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Volume 37 Issue 10
Oct.  2021
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2021  >  37(10): 990-995
Li YL,Chen N,Xie WG.Research advances on the application of platelet concentrate products in wound repair[J].Chin J Burns,2021,37(10):990-995.DOI: 10.3760/cma.j.cn501120-20200730-00363.
Citation: Li YL,Chen N,Xie WG.Research advances on the application of platelet concentrate products in wound repair[J].Chin J Burns,2021,37(10):990-995.DOI: 10.3760/cma.j.cn501120-20200730-00363.
shu

Research advances on the application of platelet concentrate products in wound repair

doi: 10.3760/cma.j.cn501120-20200730-00363

  • Institute of Burns, Tongren Hospital of Wuhan University & Wuhan Third Hospital, Wuhan 430060, China

Funds:

General Program of National Natural Science Foundation of China 81772097

Action Plan for Science and Technology in Major Disease Prevention and Control 2018-ZX-01S-001

More Information
  • Corresponding author: Xie Weiguo, Email: wgxie@hotmail.com
  • Received Date: 2020-07-30
    Abstract
  • Multiple growth factors are required to regulate the wound repair process. Currently, there is still a lack of potent, durable, and inexpensive growth factor product in clinical practice. Meanwhile, platelet concentrate products provide an economical, convenient, and effective choice for the treatment of wounds in clinical practice. Starting from the first generation of platelet concentrate products, platelet-rich plasma, researchers have focused on optimizing the performance of platelet concentrate products for higher stability, more abundant bioactive factors, and more optimal clinical performance. Platelet-rich fibrin and concentrated growth factor emerged since then. Platelet concentrate products have the effect of promoting the speed of wound healing and enhancing the quality. This article aims to summarize the history and classification of platelet concentrate products, compare their properties and clinical applications, elaborate their mechanism of action, and analyze the problems existing in relevant researches while prospecting the future development of this field.

     

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  • [1]
    CooperDM,YuEZ,HennesseyP,et al.Determination of endogenous cytokines in chronic wounds[J].Ann Surg,1994,219(6):688-691; discussion 691-692.DOI: 10.1097/00000658-199406000-00012.
    [2]
    PierceGF,TarpleyJE,TsengJ,et al.Detection of platelet-derived growth factor (PDGF)-AA in actively healing human wounds treated with recombinant PDGF-BB and absence of PDGF in chronic nonhealing wounds[J].J Clin Invest,1995,96(3):1336-1350.DOI: 10.1172/JCI118169.
    [3]
    ImandtL,GendersT,WesselsH,et al.An improved method for preparing platelet-rich plasma[J].Thromb Res,1977,11(3):429-432.DOI: 10.1016/0049-3848(77)90195-5.
    [4]
    AndersonGM,YoungJG,CohenDJ,et al.Liquid-chromatographic determination of serotonin and tryptophan in whole blood and plasma[J].Clin Chem,1981,27(5):775-776.
    [5]
    MarxRE,CarlsonER,EichstaedtRM,et al.Platelet-rich plasma: growth factor enhancement for bone grafts[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endod,1998,85(6):638-646.DOI: 10.1016/s1079-2104(98)90029-4.
    [6]
    DohanDM,ChoukrounJ,DissA,et al.Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part Ⅰ: technological concepts and evolution[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endod,2006,101(3):e37-44.DOI: 10.1016/j.tripleo.2005.07.008.
    [7]
    DohanDM,ChoukrounJ,DissA,et al.Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part Ⅱ: platelet-related biologic features[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endod,2006,101(3):e45-50.DOI: 10.1016/j.tripleo.2005.07.009.
    [8]
    DohanDM, CorsoMD,CharrierJB. Cytotoxicity analyses of Choukroun's platelet-rich fibrin (PRF) on a wide range of human cells: the answer to a commercial controversy[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2007, 103(5):587-593. DOI: 10.1016/j.tripleo.2007.03.016.
    [9]
    Dohan EhrenfestDM, AndiaI, ZumsteinMA, et al. Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives[J]. Muscles Ligaments Tendons J, 2014, 4(1): 3-9.
    [10]
    Dohan EhrenfestDM,RasmussonL,AlbrektssonT.Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)[J].Trends Biotechnol,2009,27(3):158-167.DOI: 10.1016/j.tibtech.2008.11.009.
    [11]
    张昭远,卫愉轩,张长青,等.应用不同离心条件优化富白细胞富血小板血浆制作方案研究[J].中国修复重建外科杂志,2020,34(8):1025-1030.DOI: 10.7507/1002-1892.201911054.
    [12]
    王旭竹可注射型富血小板纤维蛋白在组织再生中的作用武汉武汉大学2018

