Expert consensus on prevention and management of orthopedic surgical site infection wounds (2026 edition)
-
摘要: 骨科手术部位感染(SSI)是骨科术后的重要并发症,其发生率因具体手术类型不同而存在差异,通常为0.4%~16.1%,在高危病例中甚至超过50%。当骨科SSI发展到需要干预的阶段,即表现为切口裂开、组织坏死或内植入物外露时,不仅会显著延长恢复期,还会加重医疗负担。目前国内外均缺乏针对此类创面的标准化的预防和管理方案,导致临床实践存在较大差异。为提高骨科患者术后安全性,降低骨科SSI创面的发生率,提升该类创面的诊断与治疗质量,中国医师协会创面修复专业委员会组织多学科专家制订了该共识。该共识涵盖多个主题,包括骨科SSI创面的预防策略、临床表现、诊断评估、创面处理与修复、功能重建及康复治疗,旨在为此类创面的预防与治疗提供全面参考。Abstract: Orthopedic surgical site infection (SSI) represents a major complication post-orthopedic surgery, with incidence rates differing based on the specific procedure, typically ranging from 0.4% to 16.1%, and potentially exceeding 50% in high-risk scenarios. When orthopedic SSI advances to a stage necessitating intervention—characterized by wound dehiscence, tissue necrosis, or exposed implants—it not only substantially extends the recovery duration but also escalates the healthcare burden. Presently, there is an absence of standardized prevention and management protocols for such wounds both nationally and internationally, resulting in significant variability in clinical practice. In order to augment postoperative safety for orthopedic patients, diminish the incidence of orthopedic SSI wounds, and enhance the quality of diagnosis and treatment for these wounds, the Wound Repair Professional Committee of Chinese Medical Doctor Association has convened a multidisciplinary panel of experts to formulate this consensus. This consensus encompasses a range of topics, including prevention strategies, clinical manifestations, diagnostic evaluation, wound management and repair, functional reconstruction, and rehabilitation therapy for orthopedic SSI wounds. The objective is to furnish a comprehensive reference for the prevention and treatment of these wounds.
-
Key words:
- Surgical wound infection /
- Therapy /
- Orthopedics /
- Infected wounds /
- Preventive measures /
- Wound repair /
- Expert consensus
-
参考文献
(152) [1] RenY,LiuL,SunD,et al.Epidemiological updates of post-traumatic related limb osteomyelitis in China: a 10 years multicentre cohort study[J].Int J Surg,2023,109(9):2721-2731.DOI: 10.1097/JS9.0000000000000502. [2] LerouxT,WassersteinD,HenryP,et al.Rate of and risk factors for reoperations after open reduction and internal fixation of midshaft clavicle fractures: a population-based study in Ontario, Canada[J].J Bone Joint Surg Am,2014,96(13):1119-1125.DOI: 10.2106/JBJS.M.00607. [3] PatzakisMJ,WilkinsJ.Factors influencing infection rate in open fracture wounds[J].Clin Orthop Relat Res,1989(243):36-40. [4] 白求恩公益基金会,中国康复技术转化及发展促进会,中国研究型医院学会,等.骨科择期手术加速康复预防手术部位感染指南[J].中华骨与关节外科杂志,2020,13(1):1-7. DOI: 10.3969/j.issn.2095-9958.2020.01.01. [5] WiseBT,ConnellyD,RoccaM,et al.A predictive score for determining risk of surgical site infection after orthopaedic trauma surgery[J].J Orthop Trauma,2019,33(10):506-513.DOI: 10.1097/BOT.0000000000001513. [6] MetsemakersWJ,KuehlR,MoriartyTF,et al.Infection after fracture fixation: current surgical and microbiological concepts[J].Injury,2018,49(3):511-522.DOI: 10.1016/j.injury.2016.09.019. [7] 沈余明.手术部位感染及其引发创面的防治策略[J].中华烧伤杂志,2021,37(3):207-212.DOI: 10.3760/cma.j.cn501120-20210105-00006. [8] 中华医学会骨科学分会创伤骨科学组,中华医学会骨科学分会外固定与肢体重建学组,中国医师协会创伤外科医师分会创伤感染专家委员会,等.中国骨折内固定术后感染诊断与治疗专家共识(2018版)[J].中华创伤骨科杂志,2018,20(11):929-936.DOI: 10.3760/cma.j.issn.1671-7600.2018.11.002. [9] TaherpourN,MehrabiY,SeifiA,et al.Epidemiologic characteristics of orthopedic surgical site infections and under-reporting estimation of registries using capture-recapture analysis[J].BMC Infect Dis,2021,21(1):3.DOI: 10.1186/s12879-020-05687-z. [10] TsaiY,ChangCH,LinYC,et al.Different microbiological profiles between hip and knee prosthetic joint infections[J].J Orthop Surg (Hong Kong),2019,27(2):2309499019847768.DOI: 10.1177/2309499019847768. [11] ZhangY,WangQ,YinY,et al.Epidemiology of carbapenem-resistant enterobacteriaceae infections: report from the China CRE Network[J].Antimicrob Agents Chemother,2018,62(2):e01882-17.DOI: 10.1128/AAC.01882-17. [12] van DuinD,AriasCA,KomarowL,et al.Molecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2): a prospective cohort study[J].Lancet Infect Dis,2020,20(6):731-741.DOI: 10.1016/S1473-3099(19)30755-8. [13] 国家卫生健康委加速康复外科专家委员会骨科专家组,中国研究型医院学会骨科加速康复专业委员会,中国康复技术转化及促进会骨科加速康复专业委员会.