2022 Vol. 38, No. 7

Guidelines and Consensuses
National expert consensus on prone position therapy in adult burn patients (2022 version)
The Burn and Trauma Branch of Chinese Geriatrics Society, Critical Care Group of Chinese Burn Association
2022, 38(7): 601-609. doi: 10.3760/cma.j.cn501120-20211208-00407
Abstract:
Prone position ventilation (PPV) is attracting more and more attention as a part of mechanical ventilation treatment, and relevant consensus and guidelines have been formulated. Prone position therapy (PPT) is widely used in the clinical diagnosis and treatment of burns. Compared with traditional PP...
Expert Forum
Progress and thoughts on the regulation of wound repair by growth factors
Xiao Jian, Zhang Fan
2022, 38(7): 610-615. doi: 10.3760/cma.j.cn501225-20220416-00139
Abstract:
Growth factors play an important role in wound healing, and they mainly accelerate wound healing by activating the related signal pathways. Chinese scientists have been conducting basic and clinical researches on growth factors for 30 years, with a series of growth factor drugs being developed and w...
Original Aticles·The Role of Growth Factors in Wound Healing
Effects of in situ cross-linked graphene oxide-containing gelatin methacrylate anhydride hydrogel on wound vascularization of full-thickness skin defect in mice
Liang Liting, Song Wei, Zhang Chao, Li Zhao, Yao Bin, Zhang Mengde, Yuan Xingyu, Enhejirigala, Fu Xiaobing, Huang Sha, Zhu Ping
2022, 38(7): 616-628. doi: 10.3760/cma.j.cn501225-20220314-00063
Abstract:
Objective To prepare graphene oxide (GO)-containing gelatin methacrylate anhydride (GelMA) hydrogel and to investigate the effects of in situ photopolymerized GO-GelMA composite hydrogel in wound vascularization of full-thickness skin defect in mice. Methods The experimental study method was used. T...
Investigation on the growth factor regulatory network of dermal fibroblasts in mouse full-thickness skin defect wounds based on single-cell RNA sequencing
Sun Lixiang, Wu Shuai, Zhang Xiaowei, Liu Wenjie, Zhang Lingjuan
2022, 38(7): 629-639. doi: 10.3760/cma.j.cn501225-20220215-00029
Abstract:
Objective To explore the heterogeneity and growth factor regulatory network of dermal fibroblasts (dFbs) in mouse full-thickness skin defect wounds based on single-cell RNA sequencing. Methods The experimental research methods were adopted. The normal skin tissue from 5 healthy 8-week-old male C57BL...
Effects of methacrylic anhydride gelatin hydrogel loaded with silver and recombinant human basic fibroblast growth factor on deep partial-thickness burn wounds in rabbits
Chen Xiangjun, Wu Xing, Lin Huanhuan, Liu Zhaoxing, Liu Sha
2022, 38(7): 640-649. doi: 10.3760/cma.j.cn501120-20210726-00260
Abstract:
Objective To investigate the effects of methacrylic anhydride gelatin (GelMA) hydrogel loaded with silver and recombinant human basic fibroblast growth factor (rh-bFGF) on deep partial-thickness burn wounds in rabbits. Methods The experimental research method was adopted. Low-concentration GelMA mat...
Original Articles
Feasibility study on the preparation of novel negative pressure materials for constructing new matrix of full-thickness skin defect wounds in rats
Liu Yifan, Jiang Zhaoqi, Huang Yao, Ni Pengwen, Xie Ting
2022, 38(7): 650-660. doi: 10.3760/cma.j.cn501120-20210401-00113
Abstract:
Objective To explore the feasibility on the preparation of novel negative pressure materials for constructing new matrix of full-thickness skin defect wounds in rats. Methods The experimental research method was applied. The microstructure of polyurethane foam dressing which was commonly used in neg...
Clinical effects of free peroneal artery perforator flaps in repairing forefoot skin and soft tissue defect wounds assisted with three-dimensional computed tomography angiography
Wang Chengde, Wang Ai, Sun Jiling, Ma Wenguo, Wang Jianguo
2022, 38(7): 661-666. doi: 10.3760/cma.j.cn501120-20210914-00317
Abstract:
Objective To investigate the clinical effects of free peroneal artery perforator flaps in repairing forefoot skin and soft tissue defect wounds assisted with three-dimensional computed tomography angiography (3D-CTA). Methods A retrospective observational study was conducted. From March 2017 to Sept...
Effects and molecular mechanism of exogenous L-carnitine on excessive endoplasmic reticulum stress-mediated hepatic pyroptosis in severely scald rats
Fan Fuxiao, Li Pengtao, Xia Zhengguo, Xie Chaoqiong, Xu Jiegou, Xu Qinglian
2022, 38(7): 667-676. doi: 10.3760/cma.j.cn501225-20220120-00010
Abstract:
Objective To investigate the effects and molecular mechanism of exogenous L-carnitine on hepatic pyroptosis mediated by excessive endoplasmic reticulum stress in severely scald rats. Methods The experimental research method was adopted. According to the random number table (the same group method bel...
Clinical effects of free hallux-nail flap combined with the second toe composite tissue flap in the reconstruction of damaged thumb after electrical burns
Xing Peipeng, Mu Xinling, Xia Chengde, Shi Jijing, Xue Jidong, Yang Gaoyuan, Zhang Jian, Di Haiping
2022, 38(7): 677-682. doi: 10.3760/cma.j.cn501120-20210621-00222
Abstract:
Objective To explore the clinical effects of free hallux-nail flap combined with the second toe composite tissue flap in the reconstruction of damaged thumb after electrical burns. Methods A retrospective observational study was conducted. From May 2018 to April 2021, 12 male patients with thumb des...
A prospective randomized controlled study on the effects of compound analgesia in ultra-pulsed fractional carbon dioxide laser treatment of post-burn hypertrophic scars in children
Yang Jiao, Shi Shan, Wang Ling, Li Na, Han Juntao, Hu Dahai
2022, 38(7): 683-690. doi: 10.3760/cma.j.cn501120-20210507-00171
Abstract:
Objective To investigate the effects of compound analgesia on ultra-pulsed fractional carbon dioxide laser (UFCL) treatment of post-burn hypertrophic s in children. Methods A prospective randomized controlled study was conducted. From April 2018 to March 2020, 169 pediatric patients with post-burn h...
Reviews
Research advances on biomaterials for the delivery of growth factors to regulate wound repair
Weng Tingting, Cai Chenghao, Han Chunmao, Wang Xingang
2022, 38(7): 691-696. doi: 10.3760/cma.j.cn501225-20220430-00166
Abstract:
Wound repair is a highly coordinated and mutually regulated complex process involving various kinds of cells, extracellular matrices and cytokines. A variety of growth factors play an important regulatory role in wound healing, and it is critical to achieve effective delivery and sustained function ...
Research advances on the application of carbon dots in wound treatment
Wang Peng, Wang Guangyi, Ji Shizhao, Ma Jianming, Tang Tao
2022, 38(7): 697-704. doi: 10.3760/cma.j.cn501120-20210709-00242
Abstract:
Chronic and infectious wound healing has always been an issue of concern in clinical and scientific research, in which bacterial infection and oxidative damage are the key factors hindering wound healing. Carbon dots, as a new material, has attracted much attention because of its unique physical and...