留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

以慢性危重症的理念管理老年难愈性创面

郭光华 黄圣宇 朱峰

郭光华, 黄圣宇, 朱峰. 以慢性危重症的理念管理老年难愈性创面[J]. 中华烧伤与创面修复杂志, 2025, 41(8): 734-739. DOI: 10.3760/cma.j.cn501225-20250314-00130.
引用本文: 郭光华, 黄圣宇, 朱峰. 以慢性危重症的理念管理老年难愈性创面[J]. 中华烧伤与创面修复杂志, 2025, 41(8): 734-739. DOI: 10.3760/cma.j.cn501225-20250314-00130.
Guo GH,Huang SY,Zhu F.Managing refractory wounds in the elderly with the concept of chronic critical illness[J].Chin J Burns Wounds,2025,41(8):734-739.DOI: 10.3760/cma.j.cn501225-20250314-00130.
Citation: Guo GH,Huang SY,Zhu F.Managing refractory wounds in the elderly with the concept of chronic critical illness[J].Chin J Burns Wounds,2025,41(8):734-739.DOI: 10.3760/cma.j.cn501225-20250314-00130.

以慢性危重症的理念管理老年难愈性创面

doi: 10.3760/cma.j.cn501225-20250314-00130
基金项目: 

国家自然科学基金地区科学基金项目 82160376, 81960352

江西省科技厅重点研发计划重点项目 20171ACG70004

详细信息
    通讯作者:

    郭光华,Email:guogh2000@hotmail.com

Managing refractory wounds in the elderly with the concept of chronic critical illness

Funds: 

Regional Science Foundation Project of National Natural Science Foundation of China 82160376, 81960352

Key Program for Key Research and Development Program of Science and Technology Department of Jiangxi Province of China 20171ACG70004

More Information
  • 摘要: 老年人皮肤结构发生改变,皮肤软组织容易受到损伤,从而导致难愈性创面形成的风险增加。老年患者具有特殊的病理生理特征,多伴随严重、复杂的共病(脏器疾病、精神心理问题、老年综合征等)和多药治疗状态,有的患者已长期处于慢性危重症状态。高龄、难愈性创面和危重病在临床中常相互影响,形成恶性循环。老年患者的难愈性创面管理,应视为老年共病管理的重要一环。为此,笔者提出将慢性危重症的理念引入老年难愈性创面管理,通过多学科、动态、分层关注共病和多药治疗状态之间的相互影响,在聚焦老年难愈性创面诊断和治疗的同时,兼顾老年脏器疾病的诊断和治疗、功能维护和实际需求。

     

  • 参考文献(43)

    [1] GirardK, RaffinTA. The chronically critically ill: to save or let die?[J]. Respir Care, 1985,30(5):339-347.
    [2] ParfenovAL, RazzhivinVP, PetrovaMV. Chronic critical illness: current aspects of the problem (review)[J]. Sovrem Tekhnologii Med, 2022, 14(3): 70-81. DOI: 10.17691/stm2022.14.3.08.
    [3] MarchioniA, FantiniR, AntenoraF, et al. Chronic critical illness: the price of survival[J]. Eur J Clin Invest, 2015,45(12):1341-1349. DOI: 10.1111/eci.12547.
    [4] LiY, ZhuL. Effect of perioperative benzodiazepine use on intraoperative awareness and postoperative delirium. Comment on Br J Anaesth 2023; 131: 302-13[J]. Br J Anaesth, 2023,131(6):e201-e202. DOI: 10.1016/j.bja.2023.09.012.
    [5] BattJ, dos SantosCC, CameronJI, et al. Intensive care unit-acquired weakness: clinical phenotypes and molecular mechanisms[J]. Am J Respir Crit Care Med, 2013,187(3):238-246. DOI: 10.1164/rccm.201205-0954SO.
    [6] GentileLF, CuencaAG, EfronPA, et al. Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care[J]. J Trauma Acute Care Surg, 2012,72(6):1491-1501. DOI: 10.1097/TA.0b013e318256e000.
    [7] EfronPA, BrakenridgeSC, MohrAM, et al. The persistent inflammation, immunosuppression, and catabolism syndrome 10 years later[J]. J Trauma Acute Care Surg, 2023,95(5):790-799. DOI: 10.1097/TA.0000000000004087.
    [8] HoriguchiH, LoftusTJ, HawkinsRB, et al. Innate immunity in the persistent inflammation, immunosuppression, and catabolism syndrome and its implications for therapy[J]. Front Immunol, 2018, 9: 595. DOI: 10.3389/fimmu.2018.00595.
    [9] VanzantEL, LopezCM, Ozrazgat-BaslantiT, et al. Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma[J]. J Trauma Acute Care Surg, 2014,76(1):21-29; discussion 29-30. DOI: 10.1097/TA.0b013e3182ab1ab5.
    [10] 丁仁彧, 马晓春. 持续炎性反应-免疫抑制-分解代谢综合征:一种特殊类型的慢重症[J]. 中华胃肠外科杂志, 2016, 19(7): 734-736. DOI: 10.3760/cma.j.issn.1671-0274.2016.07.003.
    [11] VoiriotG, OualhaM, PierreA, et al. Chronic critical illness and post-intensive care syndrome: from pathophysiology to clinical challenges[J]. Ann Intensive Care, 2022,12(1):58. DOI: 10.1186/s13613-022-01038-0.
    [12] NomelliniV, KaplanLJ, SimsCA, et al. Chronic critical illness and persistent inflammation: what can we learn from the elderly, injured, septic, and malnourished?[J]. Shock, 2018,49(1):4-14. DOI: 10.1097/SHK.0000000000000939.
    [13] KandilovAIngberMMorleyMet alChronically critically ill population payment recommendations (CCIPPR)2014

