Research advances on inflammatory responses involved in keloid development
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摘要:
瘢痕疙瘩是由感染、创伤、手术诱发或不明诱因导致机体自发形成的过度增生的病理性瘢痕,是机体对真皮损伤的过度组织反应。本文从炎症诱发因素、炎症细胞、炎症介质、炎症效应器及其影响因素等方面介绍了炎症反应参与瘢痕疙瘩形成及通过抑制炎症反应治疗瘢痕疙瘩的研究进展,这些研究结果提示炎症反应既是创面正常愈合的必要环节,也是瘢痕疙瘩形成和发展的关键因素。
Abstract:Keloid is a hyperplastic pathological scar of body caused by infection, trauma, and surgery or formed spontaneously for unknown reasons. It is an excessive tissue response of body to dermal injury. The paper introduces the research advances on inflammatory responses involved in keloid development and keloid treatment by inhibiting inflammatory responses from the aspects of inflammation inducing factors, inflammatory cells, inflammatory mediators, inflammatory effectors, and influencing factors of inflammatory responses. The research results suggest that inflammatory responses are not only essential process to normal wound healing, but also key factors on keloid formation and development.
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Key words:
- Keloid /
- Inflammatory responses /
- Inflammatory cells /
- Inflammatory mediator /
- Pathogenesis
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