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摘要: 糖尿病足溃疡（DFU）是糖尿病患者常见且难以治愈的并发症。在DFU的发生和发展过程中,患者体内能量代谢障碍会导致血管神经病变等一系列问题,通过拟缺氧、氧化应激与慢性炎症反应,导致免疫与修复细胞的代谢重编程和功能失衡,最终造成溃疡形成与创面愈合延迟。该文总结了DFU患者常见能源物质代谢障碍与DFU发生和发展的内在联系,能量代谢障碍对DFU创面细胞的影响,以及靶向能量代谢治疗DFU的基础和临床研究进展。Abstract: Diabetic foot ulcer (DFU) represents a common and difficult-to-treat complication in diabetic patients. During the initiation and progression of DFU, the impaired energy metabolism in patients leads to a spectrum of pathological processes, including vasculopathy and neuropathy. Through pseudo-hypoxia, oxidative stress, and chronic inflammation, the energy metabolism disorders can result in metabolic reprogramming and functional dysregulation of immune and reparative cells, ultimately leading to ulcer formation and delayed wound healing. This review summarized the intrinsic relationship between common energy substance metabolism disorders in DFU patients and the onset and progression of DFU, the impact of energy metabolism disorders on wound cells in DFU, as well as the foundational and clinical research progress on targeted energy metabolism therapy for DFU.
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Key words:
- Diabetic foot /
- Foot ulcer /
- Energy metabolism /
- Metabolism disorders /
- Signaling pathway
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参考文献
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