皮肤附属器类器官在创面修复中的应用研究进展

王苗苗; 何雨桐; 解巧利; 周伟; 向霄; 雷明星

doi:10.3760/cma.j.cn501225-20260228-00092

皮肤附属器类器官在创面修复中的应用研究进展

doi: 10.3760/cma.j.cn501225-20260228-00092

1.
生物流变科学与技术教育部重点实验室,重庆大学生物工程学院,重庆　400045
2.
重庆大学附属肿瘤医院肿瘤放射治疗中心,重庆　400030

基金项目:

国家重点研发计划 2023YFC2508200

国家自然科学基金面上项目 82373509, 82574005

国家自然科学外国青年学者研究基金项目 W2533206

国家自然科学基金青年科学基金项目 82504319

重庆市自然科学基金面上项目 CSTB2023NSCQ-MSX0866

中央高校基本科研业务费项目 2024CDJQYJCYJ-001

详细信息

通讯作者:
雷明星,Email：mingxing@cqu.edu.cn

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出版历程
- 收稿日期: 2026-02-28
- 网络出版日期: 2026-06-18

Research advances on the application of skin appendage organoids in wound repair

1.
Key Laboratory of Biorheological Science and Technology of Ministry of Education111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing 400045, China
2.
Department of Radiation Oncology, Chongqing University Cancer Hospital, Chongqing 400030, China

Funds:

National Key Research and Development Program of China 2023YFC2508200

General Program of National Natural Science Foundation of China 82373509, 82574005

National Natural Science Foundation of China Research Fund for International Young Scientists W2533206

Youth Science Foundation Project of National Natural Science Foundation of China 82504319

General Program of Natural Science Foundation of Chongqing CSTB2023NSCQ-MSX0866

Fundamental Research Funds for the Central Universities 2024CDJQYJCYJ-001

More Information

Corresponding author: Lei Mingxing, Email: mingxing@cqu.edu.cn

摘要

摘要: 皮肤创面常伴随毛囊、汗腺等附属器的结构破坏与功能丧失,传统修复方法难以实现皮肤结构与功能的完整重建。皮肤类器官技术的发展为突破这一瓶颈提供了新途径。该文在回顾皮肤类器官发展历程的基础上,系统阐述了皮肤附属器类器官在促进皮肤功能性再生方面的策略与应用,分析了血管与神经的整合对提升创面修复质量的关键作用。最后,该文总结当前干细胞诱导、三维生物打印、微流控、器官芯片及空气-液体界面培养等技术面临的挑战,并展望皮肤附属器类器官的临床转化前景。
- 皮肤 /
- 类器官 /
- 器官培养技术 /
- 毛囊 /
- 汗腺 /
- 皮肤附属器 /
- 组织再生 /
- 创面修复
Abstract: Skin wounds are often accompanied by structural damage and functional loss of appendages such as hair follicles and sweat glands, which cannot be fully restored by conventional repair methods. The development of skin organoid technology provides a new avenue to overcome this bottleneck. This article reviews the developmental history of skin organoids and systematically elaborates on the strategies and applications of skin appendage organoids in promoting functional skin regeneration. Furthermore, it analyzes the critical role of vascular and neural integration in improving the quality of wound repair. Finally, the article summarizes the current challenges associated with technologies such as stem cell induction, three-dimensional bioprinting, microfluidics, organ-on-a-chip, and air-liquid interface culture, and provides perspectives on the clinical translation of skin appendage organoids.
- Skin /
- Organoids /
- Organoid culture techniques /
- Hair follicle /
- Sweat glands /
- Skin appendages /
- Tissue regeneration /
- Wound repair
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