Volume 38 Issue 7
Jul.  2022
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Xiao J,Zhang F.Progress and thoughts on the regulation of wound repair by growth factors[J].Chin J Burns Wounds,2022,38(7):610-615.DOI: 10.3760/cma.j.cn501225-20220416-00139.
Citation: Xiao J,Zhang F.Progress and thoughts on the regulation of wound repair by growth factors[J].Chin J Burns Wounds,2022,38(7):610-615.DOI: 10.3760/cma.j.cn501225-20220416-00139.

Progress and thoughts on the regulation of wound repair by growth factors

doi: 10.3760/cma.j.cn501225-20220416-00139
Funds:

Excellent Young Program of National Natural Science Foundation of China 81722028

Wenzhou Science and Technology Innovation Project ZY2020023

More Information
  • Corresponding author: Xiao Jian, Email: xfxj2000@126.com
  • Received Date: 2022-04-16
  • Growth factors play an important role in wound healing, and they mainly accelerate wound healing by activating the related signal pathways. Chinese scientists have been conducting basic and clinical researches on growth factors for 30 years, with a series of growth factor drugs being developed and widely used in the treatment of burns and trauma and chronic refractory ulcers. This paper expounds the frontier progress of growth factors on wound healing from the perspectives of immunity, nerve, fat, and so on, and puts forward the further thoughts of the research team on the regulation of wound healing by growth factors.

     