    王旭竹. 可注射型富血小板纤维蛋白在组织再生中的作用[D]. 武汉:武汉大学, 2018.
    [13]
    JinRZ,SongGT,ChaiJH,et al.Effects of concentrated growth factor on proliferation, migration, and differentiation of human dental pulp stem cells in vitro[J].J Tissue Eng,2018,9:2041731418817505.DOI: 10.1177/2041731418817505.
    [14]
    MasukiH,OkuderaT,WatanebeT,et al.Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF), and concentrated growth factors (CGF)[J].Int J Implant Dent,2016,2(1):19.DOI: 10.1186/s40729-016-0052-4.
    [15]
    陈滔,郑鑫,黄杨,等.富血小板血浆通过调节SDF-1/CXCR4信号通路影响糖尿病皮瓣新生血管化机制的研究[J].中华全科医学,2016,14(6):953-956.DOI: 10.16766/j.cnki.issn.1674-4152.2016.06.022.
    [16]
    XuPC,WuYG,ZhouLN,et al.Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization[J/OL].Burns Trauma,2020,8:tkaa028[2021-07-30]. https://pubmed.ncbi.nlm.nih.gov/32821743/.DOI: 10.1093/burnst/tkaa028.
    [17]
    熊隆江,李思云,黄晓蓬,等.自体骨软骨移植联合富血小板血浆对兔膝关节骨软骨缺损的修复作用及机制[J].医学理论与实践,2020,33(5):689-691,694.DOI: 10.19381/j.issn.1001-7585.2020.05.001.
    [18]
    张晓洁,许胜,孟维艳,等.富血小板纤维蛋白提取液对钛表面成骨细胞黏附、增殖及分化的影响[J].中华口腔医学杂志,2017,52(1):48-52.DOI: 10.3760/cma.j.issn.1002-0098.2017.01.010.
    [19]
    杨世茂,王明国,李静,等.富血小板纤维蛋白与富血小板血浆体外释放生长因子的比较及其对脂肪干细胞增殖分化的影响[J].华西口腔医学杂志,2012,30(6):641-644,649.DOI: 10.3969/j.issn.1000-1182.2012.06.019.
    [20]
    辛酉凤, 赵金, 董子龙,等. 富血小板纤维蛋白(PRF)在糖尿病皮肤溃疡愈合中的应用及可能的作用机制探讨[J/CD]. 临床医药文献电子杂志, 2019, 6(46): 23-24. DOI: 10.16281/j.cnki.jocml.2019.46.014.
    [21]
    卓然, 王杨, 刘刚,等. PRF对糖尿病大鼠创面Wnt/β-catenin信号通路的影响[J]. 医学研究杂志, 2019, 48(9): 95-98,65. DOI: 10.11969/j.issn.1673-548X.2019.09.021.
    [22]
    DongK,HaoPJ,ZhouWJ,et al.Concentrate growth factors regulate osteogenic dysfunction of MC3T3-E1 cells induced by high glucose through PI3K/Akt signaling pathway[J].Implant Dent,2019,28(5):478-483.DOI: 10.1097/ID.0000000000000921.
    [23]
    QiL,LiuL,HuY,et al.Concentrated growth factor promotes gingival regeneration through the AKT/Wnt/β-catenin and YAP signaling pathways[J].Artif Cells Nanomed Biotechnol,2020,48(1):920-932.DOI: 10.1080/21691401.2020.1773482.
    [24]
    MarckRE,MiddelkoopE,BreederveldRS.Considerations on the use of platelet-rich plasma, specifically for burn treatment[J].J Burn Care Res,2014,35(3):219-227.DOI: 10.1097/BCR.0b013e31829b334e.
    [25]
    刘哲伟, 苏开新, 陈军,等. 富含血小板血浆外敷在深Ⅱ度烧伤创面修复中的临床应用[J]. 天津医药, 2014, 42(12): 1213-1215. DOI: 10.3969/j.issn.0253-9896.2014.12.017.
    [26]