骨科加速康复手术切口操作与并发症防治专家共识[J].中华骨与关节外科杂志,2022,15(10):776-784.DOI: 10.3969/j.issn.2095-9958.2022.10.09. [14] WebsterJ,OsborneS.Preoperative bathing or showering with skin antiseptics to prevent surgical site infection[J].Cochrane Database Syst Rev,2015,2015(2):CD004985.DOI: 10.1002/14651858.CD004985.pub5. [15] LynchW,DaveyPG,MalekM,et al.Cost-effectiveness analysis of the use of chlorhexidine detergent in preoperative whole-body disinfection in wound infection prophylaxis[J].J Hosp Infect,1992,21(3):179-191.DOI: 10.1016/0195-6701(92)90074-v. [16] LefebvreA,SaliouP,LucetJC,et al.Preoperative hair removal and surgical site infections: network meta-analysis of randomized controlled trials[J].J Hosp Infect,2015,91(2):100-108.DOI: 10.1016/j.jhin.2015.06.020. [17] KowalskiTJ,KothariSN,MathiasonMA,et al.Impact of hair removal on surgical site infection rates: a prospective randomized noninferiority trial[J].J Am Coll Surg,2016,223(5):704-711.DOI: 10.1016/j.jamcollsurg.2016.03.032. [18] 茅一萍,郑军,李雷,等.术前去除毛发原则中国专家共识[J].中华医院感染学杂志,2025,35(10):1441-1449.DOI: 10.11816/cn.ni.2025-250002. [19] MellingAC,AliB,ScottEM,et al.Effects of preoperative warming on the incidence of wound infection after clean surgery: a randomised controlled trial[J].Lancet,2001,358(9285):876-880.DOI: 10.1016/S0140-6736(01)06071-8. [20] KurzA,SesslerDI,LenhardtR.Perioperative normothermia to reduce the incidence of surgical-wound infection and shorten hospitalization. Study of Wound Infection and Temperature Group[J].N Engl J Med,1996,334(19):1209-1215.DOI: 10.1056/NEJM199605093341901. [21] OstranderRV,BotteMJ,BrageME.Efficacy of surgical preparation solutions in foot and ankle surgery[J].J Bone Joint Surg Am,2005,87(5):980-985.DOI: 10.2106/JBJS.D.01977. [22] SavageJW,WeatherfordBM,SugruePA,et al.Efficacy of surgical preparation solutions in lumbar spine surgery[J].J Bone Joint Surg Am,2012,94(6):490-494.DOI: 10.2106/JBJS.K.00471. [23] TorresKA,KonradeE,WhiteJ,et al.Irrigation techniques used in spine surgery for surgical site infection prophylaxis: a systematic review and meta-analysis[J].BMC Musculoskelet Disord,2022,23(1):813.DOI: 10.1186/s12891-022-05763-2. [24] Carballo CuelloCM,Fernández-de ThomasRJ,De JesusO,et al.Prevention of surgical site infection in lumbar instrumented fusion using a sterile povidone-iodine solution[J].World Neurosurg,2021,151:e700-e706.DOI: 10.1016/j.wneu.2021.04.094. [25] MalletC,MeissburgerV,CaserisM,et al.Does the use of intrawound povidone-iodine irrigation and local vancomycin powder impact surgical site infection rate in adolescent idiopathic scoliosis surgery?[J].Eur Spine J,2022,31(11):3020-3028.DOI: 10.1007/s00586-022-07340-6. [26] 耐甲氧西林金黄色葡萄球菌感染防治专家委员会.耐甲氧西林金黄色葡萄球菌感染防治专家共识2011年更新版[J/OL].中华实验和临床感染病杂志(电子版),2011,5(3):372-384[2025-05-15].https://d.wanfangdata.com.cn/periodical/CiBQZXJpb2RpY2FsQ0hJU29scjkyMDI1MTExNzE2MDExNxIVemhzeWhsY2dyYnp6MjAxMTAzMDIwGgh3dXZ5c3R5Nw%3D%3D.DOI: 10.3877/cma.j.issn.1674-1358.2011.03.020. [27] MackiM,HamiltonT,LimS,et al.The role of postoperative antibiotic duration on surgical site infection after lumbar surgery[J].J Neurosurg Spine,2022,36(2):254-260.DOI: 10.3171/2021.4.SPINE201839. [28] 陆蕾,黄明芬,高玲花.骨科外来手术器械清洗质量观察[J].中华医院感染学杂志,2012,22(17):3805-3806,3796. [29] 任燕,陈辉,杨琳,等.外来手术器械不同清洗方法的清洗效果探讨[J].中华医院感染学杂志,2017,27(21):5034-5036.DOI: 10.11816/cn.ni.2017-170902. [30] LaineT,AarnioP.Glove perforation in orthopaedic and trauma surgery. A comparison between single, double indicator gloving and double gloving with two regular gloves[J].J Bone Joint Surg Br,2004,86(6):898-900.DOI: 10.1302/0301-620x.86b6.14821. [31] de BarrosM,GodoiT,Ferretti FilhoM,et al.Surgical gloves in orthopedic trauma procedures: how many lose their integrity?