线粒体动力学在糖尿病足溃疡中的作用机制及其相关干预策略研究进展

陕斌; 郭泽澳; 马学鹏; 井帅帅; 吴瑜; 潘海邦; 曾昭洋

doi:10.3760/cma.j.cn501225-20250304-00114

线粒体动力学在糖尿病足溃疡中的作用机制及其相关干预策略研究进展

doi: 10.3760/cma.j.cn501225-20250304-00114

1.
甘肃中医药大学附属医院关节外科,兰州　730000
2.
甘肃中医药大学中西医结合学院,兰州　730000

基金项目:

国家自然科学基金地区科学基金项目 82560950

甘肃省联合基金一般项目 24JRRA881

兰州市科技计划项目 2023-ZD-210

兰州市城关区科技计划项目 2022SHFZ0021

详细信息

通讯作者:
曾昭洋,Email：523645455@qq.com

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出版历程
- 收稿日期: 2025-03-04
- 网络出版日期: 2026-05-22

Research progress on the mechanism of mitochondrial dynamics in diabetic foot ulcers and its related intervention strategies

1.
Department of Joint Surgery, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
2.
School of Traditional Chinese and Western Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China

Funds:

Regional Science Fund program of National Natural Science Foundation of China 82560950

General Program of Gansu Provincial Joint Funds 24JRRA881

Lanzhou Science and Technology Plan Project 2023-ZD-210

Science and Technology Plan Project of Chengguan District of Lanzhou City 2022SHFZ0021

More Information

Corresponding author: Zeng Zhaoyang, Email: 523645455@qq.com

摘要

摘要: 糖尿病足溃疡（DFU）是糖尿病患者常见且严重的慢性并发症,具有高复发率、致残和致死风险,给个人健康与社会医疗系统带来沉重负担。线粒体动力学指线粒体通过分裂与融合的动态平衡维持细胞的能量代谢和稳态,而在糖尿病病理环境中,高血糖和氧化应激会破坏这一平衡,导致线粒体功能紊乱,进一步加剧DFU的炎症反应和组织损伤。近年来,靶向线粒体动力学的干预策略被认为是改善DFU症状、促进创面愈合的潜在治疗手段。该文基于国内外最新研究,综述DFU中线粒体动力学的研究进展,重点探讨其在DFU病理过程中的核心作用机制及调控因素,并总结当前主要的干预策略。通过系统分析,该文旨在加深对DFU相关线粒体动力学机制的理解,为临床提供新的靶向治疗思路。
- 糖尿病足 /
- 溃疡 /
- 线粒体动力学 /
- 线粒体分裂与融合 /
- 创面修复
Abstract: Diabetic foot ulcer (DFU) is a common and serious chronic complication in patients with diabetes, characterized by high recurrence rates, risks of disability and mortality, which imposes a heavy burden on individual health and the social healthcare system. Mitochondrial dynamics refer to the dynamic balance between mitochondrial fission and fusion that maintains cellular energy metabolism and homeostasis. However, in the pathological environment of diabetes, hyperglycemia and oxidative stress disrupt this balance, leading to mitochondrial dysfunction and further exacerbating the inflammatory response and tissue damage in DFU. In recent years, intervention strategies targeting mitochondrial dynamics have been considered a potential therapeutic approach to alleviate DFU symptoms and promote wound healing. Based on the latest domestic and international research, this article reviews the progress of research on mitochondrial dynamics in DFU, with a focus on exploring its core mechanisms and regulatory factors in the pathological process of DFU, and summarizes the current main intervention strategies. Through systematic analysis, this article aims to deepen the understanding of the mechanisms underlying mitochondrial dynamics in DFU and to provide new ideas for targeted therapy in clinical practice.
- Diabetic foot /
- Ulcer /
- Mitochondrial dynamics /
- Mitochondrial fission and fusion /
- Wound repair
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参考文献(67)

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