On 18th October 2018, a 49 years old man with right thigh proximal medial swelling and pain was received in the Department of Pathology, People′s Hospital of Deyang of Sichuan Province. The patient had experienced amputation twice because of burn in right lower limb 46 years ago. Cicatricial squamous cell carcinoma metastasis in right thigh proximal medial was diagnosed by fine needle aspiration cytology in our hospital. The wound remained ulcered and unhealed after biopsy in a higher level hospital. The patient died in ten days after first chemotherapy which was required by the patient. This case suggests that clinician should perform pathological examination on burn patients with scar ulcer as soon as possible to avoid delay in treatment, which may cause carcinogenesis deterioration and metastasis.