[J].Rev Bras Ortop (Sao Paulo),2021,56(3):379-383.DOI: 10.1055/s-0040-1722591. [32] TannerJ,ParkinsonH.Double gloving to reduce surgical cross-infection[J].Cochrane Database Syst Rev,2006,2006(3):CD003087.DOI: 10.1002/14651858.CD003087.pub2. [33] LeeJY,YunSH,KangJW,et al.Bacterial contamination of surgical gloves during clean orthopedic surgery[J].Infect Control Hosp Epidemiol,2024,45(8):991-993.DOI: 10.1017/ice.2024.49. [34] SrWWG,CooperJM,LippertD,et al.Glove and gown effects on intraoperative bacterial contamination[J].Ann Surg,2014,259(3):591-597.DOI: 10.1097/SLA.0b013e3182a6f2d9. [35] CarterAH,CasperDS,ParviziJ,et al.A prospective analysis of glove perforation in primary and revision total hip and total knee arthroplasty[J].J Arthroplasty,2012,27(7):1271-1275.DOI: 10.1016/j.arth.2012.01.021. [36] BoekelP,EkET.Contamination associated with glove changing techniques in the operating theatre[J].Front Surg,2022,9:839040.DOI: 10.3389/fsurg.2022.839040. [37] 国家卫生健康委加速康复外科专家委员会骨科专家组,中国研究型医院学会骨科加速康复专业委员会,中国康复技术转化及促进会骨科加速康复专业委员会.骨科择期手术加速康复预防手术部位感染专家共识[J].中华骨与关节外科杂志,2022,15(10):746-753.DOI: 10.3969/j.issn.2095-9958.2022.10.05. [38] 中华医学会外科学分会外科感染与重症医学学组,中国医师协会外科医师分会肠瘘外科医师专业委员会.中国手术部位感染预防指南[J].中华胃肠外科杂志,2019,22(4):301-314.DOI: 10.3760/cma.j.issn.1671-0274.2019.04.001. [39] LiangZ,RongK,GuW,et al.Surgical site infection following elective orthopaedic surgeries in geriatric patients: incidence and associated risk factors[J].Int Wound J,2019,16(3):773-780.DOI: 10.1111/iwj.13096. [40] de VriesFE,GansSL,SolomkinJS,et al.Meta-analysis of lower perioperative blood glucose target levels for reduction of surgical-site infection[J].Br J Surg,2017,104(2):e95-e105.DOI: 10.1002/bjs.10424. [41] WangWH,HsiehTC,WuWT,et al.Correlation between the control of blood glucose level and HbA1C and the incidence of surgical site infection after emergent surgery for the lower limb fracture among type II DM patients aged more than 50 years old[J].J Clin Med,2022,11(19):5552.DOI: 10.3390/jcm11195552. [42] Hijas-GómezAI,Checa-GarcíaA,López-HualdaÁ,et al.Surgical site infection in hip arthroplasty in a 10-year follow-up prospective study: risk and factors associated[J].Am J Infect Control,2020,48(12):1437-1444.DOI: 10.1016/j.ajic.2020.05.021. [43] LeboNL,QuimbyAE,CaulleyL,et al.Surgical site infection affects length of stay after complex head and neck procedures[J].Laryngoscope,2020,130(12):E837-E842.DOI: 10.1002/lary.28512. [44] KimES,KimHB,SongKH,et al.Prospective nationwide surveillance of surgical site infections after gastric surgery and risk factor analysis in the Korean Nosocomial Infections Surveillance System (KONIS)[J].Infect Control Hosp Epidemiol,2012,33(6):572-580.DOI: 10.1086/665728. [45] TuuliMG,LiuJ,TitaA,et al.Effect of prophylactic negative pressure wound therapy vs standard wound dressing on surgical-site infection in obese women after cesarean delivery: a randomized clinical trial[J].JAMA,2020,324(12):1180-1189.DOI: 10.1001/jama.2020.13361. [46] CostaML,AchtenJ,KnightR,et al.Effect of incisional negative pressure wound therapy vs standard wound dressing on deep surgical site infection after surgery for lower limb fractures associated with major trauma: the WHIST randomized clinical trial[J].JAMA,2020,323(6):519-526.DOI: 10.1001/jama.2020.0059. [47] JavedAA,TeinorJ,WrightM,et al.Negative pressure wound therapy for surgical-site infections: a randomized trial[J].Ann Surg,2019,269(6):1034-1040.DOI: 10.1097/SLA.0000000000003056. [48] Berríos-TorresSI,UmscheidCA,BratzlerDW,et al.Centers for disease control and prevention guideline for the prevention of surgical site infection, 2017[J].JAMA Surg,2017,152(8):784-791.DOI: 10.1001/jamasurg.2017.0904. [49] WilsonAP,TreasureT,SturridgeMF,et al.A scoring method (ASEPSIS) for postoperative wound infections for use in clinical trials of antibiotic prophylaxis[J].Lancet,1986,1(8476):311-313.DOI: 10.1016/s0140-6736(86)90838-x. [50] BruceJ,RussellEM,MollisonJ,et al.The quality of measurement of surgical wound infection as the basis for monitoring: a systematic review[J].J Hosp Infect,2001,49(2):99-108.DOI: 10.1053/jhin.2001.1045. [51] PeelAL,TaylorEW.Proposed definitions for the audit of postoperative infection: a discussion