靶向程序性细胞死亡调控网络治疗糖尿病难愈创面的研究进展

张子晗; 贺伟峰

doi:10.3760/cma.j.cn501225-20251106-00460

靶向程序性细胞死亡调控网络治疗糖尿病难愈创面的研究进展

doi: 10.3760/cma.j.cn501225-20251106-00460

张子晗,
贺伟峰^,

陆军军医大学（第三军医大学）第一附属医院全军烧伤研究所,创伤与化学中毒国家重点实验室,重庆市创面修复与组织再生重点实验室,重庆　400038

基金项目:

国家自然科学基金面上项目 82172232, 82472568

重庆市自然科学基金创新发展联合基金重点项目 CSTB2024NSCQ-LZX0057

详细信息

通讯作者:
贺伟峰,Email：heweifeng@tmmu.edu.cn

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- 被引次数: 0
出版历程
- 收稿日期: 2025-11-06
- 网络出版日期: 2026-03-23

Research advances on the targeted programmed cell death regulatory network for treatment of refractory diabetic wounds

Zhang Zihan,
He Weifeng^,

Institute of Burn Research, State Key Laboratory of Trauma and Chemical Poisoning, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing Key Laboratory for Wound Repair and Tissue Regeneration, Chongqing 400038, China

Funds:

General Program of National Natural Science Foundation of China 82172232, 82472568

Key Program of Chongqing Natural Science Foundation Innovation and Development Joint Fund CSTB2024NSCQ-LZX0057

More Information

Corresponding author: He Weifeng, Email: heweifeng@tmmu.edu.cn

摘要

摘要: 糖尿病难愈创面是糖尿病严重并发症,传统治疗效果有限。近年研究表明,其病理核心在于高糖微环境导致的程序性细胞死亡调控网络失调,具体表现为坏死性凋亡、铁死亡、焦亡等裂解性细胞死亡过度激活驱动炎症持续；凋亡、保护性细胞自噬等非裂解性细胞死亡受损及胞葬作用障碍导致炎症消退程序受阻。各死亡途径通过共享调控枢纽和下游信号串扰形成动态网络,最终使创面陷入“死亡—炎症—修复障碍”的恶性循环。该文系统阐述糖尿病创面中程序性细胞死亡调控网络的失调特征、交互机制,并探讨组合疗法与精准分层治疗的应用前景。
- 糖尿病足 /
- 伤口愈合 /
- 炎症 /
- 细胞死亡 /
- 分子靶向治疗
Abstract: Refractory diabetic wounds are severe complications of diabetes mellitus, for which conventional treatments yield limited efficacy. Recent studies have demonstrated that the core pathogenesis lies in the dysregulation of the programmed cell death regulatory network induced by the hyperglycemic microenvironment. Specifically, excessive activation of lytic cell death such as necroptosis, ferroptosis, and pyroptosis drives persistent inflammation; while impairment of non-lytic cell death including apoptosis and cytoprotective autophagy as well as efferocytosis dysfunction results in impaired initiation of the inflammation resolution program. Distinct cell death pathways form a dynamic network through shared regulatory hubs and downstream signaling crosstalk, ultimately locking the wound in a vicious cycle of "cell death—inflammation—repair impairment". This review systematically elaborates on the dysregulation characteristics and interaction mechanisms of the programmed cell death regulatory network in diabetic wounds, and discusses the application prospects of combination therapies and precision stratified treatment.
- Diabetic foot /
- Wound healing /
- Inflammation /
- Cell death /
- Molecular targeted therapy
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