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  • [1]
    付小兵, 李校堃.从第一个用于创烧伤治疗的基因工程国家一类新药研发与转化应用看创烧伤治疗“中国方案”的创立[J].中华烧伤与创面修复杂志,2022,38(1):4-8.DOI: 10.3760/cma.j.cn501120-20211125-00397.
    [2]
    付小兵.治疗创烧伤国家一类新药基因工程生长因子的研发与转化应用:主要历程与思索[J].中华创伤杂志,2018,34(12):1057-1061.DOI: 10.3760/cma.j.issn.1001-8050.2018.12.001.
    [3]
    李校堃.坚持梦想 不负韶华:生长因子与创面修复三十年自主创新之路[J].中华烧伤杂志,2020,36(3):161-165.DOI: 10.3760/cma.j.cn501120-20200305-00125.
    [4]
    中华医学会烧伤外科学分会,《中华烧伤杂志》编辑委员会.皮肤创面外用生长因子的临床指南[J].中华烧伤杂志,2017,33(12):721-727.DOI: 10.3760/cma.j.issn.1009-2587.2017.12.001.
    [5]
    HanCM,ChengB,WuP.Clinical guideline on topical growth factors for skin wounds[J/OL].Burns Trauma,2020,8:tkaa035[2022-04-16]. https://academic.oup.com/burnstrauma/article/doi/ 10.1093/burnst/tkaa035/5912276?login=true.DOI: 10.1093/burnst/tkaa035.
    [6]
    WeiYT, LiJF, HuangY, et al.The clinical effectiveness and safety of using epidermal growth factor, fibroblast growth factor and granulocyte-macrophage colony stimulating factor as therapeutics in acute skin wound healing: a systematic review and meta-analysis[J/OL].Burns Trauma,2022,10:tkac002[2022-04-16]. https://academic.oup.com/burnstrauma/article-lookup/doi/ 10.1093/burnst/tkac002.DOI: 10.1093/burnst/tkac002.
    [7]
    GragnaniA, TonarelliE, ChomiskiV, et al.Fibroblast growth factor in the treatment of burns: a systematic review[J].Burns,2022,48(1):104-110.DOI: 10.1016/j.burns.2021.04.006.
    [8]
    AbdelhakimM, LinXX, OgawaR.The Japanese experience with basic fibroblast growth factor in cutaneous wound management and scar prevention: a systematic review of clinical and biological aspects[J].Dermatol Ther (Heidelb),2020,10(4):569-587.DOI: 10.1007/s13555-020-00407-6.
    [9]
    FergusonMWJ, DuncanJ, BondJ, et al.Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase Ⅰ/Ⅱ studies[J].Lancet,2009,373(9671):1264-1274.DOI: 10.1016/S0140-6736(09)60322-6.
    [10]
    NestorMS, BermanB, FischerDL, et al.A randomized, double-blind, active- and placebo-controlled trial evaluating a novel topical treatment for keloid scars[J].J Drugs Dermatol,2021,20(9):964-968.DOI: 10.36849/jdd.6197.
    [11]
    KohaviL, SprecherE, ZurE, et al.The effect of tranilast 8% liposomal gel versus placebo on post-cesarean surgical scars: a prospective double-blind split-scar study[J].Dermatol Surg,2017,43(9):1157-1163.DOI: 10.1097/DSS.0000000000001140.
    [12]
    ChenG,AnN,YeWJ,et al.bFGF alleviates diabetes-associated endothelial impairment by downregulating inflammation via S-nitrosylation pathway[J].Redox Biol,2021,41:101904.DOI: 10.1016/j.redox.2021.101904.
    [13]
    SunJ,HuangXZ,NiuC,et al.aFGF alleviates diabetic endothelial dysfunction by decreasing oxidative stress via Wnt/β-catenin-mediated upregulation of HXK2[J].Redox Biol,2021,39:101811.DOI: 10.1016/j.redox.2020.101811.
    [14]
    ChenXX, TongGZ, FanJF, et al.FGF21 promotes migration and differentiation of epidermal cells during wound healing via SIRT1-dependent autophagy[J].Br J Pharmacol,2022,179(5):1102-1121.DOI: 10.1111/bph.15701.
    [15]
    ZhouKL, ChenHW, LinJT, et al.FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival[J].Cell Death Dis,2019,10(12):872.DOI: 10.1038/s41419-019-2105-0.
    [16]
    ZhouQD,GongJX,BiJN,et al.KGF-2 regulates STAP-2- mediated signal transducer and activator of transcription 3 signaling and reduces skin scar formation[J].J Invest Dermatol,2022,142(7):2003-2013.e5.DOI: 10.1016/j.jid.2021.12.018.
    [17]
    XuJJ,ZanvitP,HuL,et al.The cytokine TGF-β induces interleukin-31 expression from dermal dendritic cells to activate sensory neurons and stimulate wound itching[J].Immunity,2020,53(2):371-383.e5.DOI: 10.1016/j.immuni.2020.06.023.
    [18]
    SobeckiM, KrzywinskaE, NagarajanS, et al.NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence[J].Nat Commun,2021,12(1):4700.DOI: 10.1038/s41467-021-25065-w.
    [19]
    KumarS, YarmushML, DashBC, et al.Impact of complete spinal cord injury on healing of skin ulcers in mouse models[J].J Neurotrauma,2018,35(6):815-824.DOI: 10.1089/neu.2017.5405.
    [20]
    BarkerAR, RossonGD, DellonAL.Wound healing in denervated tissue[J].Ann Plast Surg,2006,57(3):339-342.DOI: 10.1097/01.sap.0000221465.69826.b7.
    [21]
    AshrafiM, BaguneidM, BayatA.The role of neuromediators and innervation in cutaneous wound healing[J].Acta Derm Venereol,2016,96(5):587-594.DOI: 10.2340/00015555-2321.
    [22]
    ShookBA, WaskoRR, Rivera-GonzalezGC, et al.Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair[J].Science,2018,362(6417):eaar2971.DOI: 10.1126/science.aar2971.
    [23]
    ZhangLJ,ChenSX,Guerrero-JuarezCF,et al.Age-related loss of innate immune antimicrobial function of dermal fat is mediated by transforming growth factor beta[J].Immunity,2019,50(1):121-136.e5.DOI: 10.1016/j.immuni.2018.11.003.
    [24]
    ZhangLJ, Guerrero-JuarezCF, ChenSX, et al.Diet-induced obesity promotes infection by impairment of the innate antimicrobial defense function of dermal adipocyte progenitors[J].Sci Transl Med,2021,13(577):eabb5028.DOI: 10.1126/scitranslmed.abb5280.
    [25]
    MochizukiM,GüçE,ParkAJ,et al.Growth factors with enhanced syndecan binding generate tonic signalling and promote tissue healing[J].Nat Biomed Eng,2020,4(4):463-475.DOI: 10.1038/s41551-019-0469-1.
    [26]
    MartinoMM,BriquezPS,GüçE,et al.Growth factors engineered for super-affinity to the extracellular matrix enhance tissue healing[J].Science,2014,343(6173):885-888.DOI: 10.1126/science.1247663.
    [27]
    IshiharaJ, IshiharaA, StarkeRD, et al.The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing[J].Blood,2019,133(24):2559-2569.DOI: 10.1182/blood.2019000510.
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