智能敷料的研究和临床转化

吕国忠; 赵朋

doi:10.3760/cma.j.cn501225-20250807-00348

智能敷料的研究和临床转化

doi: 10.3760/cma.j.cn501225-20250807-00348

吕国忠^,,
赵朋

江南大学附属医院烧创伤诊疗中心,江南大学教育部创面修复技术工程研究中心,无锡　　214122

基金项目:

国家重点研发计划 2022YFC3006200

江苏省科技厅社会发展临床前沿技术项目 BE2018626

详细信息

通讯作者:
吕国忠,Email：luguozhong@jiangnan.edu.cn

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出版历程
- 收稿日期: 2025-08-07

Researches and clinical translation of smart dressings

Lyu Guozhong^,,
Zhao Peng

Engineering Research Center of the Ministry of Education for Wound Repair Technology of Jiangnan University, Burn and Trauma Treatment Center, Affiliated Hospital of Jiangnan University, Wuxi 214122, China

Funds:

National Key Research and Development Program of China 2022YFC3006200

Clinical Frontier Technology Program of Social Development of Science and Technology Agency of Jiangsu Province of China BE2018626

More Information

Corresponding author: Lyu Guozhong, Email: luguozhong@jiangnan.edu.cn

摘要

摘要: 智能敷料的研究和应用是烧伤、创面修复等领域关注的热点。微型化电子元器件、光纤和无线通信技术、柔性电路研究的突破,以及新型生物材料的研发,为智能敷料的开发和应用奠定了基础。实时、快速响应、多功能的智能敷料不断出现,在创面感染的早期识别、炎症反应的评估、创面性质改变的监测、创面愈合方向和时间的评估等方面显示出巨大潜力,也为创面局部药物精准、可控递送及微电流刺激治疗提供契机。该文介绍了智能敷料的分类、研究进展和临床试验情况,按有源和无源分类分析了传感智能敷料的功能、优点和不足,介绍了3类广义的、能识别创面各参数变化并做出反应（如变色、释放药物或微电流）的非传感智能敷料。在此基础上,该文还对智能敷料的未来进行了展望。
- 机敏材料 /
- 生物相容性材料 /
- 生物传感技术 /
- 创面修复 /
- 微环境
Abstract: The research and application of smart dressings are a focal point in fields such as burn and wound repair. Breakthroughs in miniaturized electronic components, fiber optics and wireless communication technologies, and flexible circuit, and the research and development of novel biomaterials have laid foundation for the development and application of smart dressings. Real-time, rapid-response, multifunctional smart dressings are emerging, showing great potential in aspects such as early detection of wound infections, assessment of inflammatory responses, monitoring changes in wound characteristics, and estimating wound healing direction and duration. They also provide opportunities for precise and controlled local drug delivery to wounds and microcurrent stimulation therapy. This article introduces the classification, research progress, and clinical trials of smart dressings, and analyzes the functions, advantages, and limitations of sensor-based smart dressings by categorizing them into active and passive types. Additionally, this article introduces three types of broadly defined, non-sensor-based smart dressings that can identify changes in specific wound parameters and respond accordingly such as changing color, releasing drugs, or exhibiting microcurrent. Based on this, the article also provides an outlook on the future of smart dressings.
- Smart materials /
- Biocompatible materials /
- Biosensing techniques /
- Wound repair /
- Microenvironment
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