昼夜节律基因在创面愈合中的作用机制研究进展

滕鹰; 祁放; 徐广超; 王达利

doi:10.3760/cma.j.cn501225-20230831-00071

昼夜节律基因在创面愈合中的作用机制研究进展

doi: 10.3760/cma.j.cn501225-20230831-00071

遵义医科大学附属医院烧伤整形外科,遵义　　563003

基金项目:

国家自然科学基金地区科学基金项目 82160379

国家自然科学基金面上项目 82072195

省部共建协同创新中心项目 2020-39

贵州省科技厅基础研究计划（黔科合基础-ZK[2024]一般 310号） ZK2024-310

详细信息

通讯作者:
王达利,Email：daliwangzy@sina.com

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- 被引次数: 0
出版历程
- 收稿日期: 2023-08-31

Research advances on the mechanism of circadian rhythm genes in wound healing

Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China

Funds:

Regional Science Foundation Project of National Natural Science Foundation of China 82160379

General Program of National Natural Science Foundation of China 82072195

Collaborative Innovation Center of Chinese Ministry of Education 2020-39

Basic Research Project of Guizhou Provincial Department of Science and Technology ZK2024-310

More Information

Corresponding author: Wang Dali, Email: daliwangzy@sina.com

摘要

摘要: 皮肤损伤后的愈合是多种细胞、细胞因子以及细胞外基质相互作用的动态过程,任何一个环节的异常都将影响创面愈合的速度和质量。昼夜节律是生物体内自发形成的周期性振荡循环,在维持内环境稳态和调控生理活动中发挥着重要作用。研究表明昼夜节律基因在创面愈合过程中扮演着关键角色。该综述总结了昼夜节律基因对创面愈合不同阶段的影响及其可能的作用机制,以期为创面愈合提供一个新的视角,并为制订更有效的难愈性创面的治疗策略提供理论依据。
- 昼夜节律 /
- 基因 /
- 皮肤 /
- 创面愈合
Abstract: The healing after skin injury is a dynamic process of the interaction of various cells, cytokines, and extracellular matrix, and the abnormality of any link will affect the speed and quality of wound healing. Circadian rhythm is a spontaneous periodic oscillation cycle in organisms, which plays an important role in maintaining homeostasis and regulating physiological activities. Studies have shown that circadian rhythm genes play a key role in wound healing. This review summarizes the effects of circadian rhythm genes on different stages of wound healing and its possible mechanism of action, in order to provide a new perspective for wound healing and provide theoretical basis for formulating more effective treatment strategies for refractory wounds.
- Circadian rhythm /
- Genes /
- Skin /
- Wound healing
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