Research advances on the role and mechanism of inflammatory response in the formation of hypertrophic scars and keloids

Wang Hongtao; Han Juntao; Hu Dahai

doi:10.3760/cma.j.cn501120-20200310-00143

Volume 37 Issue 5

May 2021

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Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2021 > 37(5): 490-494

Wang Hongtao, Han Juntao, Hu Dahai. Research advances on the role and mechanism of inflammatory response in the formation of hypertrophic scars and keloids[J]. Chin j Burns, 2021, 37(5): 490-494. DOI: 10.3760/cma.j.cn501120-20200310-00143

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Research advances on the role and mechanism of inflammatory response in the formation of hypertrophic scars and keloids

doi: 10.3760/cma.j.cn501120-20200310-00143

Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China

Received Date: 2020-03-10
Available Online: 2021-10-28
Publish Date: 2021-05-20

Abstract

Abstract

Hypertrophic scars and keloids are common sequelae after wound healing, with a high incidence, which seriously affect the patient's quality of life. However, there is still a lack of effective prevention and treatment methods, mainly because the pathogenesis of scars is not clear. Current research believe that inflammatory response plays a critical role in the process of scar formation, and through the researches on the mechanisms it is hopeful to find new potential therapeutic drug targets for the prevention and treatment of hypertrophic scars and keloids. This article mainly reviews the research progresses on the role and mechanism of inflammatory cytokines and inflammatory cells in the formation of hypertrophic scars and keloids, as well as drugs, microRNAs, and exosomes, etc., for the treatment of hypertrophic scars and keloids by inhibiting inflammatory response.
- Keloid,
- Inflammation,
- Hypertrophic scar,
- Inflammatory cell,
- Inflammatory cytokine

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Research advances on the role and mechanism of inflammatory response in the formation of hypertrophic scars and keloids

doi: 10.3760/cma.j.cn501120-20200310-00143

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Research advances on the role and mechanism of inflammatory response in the formation of hypertrophic scars and keloids

doi: 10.3760/cma.j.cn501120-20200310-00143

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