paper. Surgical Infection Study Group[J].Ann R Coll Surg Engl,1991,73(6):385-388. [52] MetsemakersWJ,MorgensternM,McNallyMA,et al.Fracture-related infection: a consensus on definition from an international expert group[J].Injury,2018,49(3):505-510.DOI: 10.1016/j.injury.2017.08.040. [53] SchwotzerN,WahlP,FracheboudD,et al.Optimal culture incubation time in orthopedic device-associated infections: a retrospective analysis of prolonged 14-day incubation[J].J Clin Microbiol,2014,52(1):61-66.DOI: 10.1128/JCM.01766-13. [54] SchäferP,FinkB,SandowD,et al.Prolonged bacterial culture to identify late periprosthetic joint infection: a promising strategy[J].Clin Infect Dis,2008,47(11):1403-1409.DOI: 10.1086/592973. [55] CopanitsanouP.Recognising and preventing surgical site infection after orthopaedic surgery[J].Int J Orthop Trauma Nurs,2020,37:100751.DOI: 10.1016/j.ijotn.2019.100751. [56] DragoL,ClericiP,MorelliI,et al.The World Association against Infection in Orthopaedics and Trauma (WAIOT) procedures for microbiological sampling and processing for periprosthetic joint infections (PJIs) and other implant-related infections[J].J Clin Med,2019,8(7):933.DOI: 10.3390/jcm8070933. [57] OnseaJ,DepypereM,GovaertG,et al.Accuracy of tissue and sonication fluid sampling for the diagnosis of fracture-related infection: a systematic review and critical appraisal[J].J Bone Jt Infect,2018,3(4):173-181.DOI: 10.7150/jbji.27840. [58] MoriartyTF,MetsemakersWJ,MorgensternM,et al.Fracture-related infection[J].Nat Rev Dis Primers,2022,8(1):67.DOI: 10.1038/s41572-022-00396-0. [59] HongHL,FlurinL,ThoendelMJ,et al.Targeted versus shotgun metagenomic sequencing-based detection of microorganisms in sonicate fluid for periprosthetic joint infection diagnosis[J].Clin Infect Dis,2023,76(3):e1456-e1462.DOI: 10.1093/cid/ciac646. [60] HuH,DingH,LyuJ,et al.Detection of rare microorganisms in bone and joint infections by metagenomic next-generation sequencing[J].Bone Joint Res,2024,13(8):401-410.DOI: 10.1302/2046-3758.138.BJR-2023-0420.R1. [61] HaoL,WenP,SongW,et al.Direct detection and identification of periprosthetic joint infection pathogens by metagenomic next-generation sequencing[J].Sci Rep,2023,13(1):7897.DOI: 10.1038/s41598-023-35215-3. [62] GuptonM,BurnsJ.Metagenomic next-generation sequencing in osteoarticular infections with a focus on pediatrics: current concepts and clinical applications[J].EFORT Open Rev,2023,8(4):199-212.DOI: 10.1530/EOR-22-0136. [63] WangG,LongJ,ZhuangY,et al.Application of metagenomic next-generation sequencing in the detection of pathogens in spinal infections[J].Spine J,2023,23(6):859-867.DOI: 10.1016/j.spinee.2023.02.001. [64] MookWR,GarriguesGE.Diagnosis and management of periprosthetic shoulder infections[J].J Bone Joint Surg Am,2014,96(11):956-965.DOI: 10.2106/JBJS.M.00402. [65] AnHS,SeldomridgeJA.Spinal infections: diagnostic tests and imaging studies[J].Clin Orthop Relat Res,2006,444:27-33.DOI: 10.1097/01.blo.0000203452.36522.97. [66] SaeedK,AhmadN,DrydenM.The value of procalcitonin measurement in localized skin and skin structure infection, diabetic foot infections, septic arthritis and osteomyelitis[J].Expert Rev Mol Diagn,2014,14(1):47-54.DOI: 10.1586/14737159.2014.864238. [67] HuX,ChenJ,ZhengX,et al.Establishment and application of TSDPSO-SVM model combined with multi-dimensional feature fusion method in the identification of fracture-related infection[J].Sci Rep,2023,13(1):19632.DOI: 10.1038/s41598-023-46526-w. [68] GovaertGA,IJpmaFF,McNallyM,et al.Accuracy of diagnostic imaging modalities for peripheral post-traumatic osteomyelitis - a systematic review of the recent literature[J].Eur J Nucl Med Mol Imaging,2017,44(8):1393-1407.DOI: 10.1007/s00259-017-3683-7. [69] CytevalC,BourdonA.Imaging orthopedic implant infections[J].Diagn Interv Imaging,2012,93(6):547-557.DOI: 10.1016/j.diii.2012.03.004. [70] WenterV,MüllerJP,AlbertNL,et al.The diagnostic value of [(18)F]FDG PET for the detection of chronic osteomyelitis and implant-associated infection[J].Eur J Nucl Med Mol Imaging,2016,43(4):749-761.DOI: 