    Martinez-ZapataMJ,Martí-CarvajalAJ,SolàI,et al.Autologous platelet-rich plasma for treating chronic wounds[J].Cochrane Database Syst Rev,2016(5):CD006899.DOI: 10.1002/14651858.CD006899.pub3.
    [27]
    PrabhuR,VijayakumarC,Bosco ChandraAA,et al.Efficacy of homologous, platelet-rich plasma dressing in chronic non- healing ulcers: an observational study[J].Cureus,2018,10(2):e2145.DOI: 10.7759/cureus.2145.
    [28]
    ElbarbaryAH,HassanHA,ElbendakEA.Autologous platelet- rich plasma injection enhances healing of chronic venous leg ulcer: a prospective randomised study[J].Int Wound J,2020,17(4):992-1001.DOI: 10.1111/iwj.13361.
    [29]
    杨荣华,林泽鹏,信琪,等.负压创面联合富血小板血浆对慢性难愈性创面患者疼痛及炎症指标的影响[J].黑龙江医药,2020,33(3):523-526.DOI: 10.14035/j.cnki.hljyy.2020.03.015.
    [30]
    杨荣华,阮树斌,林泽鹏,等.富血小板血浆治疗糖尿病足难愈性创面的作用研究[J].中国实用医药,2020,15(20):47-49.DOI: 10.14163/j.cnki.11-5547/r.2020.20.017.
    [31]
    李婷,孟涛,刘斌焰,等.自体富血小板血浆治疗糖尿病慢性皮肤溃疡疗效的Meta分析[J].中国老年学杂志,2020,40(14):2952-2958.DOI: 10.3969/j.issn.1005-9202.2020.14.014.
    [32]
    安然, 孙迎春,高平. 富白细胞血小板纤维蛋白与富血小板血浆对比[J]. 河北医药, 2013, 35(20): 3148-3150. DOI: 10.3969/j.issn.1002-7386.2013.20.062.
    [33]
    董希杰. 富血小板纤维蛋白在慢性伤口治疗中的应用研究进展[J]. 湖北民族学院学报(医学版), 2018, 35(1): 60-62,66. DOI: 10.13501/j.cnki.42-1590/r.2018.01.019.
    [34]
    CrisciA,MarottaG,LicitoA,et al.Use of leukocyte platelet (L-PRF) rich fibrin in diabetic foot ulcer with osteomyelitis (three clinical cases report)[J].Diseases,2018,6(2):30.DOI: 10.3390/diseases6020030.
    [35]
    AndreoneA,den HollanderD.A retrospective study on the use of dermis micrografts in platelet-rich fibrin for the resurfacing of massive and chronic full-thickness burns[J].Stem Cells Int,2019,2019:8636079.DOI: 10.1155/2019/8636079.
    [36]
    邓波, 江波, 陈静文,等. 自体富血小板纤维蛋白治疗慢性伤口有效性与安全性的Meta分析[J]. 护理学报, 2019, 26(13): 6-11. DOI: 10.16460/j.issn1008-9969.2019.13.006.
    [37]
    张彬柱,刘刚,龚慧,等.应用富血小板纤维蛋白治疗静脉曲张溃疡效果研究[J].创伤与急危重病医学,2019,7(6):383-385.DOI: 10.16048/j.issn.2095-5561.2019.06.16.
    [38]
    吴晶洋,白艳洁,王稚英.富血小板纤维蛋白和浓缩生长因子对施万细胞影响的比较[J].中国医科大学学报,2016,45(12):1089-1093.DOI: 10.12007/j.issn.0258-4646.2016.12.008.
    [39]
    XuFF,QiaoL,ZhaoYM,et al.The potential application of concentrated growth factor in pulp regeneration: an in vitro and in vivo study[J].Stem Cell Res Ther,2019,10(1):134.DOI: 10.1186/s13287-019-1247-4.
    [40]
    LiXJ,YangHX,ZhangZJ,et al.Concentrated growth factor exudate enhances the proliferation of human periodontal ligament cells in the presence of TNF-α[J].Mol Med Rep,2019,19(2):943-950.DOI: 10.3892/mmr.2018.9714.
