Research advances on the application of fibroblasts and their derivatives in the treatment of diabetic foot ulcers
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摘要: 糖尿病足溃疡是糖尿病的严重并发症之一,具有易感染、难治愈、易复发等特点。目前,糖尿病足溃疡的治疗方法包括标准护理治疗、手术治疗、药物治疗等,但临床疗效欠佳。作为创面愈合关键细胞之一的成纤维细胞（Fb）,不仅可以通过分泌纤维连接蛋白、胶原蛋白构建角质形成细胞、上皮细胞等细胞迁移、增殖、定植的支架,还能通过分泌炎症因子、生长因子、细胞因子扭转糖尿病足溃疡慢性炎症局面,促进细胞增殖,改善创面微环境,是目前应用于糖尿病足溃疡创面治疗的细胞之一。该文从Fb角度出发,综述Fb及其衍生物在糖尿病足溃疡治疗中的应用情况,以期为糖尿病足溃疡的治疗提供参考。Abstract: Diabetic foot ulcer (DFU) is one of the serious complications of diabetes mellitus, which is characterized by susceptibility to infection, difficult to cure, and easy to relapse. At present, the treatment methods for DFUs include standard nursing care, surgical treatment, and medication, but the clinical efficacy is suboptimal. Fibroblasts (Fbs), as one of the key cells for wound healing, can not only secrete fibronectin and collagen to construct scaffolds for cell migration, proliferation, and colonization of keratinocytes and epithelial cells, but also secrete inflammatory factors, growth factors, and cytokines to reverse the chronic inflammation of DFUs, promote cell proliferation, and improve the wound microenvironment. It is one of the cell types currently used in DFU wound treatment. This article reviews the application of Fbs and their derivatives in DFU treatment from the perspective of Fbs, in order to provide a reference for DFU treatment.
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Key words:
- Diabetic foot /
- Foot ulcer /
- Fibroblasts /
- Exosomes /
- Skin, artificial /
- Wound repair
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参考文献
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图 1 成纤维细胞来源的外泌体改善高糖环境下血管内皮细胞功能的机制
注：Bcl-2为B淋巴细胞瘤-2,Bax为Bcl-2相关X蛋白,IL为白细胞介素,PCNA为增殖细胞核抗原,VEGF-A为血管内皮生长因子A；图中黑色竖线分隔左侧高糖环境下血管内皮细胞和右侧正常血管内皮细胞,横跨黑色竖线的圆弧形箭头表示左侧细胞向右侧细胞转化
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