含有序微纳米结构的生物材料用于创面修复的研究进展

陶怡冰; 施可庆; 肖健

doi:10.3760/cma.j.cn501225-20221017-00455

含有序微纳米结构的生物材料用于创面修复的研究进展

doi: 10.3760/cma.j.cn501225-20221017-00455

温州医科大学附属第一医院创面修复与再生中心，转化医学实验室，温州　　325000

基金项目:

中国高校产学研创新基金 2021JH041

温州医科大学基本科研业务费立项项目重点项目 KYYW202108

详细信息

通讯作者:
肖健，Email：xfxj2000@126.com

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- 文章访问数: 161
- HTML全文浏览量: 24
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- 被引次数: 0
出版历程
- 收稿日期: 2022-10-17

Research progress of biomaterials with ordered micro-nano structure in wound repair

Laboratory of Translational Medicine, Wound Repair and Regeneration Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China

Funds:

Industry-University-Research Inno-vation Fund for Chinese Universities 2021JH041

Approved Key Project of Basic Scientific Research Fund of Wenzhou Medical University KYYW202108

More Information

Corresponding author: Xiao Jian, Email: xfxj2000@126.com

摘要

摘要: 许多致伤因素，包括烧伤、手术等均可能导致皮肤结构和功能的破坏，合适的创面敷料或植入物是促进创面愈合与再生的物质基础。含微纳米结构的生物材料能够影响细胞行为，促进细胞顺应结构进行有序生长，将该类材料应用于创面修复中可促进血管新生、调节免疫反应、减少瘢痕面积。近年来，含有序微纳米结构的生物材料在组织工程中的应用得到了广泛关注。该文介绍了几种含有序微纳米结构的生物材料的结构和制备方法，并重点讨论了生物材料表面微结构如何影响创面愈合及其分子机制，以期为临床上创面的治疗寻找和研制更贴近皮肤组织结构的医学生物材料。
- 伤口愈合 /
- 组织工程 /
- 纳米纤维 /
- 生物相容性材料 /
- 沟槽 /
- 微纳米结构
Abstract: Many injury-causing factors, including burns and surgery, etc., can lead to the destruction of structure and function of skin. Suitable wound dressing or implant is the material basis to promote wound healing and regeneration. Biomaterials with micro-nano structure can affect cell behavior, promote orderly growth of cell in accordance with the structure. Their application in wound healing can promote angiogenesis, regulate immune response, and reduce scar area. In recent years, the application of biomaterials with ordered micro-nano structure in tissue engineering has attracted extensive attention. This paper introduces the structure and preparation methods of several biomaterials with ordered micro-nano structure, and focuses on how the surface microstructure of biomaterials affects the process of wound healing and its molecular mechanism, in order to find and develop medical biomaterials that are closer to the skin tissue structure for clinical wound treatment.
- Wound healing /
- Tissue engineering /
- Nanofibers /
- Biocompatible materials /
- Groove /
- Micro-nano structure
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