10.1007/s00259-015-3221-4. [71] BrownTL,SpencerHJ,BeenkenKE,et al.Evaluation of dynamic [18F]-FDG-PET imaging for the detection of acute post-surgical bone infection[J].PLoS One,2012,7(7):e41863.DOI: 10.1371/journal.pone.0041863. [72] PatzakisMJ,ZalavrasCG.Chronic posttraumatic osteomyelitis and infected nonunion of the tibia: current management concepts[J].J Am Acad Orthop Surg,2005,13(6):417-427.DOI: 10.5435/00124635-200510000-00006. [73] OchsnerPE,HailemariamS.Histology of osteosynthesis associated bone infection[J].Injury,2006,37Suppl 2:S49-58.DOI: 10.1016/j.injury.2006.04.009. [74] MastersEA,RicciardiBF,BentleyK,et al.Skeletal infections: microbial pathogenesis, immunity and clinical management[J].Nat Rev Microbiol,2022,20(7):385-400.DOI: 10.1038/s41579-022-00686-0. [75] DudarevaM,HotchenAJ,FergusonJ,et al.The microbiology of chronic osteomyelitis: changes over ten years[J].J Infect,2019,79(3):189-198.DOI: 10.1016/j.jinf.2019.07.006. [76] WalterN,BaertlS,EngelstaedterU,et al.Letter in response to article in journal of infection: "The microbiology of chronic osteomyelitis: Changes over ten years"[J].J Infect,2021,83(6):709-737.DOI: 10.1016/j.jinf.2021.09.006. [77] CalhounJH,ManringMM,ShirtliffM.Osteomyelitis of the long bones[J].Semin Plast Surg,2009,23(2):59-72.DOI: 10.1055/s-0029-1214158. [78] RaoN,ZiranBH,LipskyBA.Treating osteomyelitis: antibiotics and surgery[J].Plast Reconstr Surg,2011,127Suppl 1:177S-187S.DOI: 10.1097/PRS.0b013e3182001f0f. [79] Cortés-PenfieldNW,KulkarniPA.The history of antibiotic treatment of osteomyelitis[J].Open Forum Infect Dis,2019,6(5):ofz181.DOI: 10.1093/ofid/ofz181. [80] ConternoLO,TurchiMD.Antibiotics for treating chronic osteomyelitis in adults[J].Cochrane Database Syst Rev,2013,2013(9):CD004439.DOI: 10.1002/14651858.CD004439.pub3. [81] AkiyamaT,ChikudaH,YasunagaH,et al.Incidence and risk factors for mortality of vertebral osteomyelitis: a retrospective analysis using the Japanese diagnosis procedure combination database[J].BMJ Open,2013,3(3):e002412.DOI: 10.1136/bmjopen-2012-002412. [82] KurtzSM,LauE,WatsonH,et al.Economic burden of periprosthetic joint infection in the United States[J].J Arthroplasty,2012,27(8Suppl):61-65.e1.DOI: 10.1016/j.arth.2012.02.022. [83] ParkKH,ChoOH,LeeJH,et al.Optimal duration of antibiotic therapy in patients with hematogenous vertebral osteomyelitis at low risk and high risk of recurrence[J].Clin Infect Dis,2016,62(10):1262-1269.DOI: 10.1093/cid/ciw098. [84] 中华医学会骨科学分会创伤骨科学组,中华医学会骨科学分会外固定与肢体重建学组,中华医学会创伤学分会,等.中国-中亚五国骨折相关感染诊断与治疗指南(2024)[J].中华创伤骨科杂志,2024,26(1):6-15.DOI: 10.3760/cma.j.cn115530-20231101-00178. [85] InzanaJA,SchwarzEM,KatesSL,et al.Biomaterials approaches to treating implant-associated osteomyelitis[J].Biomaterials,2016,81:58-71.DOI: 10.1016/j.biomaterials.2015.12.012. [86] TanY,WangX,LiH,et al.The clinical efficacy of the vacuum-assisted closure therapy in the management of adult osteomyelitis[J].Arch Orthop Trauma Surg,2011,131(2):255-259.DOI: 10.1007/s00402-010-1197-x. [87] KarlakkiS,BremM,GianniniS,et al.Negative pressure wound therapy for managementof the surgical incision in orthopaedic surgery: A review of evidence and mechanisms for an emerging indication[J].Bone Joint Res,2013,2(12):276-284.DOI: 10.1302/2046-3758.212.2000190. [88] ZhuJ,WangF,YanL,et al.Negative pressure wound therapy enhances bone regeneration compared with conventional therapy in a rabbit radius gap-healing model[J].Exp Ther Med,2021,21(5):474.DOI: 10.3892/etm.2021.9905. [89] BonneSL,KadriSS.Evaluation and management of necrotizing soft tissue infections[J].Infect Dis Clin North Am,2017,31(3):497-511.DOI: 10.1016/j.idc.2017.05.011. [90] 王永进,王娟,何钢.皮肤及软组织感染临床诊治进展[J].