重组人胶原蛋白生物材料在组织工程领域的应用研究进展

柳欢; 奥布力阿西木·牙库普; 金荣华; 张惟; 韩春茂; 王新刚

doi:10.3760/cma.j.cn501225-20240229-00081

重组人胶原蛋白生物材料在组织工程领域的应用研究进展

doi: 10.3760/cma.j.cn501225-20240229-00081

1.
浙江大学医学院附属第二医院烧伤与创面修复科,杭州　　310009
2.
浙江大学医学院附属第二医院整形外科,杭州　　310009

基金项目:

国家重点研发计划 2022YFC2403100

国家自然科学基金面上项目 81772069

详细信息

通讯作者:
王新刚,Email：wangxingang8157@zju.edu.cn

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出版历程
- 收稿日期: 2024-02-29
- 网络出版日期: 2025-02-25

Research advances on the application of recombinant human collagen biomaterials in the field of tissue engineering

1.
Department of Burns and Wound Repair, the Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou 310009, China
2.
Department of Plastic Surgery, the Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou 310009, China

Funds:

National Key Research and Development Program of China 2022YFC2403100

General Program of National Natural Science Foundation of China 81772069

More Information

Corresponding author: Wang Xingang, Email: wangxingang8157@zju.edu.cn

摘要

摘要: 重大创烧伤等引起的大面积组织和器官缺损是临床上常见的问题。重组人胶原蛋白生物材料具有生物相容性良好、可定制化、氨基酸序列稳定、免疫原性低以及可生物降解等诸多优点,被广泛用于组织工程领域,具有广阔的临床应用前景。该文简要总结了重组人胶原蛋白生物材料的设计与制备方式、加工技术及其在组织工程领域的应用情况及最新研究进展。
- 生物相容性材料 /
- 组织支架 /
- 再生 /
- 重组蛋白质类 /
- 重组人胶原蛋白
Abstract: Extensive tissue and organ defects caused by major trauma and burns are common problems in clinical practice. Recombinant human collagen biomaterials, with advantages including impeccable biocompatibility, customization, stable amino acid sequence, low immunogenicity, and inherent biodegradation, have been widely used in the field of tissue engineering and have broad clinical application prospects. This paper briefly summarizes the design and preparation methods, processing techniques of recombinant human collagen biomaterials and their application in the field of tissue engineering, as well as the latest research advances.
- Biocompatible materials /
- Tissue scaffolds /
- Regeneration /
- Recombinant proteins /
- Recombinant human collagen
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参考文献(51)

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Table 1. 重组人胶原蛋白生物材料的改性技术及其目的

技术	具体方法	目的
化学技术	使用交联剂,如1-乙基-3-（3-二甲基氨基丙基）碳二亚胺、N-羟基琥珀酰亚胺和1-乙基-3-（3-二甲基氨基丙基）碳二亚胺；甲基丙烯酸酐化	增强稳定性、改善生物降解性、增强机械强度和韧性、增加功能性（促进组织再生性能和创面愈合性能等）、增加活性结合位点
物理技术	紫外线照射、冷冻-干燥技术、三维生物打印技术、生物涂层技术等	目的同化学技术
材料复合技术	重组胶原复合壳聚糖、重组胶原复合甲基丙烯酸酐化明胶、重组胶原复合聚氧化乙烯等	目的同化学技术
生物技术	优化发酵、酶处理等	提高生物相容性、降低抗原性、定制化应用