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协调组织修复:控制有害和修复性中性粒细胞功能的分子途径

贺伟峰 闫凌峰

贺伟峰, 闫凌峰. 协调组织修复:控制有害和修复性中性粒细胞功能的分子途径[J]. 中华烧伤与创面修复杂志, 2024, 40(5): 407-414. DOI: 10.3760/cma.j.cn501225-20240306-00089.
引用本文: 贺伟峰, 闫凌峰. 协调组织修复:控制有害和修复性中性粒细胞功能的分子途径[J]. 中华烧伤与创面修复杂志, 2024, 40(5): 407-414. DOI: 10.3760/cma.j.cn501225-20240306-00089.
He WF,Yan LF.Coordinating tissue repair: molecular pathways controlling the function of harmful and repairing neutrophils[J].Chin J Burns Wounds,2024,40(5):407-414.DOI: 10.3760/cma.j.cn501225-20240306-00089.
Citation: He WF,Yan LF.Coordinating tissue repair: molecular pathways controlling the function of harmful and repairing neutrophils[J].Chin J Burns Wounds,2024,40(5):407-414.DOI: 10.3760/cma.j.cn501225-20240306-00089.

协调组织修复:控制有害和修复性中性粒细胞功能的分子途径

doi: 10.3760/cma.j.cn501225-20240306-00089
基金项目: 

国家自然科学基金面上项目 31872742, 82172232

军队医学科技青年培育计划 20QNPY024

陆军军医大学科技创新能力提升专项 2019XQY12

详细信息
    通讯作者:

    贺伟峰,Email:whe761211@hotmail.com

Coordinating tissue repair: molecular pathways controlling the function of harmful and repairing neutrophils

Funds: 

General Program of National Natural Science Foundation of China 31872742, 82172232

Military Medical Science and Technology Youth Training Program 20QNPY024

Special Project for Enhancing Science and Technology Innovation Ability of Army Medical University 2019XQY12

More Information
  • 摘要: 中性粒细胞是最丰富的循环白细胞,作为损伤组织和感染部位的第一反应者,在愈合早期炎症反应中起着不可或缺的作用。中性粒细胞通过吞噬和破坏病原体、释放细胞毒性酶和代谢物以及传播炎症网络来提供即时宿主防御。然而,如果不加以控制,这些防御机制会造成重大的附带损害。专注于有害中性粒细胞炎症的诱因和免疫调节缺陷,并把握有害炎症的特定驱动因素,对重新校准炎症以促进内源性组织修复具有重要意义。该文从中性粒细胞炎症失衡的诱因出发,阐述中性粒细胞介导组织损伤的主要机制及相关病理表现,并强调了具有应用前景的治疗靶点。

     

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  • 收稿日期:  2024-03-06

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