皮肤类器官在创面修复中的应用研究进展

赵思远; 李伟; 孔维诗; 关丁丁; 孙瑜

doi:10.3760/cma.j.cn501225-20240901-00323

皮肤类器官在创面修复中的应用研究进展

doi: 10.3760/cma.j.cn501225-20240901-00323

海军军医大学第一附属医院烧创伤与创面修复科, 全军烧伤研究所, 中国医学科学院烧伤暨烧创复合伤救治关键技术创新单元, 上海 200433

基金项目:

上海市卫生健康委员会科研项目 20244Z0009

详细信息

通讯作者:
孙瑜, Email：littlefish0916@126.com

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- 被引次数: 0
出版历程
- 收稿日期: 2024-09-01

Research advances on the application of skin organoids in wound repair

Burn Institute of PLA, Department of Burn Trauma and Wound Repair, the First Affiliated Hospital of Naval Medical University, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, Shanghai 200433, China

Funds:

Scientific and Research Program of Shanghai Municipal Health Commission 20244Z0009

More Information

Corresponding author: Sun Yu, Email: littlefish0916@126.com

摘要

摘要: 皮肤是一种具有复杂结构和功能的器官。大面积皮肤缺损和慢性难愈性创面给患者和临床工作者带来严重困扰, 传统修复方法尚未能实现皮肤结构与功能的完全重建。如何实现皮肤结构与功能的完全重建是创面修复领域亟待解决的难题。诱导多能干细胞因具有分化成为任何人体细胞的潜能, 被广泛应用于再生医学研究中。近年来, 通过干细胞体外培养构建的皮肤类器官, 不仅包含表皮、真皮, 还具有多种皮肤附属器, 这一技术突破了传统皮肤替代物的限制, 为创面修复及其基础研究开辟了新路径。该文系统概述了皮肤类器官的研究与应用现状, 并讨论了目前其在临床转化中所面临的挑战以及发展前景。
- 皮肤 /
- 类器官 /
- 组织工程 /
- 再生医学 /
- 皮肤附属器 /
- 创面修复
Abstract: Skin is an organ with complex structure and function. Extensive skin defects and chronic non-healing wounds cause serious problems for patients and clinicians, while traditional repair methods are still not able to completely reconstruct the structure and function of skin. To achieve complete reconstruction of skin structure and function is a great challenge that needs to be solved in the field of wound repair. Induced pluripotent stem cells, which have the potential to differentiate into any human cells, are widely used in the field of regenerative medicine research. In recent years, skin organoids constructed through in vitro cultivation of stem cells contain epidermis, dermis, and multiple skin appendages, which overcomes the limitations of traditional skin substitute and opens new avenues for wound repair and its basic research. This review outlines the status of the research and application of skin organoids and discusses their current challenges in clinical translation and prospects for development.
- Skin /
- Organoids /
- Tissue engineering /
- Regenerative medicine /
- Skin appendage /
- Wound repair
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