缺氧与炎症在创面愈合中扮演的角色

魏在荣; 张演基; 王达利

doi:10.3760/cma.j.cn501225-20240111-00014

缺氧与炎症在创面愈合中扮演的角色

doi: 10.3760/cma.j.cn501225-20240111-00014

遵义医科大学附属医院烧伤整形外科，遵义　　563003

基金项目:

国家自然科学基金地区科学基金项目 82360445

省部共建协同创新中心项目 2020-39

遵义市科技计划项目 2021-3

贵州茅台医院科研与人才培养资金 2022-13

详细信息

通讯作者:
王达利，Email：daliwangzy@sina.com

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- 被引次数: 0
出版历程
- 收稿日期: 2024-01-11

Roles of hypoxia and inflammation in wound healing

Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China

Funds:

Regional Science Foundation Project of National Natural Science Foundation of China 82360445

Collaborative Innovation Center of Chinese Ministry of Education and Guizhou Province 2020-39

Science and Technology Plan Project of Zunyi City 2021-3

Scientific Research and Talent Training Funds of Kweichow Moutai Hospital 2022-13

More Information

Corresponding author: Wang Dali, Email: daliwangzy@sina.com

摘要

摘要: 创面愈合是一个复杂的生物学过程，缺氧和炎症是启动创面愈合和影响创面愈合进程的2个关键因素。缺氧诱导因子1α（HIF-1α）和核因子κB是缺氧和炎症环境下的重要调控因子，缺氧和炎症之间的相互作用本质上由HIF-1α和核因子κB信号通路所介导，二者失调导致的HIF-1α或核因子κB信号通路的异常表达均会影响创面微环境，导致创面异常愈合。该文讨论了缺氧和炎症对创面愈合的影响，强调了缺氧和炎症之间的相互协作对创面愈合的作用，以及二者失调对创面愈合质量的影响，并对目前缺氧和炎症信号通路的干预策略进行总结，同时对未来创面的治疗进行展望。
- 伤口愈合 /
- 炎症 /
- 低氧 /
- 缺氧诱导因子1
Abstract: Wound healing is a complex biological process. Hypoxia and inflammation are the two key factors that initiate wound healing and affect the wound healing process. Hypoxia-inducible factor-1α (HIF-1α) and nuclear factor κB are the important regulators of hypoxia and inflammation. The interaction between hypoxia and inflammation is essentially mediated by HIF-1α and nuclear factor κB signaling pathways. The abnormal expression of HIF-1α or nuclear factor κB signaling pathway caused by the imbalance of hypoxia and inflammation will affect the wound microenvironment and lead to abnormal wound healing. This paper discussed the effects of hypoxia and inflammation on wound healing, emphasized the role of cooperation between hypoxia and inflammation on wound healing and the effect of their imbalance on the quality of wound healing, summarized the current intervention strategies of hypoxia and inflammation signaling pathways, and prospected the treatment of wound in the future.
- Wound healing /
- Inflammation /
- Hypoxia /
- Hypoxia-inducible factor 1
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参考文献(43)

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