临床误诊误治,2016,29(2):113-116. [91] MetsemakersWJ,MorgensternM,SennevilleE,et al.General treatment principles for fracture-related infection: recommendations from an international expert group[J].Arch Orthop Trauma Surg,2020,140(8):1013-1027.DOI: 10.1007/s00402-019-03287-4. [92] SimpsonAH,DeakinM,LathamJM.Chronic osteomyelitis. The effect of the extent of surgical resection on infection-free survival[J].J Bone Joint Surg Br,2001,83(3):403-407.DOI: 10.1302/0301-620x.83b3.10727. [93] DhageyIA,LiuZX,ZhongHF,et al.Pediatric calcaneal osteomyelitis: an analysis of literature-reported 128 cases[J].BMC Infect Dis,2024,24(1):998.DOI: 10.1186/s12879-024-09887-9. [94] NucciN,GazendamA,GouveiaK,et al.Management of infected extremity endoprostheses: a systematic review[J].Eur J Orthop Surg Traumatol,2020,30(7):1139-1149.DOI: 10.1007/s00590-020-02699-y. [95] PincherB,FentonC,JeyapalanR,et al.A systematic review of the single-stage treatment of chronic osteomyelitis[J].J Orthop Surg Res,2019,14(1):393.DOI: 10.1186/s13018-019-1388-2. [96] DoneganDJ,ScolaroJ,MatuszewskiPE,et al.Staged bone grafting following placement of an antibiotic spacer block for the management of segmental long bone defects[J].Orthopedics,2011,34(11):e730-735.DOI: 10.3928/01477447-20110922-16. [97] KashaS,RathoreSS,KumarH.Antibiotic cement spacer and induced membrane bone grafting in open fractures with bone loss: a case series[J].Indian J Orthop,2019,53(2):237-245.DOI: 10.4103/ortho.IJOrtho_110_17. [98] HatzenbuehlerJ,PullingTJ.Diagnosis and management of osteomyelitis[J].Am Fam Physician,2011,84(9):1027-1033. [99] 王欢,冯伟,夏芳,等.改良负压封闭引流技术治疗慢性骨及软组织感染[J].中华创伤骨科杂志,2012,14(10):908-910.DOI: 10.3760/cma.j.issn.1671-7600.2012.10.018. [100] ElliottJT,HendersonE,StreeterSS,et al.Fluorescence-guided and molecularly-guided debridement: identifying devitalized and infected tissue in orthopaedic trauma[J].Proc SPIE Int Soc Opt Eng,2023,12361:1236108 [pii].DOI: 10.1117/12.2661243. [101] JamesCV,PatelM,IlonzoN,et al.Hydrosurgical debridement use associated with decreased surgical site-related readmissions: a retrospective analysis[J].Wounds,2021,33(6):139-142. [102] ZamoraT,GarbuzDS,GreidanusNV,et al.An articulated spacer made of new primary implants in two-stage exchange for infected total knee arthroplasty may provide durable results[J].Bone Joint J,2020,102-B(7):852-860.DOI: 10.1302/0301-620X.102B7.BJJ-2019-1443.R1. [103] HuaH,ZhangL,GuoZ,et al.Antibiotic artificial bone implantation for the treatment of infection after internal fixation of tibial plateau fractures[J].BMC Musculoskelet Disord,2022,23(1):1142.DOI: 10.1186/s12891-022-06112-z. [104] 杜伟力,沈余明,胡骁骅,等.下肢关节部位外伤行骨科内固定手术后切口感染创面临床治疗方法探讨[J].中华烧伤杂志,2021,37(3):216-224.DOI: 10.3760/cma.j.cn501120-20201108-00463. [105] Gálvez-SirventE,Ibarzábal-GilA,Rodríguez-MerchánEC.Complications of the surgical treatment of fractures of the tibial plateau: prevalence, causes, and management[J].EFORT Open Rev,2022,7(8):554-568.DOI: 10.1530/EOR-22-0004. [106] MorgensternM,KuehlR,ZalavrasCG,et al.The influence of duration of infection on outcome of debridement and implant retention in fracture-related infection[J].Bone Joint J,2021,103-B(2):213-221.DOI: 10.1302/0301-620X.103B2.BJJ-2020-1010.R1. [107] Freire-ArcherM,SarrajM,KoziarzA,et al.Incidence and recurrence of deep spine surgical site infections: a systematic review and meta-analysis[J].Spine (Phila Pa 1976),2023,48(16):E269-E285.DOI: 10.1097/BRS.0000000000004713. [108] AtesokK,VaccaroA,StipplerM,et al.Fate of hardware in spinal infections[J].Surg Infect (Larchmt),2020,21(5):404-410.DOI: 10.1089/sur.2019.206. [109] AnantavorasakulN,LansJ,WolvetangN,et al.Forearm plate fixation: should plates be removed?[J].Arch Bone Jt Surg,2022,10(2):153-159.DOI: 10.22038/ABJS.2021.45901.2255. [110] RuppM,BärtlS,LangS,et al.Fracture-related infections after intramedullary nailing:diagnostics and treatment[J].Unfallchirurg,2022,125(1):50-58.DOI: 10.1007/s00113-021-01117-0. [111] ZhuK,HanS,ZhangZ,et al.Efficacy of antibiotic cement in preserving endoplants after infection with plate exposure[J].Surg Infect (Larchmt),2023,24(5):440-447.DOI: 10.1089/sur.2022.382. [112] BaertlS,RuppM,AltV.The DAIR-procedure in fracture-related infection-when and how[J].Injury,2024,55Suppl 6:111977.DOI: 10.1016/j.injury.2024.111977. [113] 李斌 陆维举 赵建宁 等 扩大清创一期植骨治疗长骨髓内钉术后感染性骨不连 第五届全国解剖与临床(骨科专题)学术研讨会暨人工关节高级论坛论文集 2009 267 268 李斌,陆维举,赵建宁,等.扩大清创一期植骨治疗长骨髓内钉术后感染性骨不连[C]//第五届全国解剖与临床(骨科专题)学术研讨会暨人工关节高级论坛论文集.2009:267-268.
