外泌体多组学分析技术在烧伤脓毒症预警与诊断中应用的研究进展

陈宇曦; 罗亮; 蒋诗情; 王耘川; 胡大海

doi:10.3760/cma.j.cn501225-20250512-00222

外泌体多组学分析技术在烧伤脓毒症预警与诊断中应用的研究进展

doi: 10.3760/cma.j.cn501225-20250512-00222

空军军医大学第一附属医院全军烧伤中心, 烧伤与皮肤外科, 西安 710032

基金项目:

国家自然科学基金重点项目 81530064

陕西省重点研发计划项目 2023-ZDLSF-24

详细信息

通讯作者:
胡大海, Email：hudahai@fmmu.edu.cn

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- 文章访问数: 163
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- 被引次数: 0
出版历程
- 收稿日期: 2025-05-12

Research advances on the application of exosomal multi-omics analysis technology in warning and diagnosis of burn sepsis

Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China

Funds:

Key Program of National Natural Science Foundation of China 81530064

Shaanxi Provincial Key Research and Development Program of China 2023-ZDLSF-24

More Information

Corresponding author: Hu Dahai, Email: hudahai@fmmu.edu.cn

摘要

摘要: 作为导致烧伤患者死亡的主要原因之一, 脓毒症的早期预警与诊断面临挑战, 这主要源于其非特异性临床表现和传统生物标志物检测效能的局限性。作为细胞间信息传递的重要载体, 外泌体及其内含物（RNA、蛋白质、代谢物）可反映机体病理生理状态, 在疾病诊断领域备受关注。该文旨在综述外泌体多组学（转录组学、蛋白质组学、代谢组学等）分析技术在烧伤脓毒症预警和诊断中应用的研究进展, 探讨其在揭示疾病机制、筛选特异性早期生物标志物及结合新兴生物信息学技术方面的应用潜力, 以期为实现烧伤脓毒症的精准诊断和治疗提供新的策略和方向。
- 烧伤 /
- 脓毒症 /
- 外泌体 /
- 诊断 /
- 系统生物学 /
- 生物标志物
Abstract: As one of the primary causes of death in burn patients, sepsis presents challenges in early warning and diagnosis, mainly due to its nonspecific clinical manifestations and the limitations of traditional biomarker detection efficiency. As an important carrier of intercellular information transfer, exosomes and their contents (RNAs, proteins, and metabolites) can reflect the pathophysiological status of the body, thus attracting significant attention in the field of disease diagnosis. This review aims to summarize the research advances of exosomal multi-omics (transcriptomics, proteomics, metabolomics, etc.) analysis technologies in the warning and diagnosis of burn sepsis, and explore their application potential in revealing disease mechanisms, screening specific early biomarkers, and integrating emerging bioinformatics technologies. The goal is to provide new strategies and directions for achieving the precision diagnosis and treatment of burn sepsis.
- Burns /
- Sepsis /
- Exosomes /
- Diagnosis /
- Systems biology /
- Biomarkers
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