    KandilovA, IngberM, MorleyM, et al. Chronically critically ill population payment recommendations (CCIPPR)[Z]. 2014.

    [14] MaguireJM, CarsonSS. Strategies to combat chronic critical illness[J]. Curr Opin Crit Care, 2013,19(5):480-487. DOI: 10.1097/MCC.0b013e328364d65e.
    [15] 杨娜, 李维勤. 慢重症新诊断标准及治疗进展[J/CD].中华危重症医学杂志(电子版),2016,9(3):197-200. DOI: 10.3877/cma.j.issn.1674-6880.2016.03.012.
    [16] NelsonJE, HopeAA. Integration of palliative care in chronic critical illness management[J]. Respir Care, 2012,57(6):1004-1012; discussion 1012-1013. DOI: 10.4187/respcare.01624.
    [17] 王玲玲, 陈蕊, 董家辉, 等. 慢重症患者的营养支持策略[J]. 中华危重病急救医学, 2021, 33(3): 381-384. DOI: 10.3760/cma.j.cn121430-20201010-00665.
    [18] RaziyevaK, KimY, ZharkinbekovZ, et al. Immunology of acute and chronic wound healing[J]. Biomolecules, 2021, 11(5):700. DOI: 10.3390/biom11050700.
    [19] BlairMJ, JonesJD, WoessnerAE, et al. Skin structure-function relationships and the wound healing response to intrinsic aging[J]. Adv Wound Care (New Rochelle), 2020, 9(3): 127-143. DOI: 10.1089/wound.2019.1021.
    [20] 郭光华. 中国南部某主要烧伤中心慢性难愈性创面住院患者流行病学特征分析[J/CD]. 中华损伤与修复杂志(电子版), 2022, 17(2): 184. DOI: 10.3877/cma.j.issn.1673-9450.2022.02.019.
    [21] MartinengoL, OlssonM, BajpaiR, et al. Prevalence of chronic wounds in the general population: systematic review and meta-analysis of observational studies[J]. Ann Epidemiol, 2019,29:8-15. DOI: 10.1016/j.annepidem.2018.10.005.
    [22] GouldL, AbadirP, BremH, et al. Chronic wound repair and healing in older adults: current status and future research[J]. Wound Repair Regen, 2015,23(1):1-13. DOI: 10.1111/wrr.12245.
    [23] FarageMA, MillerKW, ElsnerP, et al. Intrinsic and extrinsic factors in skin ageing: a review[J]. Int J Cosmet Sci, 2008,30(2):87-95. DOI: 10.1111/j.1468-2494.2007.00415.x.
    [24] GreenhalghDG. Skin, soft tissue, and wound healing in the elderly[M]//Luchette FA, Yelon JA. Geriatric trauma and critical care. Cham: Springer International Publishing, 2017.
    [25] MiraJC, CuschieriJ, Ozrazgat-BaslantiT, et al. The epidemiology of chronic critical illness after severe traumatic injury at two level-one trauma centers[J]. Crit Care Med, 2017,45(12):1989-1996. DOI: 10.1097/CCM.0000000000002697.
    [26] WuYK, ChengNC, ChengCM. Biofilms in chronic wounds: pathogenesis and diagnosis[J]. Trends Biotechnol, 2019, 37(5): 505-517. DOI: 10.1016/j.tibtech.2018.10.011.
    [27] NierenbergNE, LevineJM. Infectious aspects of chronic wounds[J]. Clin Geriatr Med, 2024, 40(3): 471-480. DOI: 10.1016/j.cger.2024.03.001.
    [28] DiPietroLA, WilgusTA, KohTJ. Macrophages in healing wounds: paradoxes and paradigms[J]. Int J Mol Sci, 2021, 22(2):950. DOI: 10.3390/ijms22020950.
    [29] YangS, GuZ, LuC, et al. Neutrophil extracellular traps are markers of wound healing impairment in patients with diabetic foot ulcers treated in a multidisciplinary setting[J]. Adv Wound Care (New Rochelle), 2020, 9(1): 16-27. DOI: 10.1089/wound.2019.0943.