    [41]
    杨景军, 陈航, 魏子人,等. 自体富血小板凝胶在老年烧伤患者整复治疗中对创面愈合及肉芽组织特异性蛋白表达的影响[J]. 中国美容医学, 2019, 28(12): 83-87. DOI: 10.15909/j.cnki.cn61-1347/r.003430.
    [42]
    ChenX,WangJ,YuL,et al.Effect of concentrated growth factor (CGF) on the promotion of osteogenesis in bone marrow stromal cells (BMSC) in vivo[J].Sci Rep,2018,8(1):5876.DOI: 10.1038/s41598-018-24364-5.
    [43]
    YuM,WangXJ,LiuY,et al.Cytokine release kinetics of concentrated growth factors in different scaffolds[J].Clin Oral Investig,2019,23(4):1663-1671.DOI: 10.1007/s00784-018-2582-z.
    [44]
    KizilaslanS,KarabudaZC,OlgacV.The effect of concentrated growth factor on calvarial bone in diabetic healing[J].J Craniofac Surg,2020,31(1):158-161.DOI: 10.1097/SCS.0000000000006087.
    [45]
    汪淼, 赵启明, 陆海山,等. CGF在多种类型创面修复中的临床应用[J]. 中国美容医学, 2020, 29(4): 75-78. DOI: 10.15909/j.cnki.cn61-1347/r.003533.
    [46]
    KaoCH.Use of concentrate growth factors gel or membrane in chronic wound healing: description of 18 cases[J].Int Wound J,2020,17(1):158-166.DOI: 10.1111/iwj.13250.
    [47]
    ParkHC,KimSG,OhJS,et al.Early bone formation at a femur defect using CGF and PRF grafts in adult dogs: a comparative study[J].Implant Dent,2016,25(3):387-393.DOI: 10.1097/ID.0000000000000423.
    [48]
    KimTH,KimSH,SándorGK,et al.Comparison of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) in rabbit-skull defect healing[J].Arch Oral Biol,2014,59(5):550-558.DOI: 10.1016/j.archoralbio.2014.02.004.
    [49]
    GhufranH,MehmoodA,AzamM,et al.Curcumin preconditioned human adipose derived stem cells co-transplanted with platelet rich plasma improve wound healing in diabetic rats[J].Life Sci,2020,257:118091.DOI: 10.1016/j.lfs.2020.118091.
    [50]
    QiaoSC, ShenQB, LiZH, et al. 3D-printed Ti6Al4V scaffolds coated with freeze-dried platelet-rich plasma as bioactive interface for enhancing osseointegration in osteoporosis[J]. Materials & Desingn, 2020,194: 108825. DOI: 10.1016/j.matdes.2020.108825.
    [51]
    王献利,王国庆,冯艳川,等.钛网联合浓缩生长因子在上前牙即刻种植中的短期临床效果观察[J].口腔颌面修复学杂志,2020,21(1):12-16.DOI: 10.19748/j.cn.kqxf.1009-3761.2020.01.003.
    [52]
    李艳玲,郝岱峰,崔正军.富血小板血浆凝胶联合负压封闭引流治疗患者心脏术后正中切口不愈合的疗效[J].中华烧伤杂志,2017,33(10):619-622.DOI: 10.3760/cma.j.issn.1009-2587.2017.10.007.
    [53]
    刘刚, 王杨, 左娜,等. 负压封闭引流技术联合富血小板纤维蛋白修复巨大皮肤脓肿清创后难愈性创面[J]. 中国美容医学, 2019, 28(12): 1-3. DOI: 10.15909/j.cnki.cn61-1347/r.003403.
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