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缺氧与炎症在创面愈合中扮演的角色

魏在荣 张演基 王达利

魏在荣, 张演基, 王达利. 缺氧与炎症在创面愈合中扮演的角色[J]. 中华烧伤与创面修复杂志, 2024, 40(6): 1-7. DOI: 10.3760/cma.j.cn501225-20240111-00014.
引用本文: 魏在荣, 张演基, 王达利. 缺氧与炎症在创面愈合中扮演的角色[J]. 中华烧伤与创面修复杂志, 2024, 40(6): 1-7. DOI: 10.3760/cma.j.cn501225-20240111-00014.
Wei Zairong,Zhang Yanji,Wang Dali.Role of hypoxia and inflammation in wound healing[J].Chin J Burns Wounds,2024,40(6):1-7.DOI: 10.3760/cma.j.cn501225-20240111-00014.
Citation: Wei Zairong,Zhang Yanji,Wang Dali.Role of hypoxia and inflammation in wound healing[J].Chin J Burns Wounds,2024,40(6):1-7.DOI: 10.3760/cma.j.cn501225-20240111-00014.

缺氧与炎症在创面愈合中扮演的角色

doi: 10.3760/cma.j.cn501225-20240111-00014
基金项目: 

国家自然科学基金地区科学基金项目 82360445

省部共建协同创新中心项目 2020-39

遵义市科技计划项目 2021-3

贵州茅台医院科研与人才培养资金 2022-13

详细信息
    通讯作者:

    王达利,Email:daliwangzy@sina.com

Role of hypoxia and inflammation in wound healing

Funds: 

Regional Science Foundation Project of National Natural Science Foundation of China 82360445

Collaborative Innovation Center of Chinese Ministry of Education and Guizhou Province 2020-39

Talents Science Platform of Zunyi City 2021-3

Scientific Research and Talent Training Funds of Kweichow Moutai Hospital 2022-13

More Information
  • 摘要: 创面愈合是一个复杂的生物学过程,缺氧和炎症是启动创面愈合和影响创面愈合进程的2个关键因素。缺氧诱导因子1α(HIF-1α)和核因子κB是缺氧和炎症环境下的重要的调控因子,缺氧和炎症之间的相互作用本质上由HIF-1α和核因子κB信号通路所介导,二者失调导致的HIF-1α或核因子κB信号通路的异常表达均会影响创面微环境,导致创面异常愈合。该文讨论了缺氧和炎症对创面愈合的影响,强调了缺氧和炎症之间的相互协作对创面愈合的作用,以及二者失调对创面愈合质量的影响,并对目前缺氧和炎症信号通路的干预策略进行总结,同时对未来创面愈合的治疗进行展望。

     

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出版历程
  • 收稿日期:  2024-01-11
  • 网络出版日期:  2024-05-31

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