    [30] EmingSA, KriegT, DavidsonJM. Inflammation in wound repair: molecular and cellular mechanisms[J]. J Invest Dermatol, 2007,127(3):514-525. DOI: 10.1038/sj.jid.5700701.
    [31] WilkinsonHN, HardmanMJ. Wound healing: cellular mechanisms and pathological outcomes[J]. Open Biol, 2020,10(9):200223. DOI: 10.1098/rsob.200223.
    [32] CasaerMP, ZieglerTR. Nutritional support in critical illness and recovery[J]. Lancet Diabetes Endocrinol, 2015,3(9):734-745. DOI: 10.1016/S2213-8587(15)00222-3.
    [33] GouldLJ, AlderdenJ, AslamR, et al. WHS guidelines for the treatment of pressure ulcers-2023 update[J]. Wound Repair Regen, 2024,32(1):6-33. DOI: 10.1111/wrr.13130.
    [34] MunozN. Pressure injuries among critical care patients[J]. Crit Care Nurs Clin North Am, 2020, 32(4): 573-587. DOI: 10.1016/j.cnc.2020.08.007.
    [35] VeličkovićVM, SpelmanT, ClarkM, et al. Individualized risk prediction for improved chronic wound management[J]. Adv Wound Care (New Rochelle), 2023, 12(7): 387-398. DOI: 10.1089/wound.2022.0017.
    [36] JaisS, PratamaK. A diabetic foot wound healing assessment tool: a scoping review[J]. Heliyon, 2023, 9(5): e15736. DOI: 10.1016/j.heliyon.2023.e15736.
    [37] SciclunaBP, van VughtLA, ZwindermanAH, et al. Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study[J]. Lancet Respir Med, 2017,5(10):816-826. DOI: 10.1016/S2213-2600(17)30294-1.
    [38] van AmstelRBE, KennedyJN, SciclunaBP, et al. Uncovering heterogeneity in sepsis: a comparative analysis of subphenotypes[J]. Intensive Care Med, 2023, 49(11): 1360-1369. DOI: 10.1007/s00134-023-07239-w.
    [39] Reifs JiménezD, Casanova-LozanoL, Grau-CarriónS, et al. Artificial intelligence methods for diagnostic and decision-making assistance in chronic wounds: a systematic review[J]. J Med Syst, 2025, 49(1): 29. DOI: 10.1007/s10916-025-02153-8.
    [40] WuY, WuL, YuM. The clinical value of intelligent wound measurement devices in patients with chronic wounds: a scoping review[J]. Int Wound J, 2024, 21(3): e14843. DOI: 10.1111/iwj.14843.
    [41] SarpS, KuzluM, ZhaoY, et al. Digital twin in healthcare: a study for chronic wound management[J]. IEEE J Biomed Health Inform, 2023, 27(11): 5634-5643. DOI: 10.1109/JBHI.2023.3299028.
    [42] YangJ, LiuC, SunH, et al. The progress in titanium alloys used as biomedical implants: from the view of reactive oxygen species[J]. Front Bioeng Biotechnol, 2022,10:1092916. DOI: 10.3389/fbioe.2022.1092916.
    [43] 海峡两岸医药卫生交流协会烧创伤暨组织修复专委会. 负压伤口疗法在糖尿病足创面治疗中的应用全国专家共识(2021版)[J]. 中华烧伤杂志, 2021, 37(6): 508-518. DOI: 10.3760/cma.j.cn501120-20210107-00010.
  • 加载中
图(1)
计量
  • 文章访问数:  2217
  • HTML全文浏览量:  24
  • PDF下载量:  41
  • 被引次数: 0
出版历程
  • 收稿日期:  2025-03-14

目录

    /

    返回文章
    返回