[114] MarkelDC,BergumC,WuB,et al.Does suture type influence bacterial retention and biofilm formation after irrigation in a mouse model?[J].Clin Orthop Relat Res,2019,477(1):116-126.DOI: 10.1097/CORR.0000000000000391. [115] WintersB,Da Rin de Lorenzo F,BeckD.What is the treatment "algorithm" for infection after achilles tendon repair/reconstruction?[J]. Foot Ankle Int,2019,40(1_Suppl):71S-73S.DOI: 10.1177/1071100719861646. [116] TaleghaniER,ThompsonSR,YarboroSR,et al.Treatment algorithm for surgical site infections following extensor mechanism repair[J].JBJS Rev,2020,8(12):e20.00078.DOI: 10.2106/JBJS.RVW.20.00078. [117] KollrackY,MöllenhoffG.Vacuum therapy for deep wound infection after Achilles tendon repair[J].Z Orthop Unfall,2009,147(4):433-438.DOI: 10.1055/s-0029-1185348. [118] VossA,PfeiferCG,KerschbaumM,et al.Post-operative septic arthritis after arthroscopy: modern diagnostic and therapeutic concepts[J].Knee Surg Sports Traumatol Arthrosc,2021,29(10):3149-3158.DOI: 10.1007/s00167-021-06525-8. [119] Pérez-PrietoD,TotlisT,MadjarevicT,et al.ESSKA and EBJIS recommendations for the management of infections after anterior cruciate ligament reconstruction (ACL-R): prevention, surgical treatment and rehabilitation[J].Knee Surg Sports Traumatol Arthrosc,2023,31(10):4204-4212.DOI: 10.1007/s00167-023-07463-3. [120] 谢川江,石岭,朱纪峰,等.全膝关节置换术后假体周围感染的治疗策略[J].重庆医学,2021,50(1):100-104.DOI: 10.3969/j.issn.1671-8348.2021.01.023. [121] 汪胜,张亚鹏,左才红,等.关节镜清创滴注引流治疗儿童急性关节感染[J].中国矫形外科杂志,2020,28(15):1350-1353.DOI: 10.3977/j.issn.1005-8478.2020.15.02. [122] 宋长志,徐小卒,吴亚,等.关节镜下清创及灌洗引流治疗急性化脓性膝关节炎[J/OL].中华关节外科杂志(电子版),2019,13(2):237-241[2025-05-15].https://d.wanfangdata.com.cn/periodical/CiBQZXJpb2RpY2FsQ0hJU29scjkyMDI1MTExNzE2MDExNxIRemhnandrenoyMDE5MDIwMTgaCGloMnRjY2Ri.DOI: 10.3877/cma.j.issn.1674-134X.2019.02.018. [123] 宋海波,陈洁,刘宏,等.关节镜下清创治疗人工膝关节置换术后早期感染的临床分析[J].中国骨伤,2017,30(4):318-321.DOI: 10.3969/j.issn.1003-0034.2017.04.007. [124] GobbiA,KarnatzikosG,ChaurasiaS,et al.Postoperative infection after anterior cruciate ligament reconstruction[J].Sports Health,2016,8(2):187-189.DOI: 10.1177/1941738115618638. [125] FangXT,WoodKB.Management of postoperative instrumented spinal wound infection[J].Chin Med J (Engl),2013,126(20):3817-3821. [126] KoyonosL,ZmistowskiB,Della ValleCJ,et al.Infection control rate of irrigation and débridement for periprosthetic joint infection[J].Clin Orthop Relat Res,2011,469(11):3043-3048.DOI: 10.1007/s11999-011-1910-2. [127] SiddiqiA,AbdoZE,RossmanSR,et al.What is the optimal irrigation solution in the management of periprosthetic hip and knee joint infections?[J]. J Arthroplasty,2021,36(10):3570-3583.DOI: 10.1016/j.arth.2021.05.032. [128] ScuderiGR.Avoiding postoperative wound complications in total joint arthroplasty[J].J Arthroplasty,2018,33(10):3109-3112.DOI: 10.1016/j.arth.2018.01.025. [129] DeerenbergEB,HenriksenNA,AntoniouGA,et al.Updated guideline for closure of abdominal wall incisions from the European and American Hernia Societies[J].Br J Surg,2022,109(12):1239-1250.DOI: 10.1093/bjs/znac302. [130] BezstarostiH,Van LieshoutE,VoskampLW,et al.Insights into treatment and outcome of fracture-related infection: a systematic literature review[J].Arch Orthop Trauma Surg,2019,139(1):61-72.DOI: 10.1007/s00402-018-3048-0. [131] DarouicheRO.Treatment of infections associated with surgical implants[J].N Engl J Med,2004,350(14):1422-1429.DOI: 10.1056/NEJMra035415. [132] ZhaoX,ShenY.Island perforator muscle flaps for chronic osteomyelitis of the lower extremities: a retrospective analysis of 21 consecutive cases[J].Plast Reconstr Surg,2022,150(3):677-687.DOI: 10.1097/PRS.0000000000009472. [133] LariA,EsmaeilA,MarplesM,et al.Single versus two-stage management of long-bone chronic osteomyelitis in adults: a systematic review and meta-analysis[J].J Orthop Surg Res,2024,19(1):351.DOI: 10.1186/s13018-024-04832-7. [134] 王成,沈余明,覃凤均.