖环境下溃疡创面的修复作用及机制研究[D]. 天津:天津医科大学,2020.
[25]	陈丽富血小板血浆通过抑制铁死亡促进糖尿病溃疡修复合肥安徽医科大学2023 陈丽. 富血小板血浆通过抑制铁死亡促进糖尿病溃疡修复[D]. 合肥:安徽医科大学,2023.
[26]	陆会平,党裔武,陈罡.铁死亡抑制蛋白1在人类疾病中的作用机制研究进展[J].解放军医学杂志,2021,46(7):731-736.DOI: 10.11855/j.issn.0577-7402.2021.07.14.
[27]	YuX,LiuZ,YuY,et al.Hesperetin promotes diabetic wound healing by inhibiting ferroptosis through the activation of SIRT3[J].Phytother Res,2024,38(3):1478-1493.DOI: 10.1002/ptr.8121.
[28]	LiuJ,KangR,TangD.Signaling pathways and defense mechanisms of ferroptosis[J].FEBS J,2022,289(22):7038-7050.DOI: 10.1111/febs.16059.
[29]	RochetteL,DogonG,RigalE,et al.Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis[J].Int J Mol Sci,2022,24(1):449.DOI: 10.3390/ijms24010449.
[30]	HadianK,StockwellBR.SnapShot: ferroptosis[J].Cell,2020,181(5):1188-1188.e1.DOI: 10.1016/j.cell.2020.04.039.
[31]	StockwellBR,Friedmann AngeliJP,BayirH,et al.Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease[J].Cell,2017,171(2):273-285.DOI: 10.1016/j.cell.2017.09.021.
[32]	曹盼,张樱山,魏学明,等.黄芩苷抗氧化作用机制研究进展[J].西部中医药,2021,34(2):134-137.DOI: 10.12174/j.issn.2096-9600.2021.02.36.
[33]	ShiL,HaoZ,ZhangS,et al.Baicalein and baicalin alleviate acetaminophen-induced liver injury by activating Nrf2 antioxidative pathway: the involvement of ERK1/2 and PKC[J].Biochem Pharmacol,2018,150:9-23.DOI: 10.1016/j.bcp.2018.01.026.
[34]	WenRJ,DongX,ZhuangHW,et al.Baicalin induces ferroptosis in osteosarcomas through a novel Nrf2/xCT/GPX4 regulatory axis[J].Phytomedicine,2023,116:154881.DOI: 10.1016/j.phymed.2023.154881.
[35]	YuH,ChenB,RenQ.Baicalin relieves hypoxia-aroused H9c2 cell apoptosis by activating Nrf2/HO-1-mediated HIF1α/BNIP3 pathway[J].Artif Cells Nanomed Biotechnol,2019,47(1):3657-3663.DOI: 10.1080/21691401.2019.1657879.
[36]	ShiH,QiaoF,LuW,et al.Baicalin improved hepatic injury of NASH by regulating NRF2/HO-1/NRLP3 pathway[J].Eur J Pharmacol,2022,934:175270.DOI: 10.1016/j.ejphar.2022.175270.
[37]	LiH,CongX,YuW,et al.Baicalin inhibits oxidative injures of mouse uterine tissue induced by acute heat stress through activating the Keap1/Nrf2 signaling pathway[J].Res Vet Sci,2022,152:717-725.DOI: 10.1016/j.rvsc.2022.10.005.
[38]	SunYK,ZhangYF,XieL,et al.Progress in the treatment of drug-induced liver injury with natural products[J].Pharmacol Res,2022,183:106361.DOI: 10.1016/j.phrs.2022.106361.
[39]	MaL,WuF,ShaoQ,et al.Baicalin alleviates oxidative stress and inflammation in diabetic nephropathy via Nrf2 and MAPK signaling pathway[J].Drug Des Devel Ther,2021,15:3207-3221.DOI: 10.2147/DDDT.S319260.
[40]	胡佳,张海霞,苏婉露,等.间充质干细胞对2型糖尿病小鼠糖尿病肾病进展的影响及其机制[J].解放军医学杂志,2023,48(4):383-393.DOI: 10.11855/j.issn.0577-7402.2023.04.0383.
[41]	刘兴梅,沈燕,班晓霞,等.PTEN对糖尿病肾病肾间质纤维化的作用及其机制[J].解放军医学杂志,2022,47(5):435-441.DOI: 10.11855/j.issn.0577-7402.2022.05.0435.
[42]	毕礼明,王朝晖. 糖尿病肾病发病机制研究进展[J]. 内科理论与实践,2023,18(3):201-205. DOI: 10.16138/j.1673-6087.2023.03.014.
[43]	ChenG,ChenX,NiuC,et al.Baicalin alleviates hyperglycemia-induced endothelial impairment 1 via Nrf2[J].J Endocrinol,2018:JOE-18-0457.R1.DOI: 10.1530/JOE-18-0457.
[44]	WangX,YuJY,SunY,et al.Baicalin protects LPS-induced blood-brain barrier damage and activates Nrf2-mediated antioxidant stress pathway[J].Int Immunopharmacol,2021,96:107725.DOI: 10.1016/j.intimp.2021.107725.
[45]	WangX,ChangX,ZhanH,et al.Curcumin and Baicalin ameliorate ethanol-induced liver oxidative damage via the Nrf2/HO-1 pathway[J].J Food Biochem,2020,44(10):e13425.DOI: 10.1111/jfbc.13425.
[46]	施彦,易亮,张伟强,等.黄芩素对糖尿病小鼠全层皮肤缺损创面愈合的影响及其机制[J].中华烧伤与创面修复杂志,2024,40(11):1085-1094.DOI: 10.3760/cma.j.cn501225-20231104-00179.

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Effects of baicalin on ferroptosis of mouse fibroblasts under high glucose treatment and its mechanism

doi: 10.3760/cma.j.cn501225-20240425-00151

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Effects of baicalin on ferroptosis of mouse fibroblasts under high glucose treatment and its mechanism

doi: 10.3760/cma.j.cn501225-20240425-00151

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通讯作者: 陈斌, bchen63@163.com

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