应用股前外侧游离皮瓣移植治疗胫骨慢性骨髓炎的临床疗效观察[J].骨科临床与研究杂志,2020,5(2):111-115,121.DOI: 10.19548/j.2096-269x.2020.02.010. [135] CiernyG,MaderJT.Adult chronic osteomyelitis[J].Orthopedics,1984,7(10):1557-1564.DOI: 10.3928/0147-7447-19841001-07. [136] 刘文剑,张红艳,刘德伍.不同类型的组织瓣修复胫骨近端骨折术后钢板外露伴感染创面的临床效果[J].中华烧伤与创面修复杂志,2023,39(12):1140-1148.DOI: 10.3760/cma.j.cn501225-20231101-00171. [137] CiernyG.Surgical treatment of osteomyelitis[J].Plast Reconstr Surg,2011,127Suppl 1:190S-204S.DOI: 10.1097/PRS.0b013e3182025070. [138] 程琳,刘先奇,杜伟力,等.嵌合穿支皮瓣修复骨或内固定外露创面及骨髓炎创面的临床效果[J].中华烧伤与创面修复杂志,2024,40(7):643-649.DOI: 10.3760/cma.j.cn501225-20231120-00198. [139] GramlichY,ParviziJ.Enough is enough: salvage procedures in severe periprosthetic joint infection[J].Arthroplasty,2023,5(1):36.DOI: 10.1186/s42836-023-00182-7. [140] VayvadaH,DemirdoverC,MenderesA,et al.Necrotising fasciitis in the central part of the body: diagnosis, management and review of the literature[J].Int Wound J,2013,10(4):466-472.DOI: 10.1111/j.1742-481X.2012.01006.x. [141] GeurtsJ,HohnenA,VrankenT,et al.Treatment strategies for chronic osteomyelitis in low- and middle-income countries: systematic review[J].Trop Med Int Health,2017,22(9):1054-1062.DOI: 10.1111/tmi.12921. [142] RodhamP,PanteliM,VunJ,et al.Lower limb post-traumatic osteomyelitis: a systematic review of clinical outcomes[J].Eur J Orthop Surg Traumatol,2023,33(5):1863-1873.DOI: 10.1007/s00590-022-03364-2. [143] CerierE,ManerikarA,KandulaV,et al.Early initiation of physical and occupational therapy while on extracorporeal life support improves patients' functional activity[J].Artif Organs,2023,47(5):870-881.DOI: 10.1111/aor.14446. [144] DitmyerMM,ToppR,PiferM.Prehabilitation in preparation for orthopaedic surgery[J].Orthop Nurs,2002,21(5):43-51; quiz 52-54.DOI: 10.1097/00006416-200209000-00008. [145] BentleyJA,BruyèreSM,LeBlancJ,et al.Globalizing rehabilitation psychology: application of foundational principles to global health and rehabilitation challenges[J].Rehabil Psychol,2016,61(1):65-73.DOI: 10.1037/rep0000068. [146] Herrera-LigeroC,ChalerJ,Bermejo-BoschI.Strengthening education in rehabilitation: assessment technology and digitalization[J].Front Rehabil Sci,2022,3:883270.DOI: 10.3389/fresc.2022.883270. [147] 北京医学会创伤学分会护理学组,国家骨科医学中心骨科加速康复外科联盟,李庭,等.加速康复外科理念下骨科围手术期健康教育方案优化的专家共识[J].骨科临床与研究杂志,2024,9(4):197-202.DOI: 10.19548/j.2096-269x.2024.04.002. [148] ZhangX,ButtsWJ,YouT.Exercise interventions, physical function, and mobility after hip fracture: a systematic review and meta-analysis[J].Disabil Rehabil,2022,44(18):4986-4996.DOI: 10.1080/09638288.2021.1924299. [149] 中国康复医学会骨与关节分会创伤骨科学组,王金辉,葛宇峰,等.骨科康复一体化模式下骨盆骨折围手术期康复治疗技术规范专家共识[J].中华创伤骨科杂志,2021,23(10):829-836.DOI: 10.3760/cma.j.cn115530-20210806-00368. [150] PedrosaGF,LimaFV,SchoenfeldBJ,et al.Partial range of motion training elicits favorable improvements in muscular adaptations when carried out at long muscle lengths[J].Eur J Sport Sci,2022,22(8):1250-1260.DOI: 10.1080/17461391.2021.1927199. [151] KarlssonÅ,LindelöfN,OlofssonB,et al.Effects of geriatric interdisciplinary home rehabilitation on independence in activities of daily living in older people with hip fracture: a randomized controlled trial[J].Arch Phys Med Rehabil,2020,101(4):571-578.DOI: 10.1016/j.apmr.2019.12.007. [152] MlinacME,FengMC.Assessment of activities of daily living, self-care, and independence[J].Arch Clin Neuropsychol,2016,31(6):506-516.DOI: 10.1093/arclin/acw049. -
Table 1. 2011版牛津大学循证医学中心证据等级标准
证据等级 具体描述 1级 基于随机对照试验或单人交叉临床试验的系统性文献回顾,对随机性研究的系统综述 2级 随机对照试验或效果显著的观察性研究 3级 非随机性、对照性队列研究或随访研究 4级 病例系列、病例对照研究或历史对照研究 5级 基于机制的推论 -



下载: