Current Issue

2025, Volume 41,  Issue 3

Expert Forum
Cleansing skin wound by irrigation with tap water replacing normal saline
Luo Gaoxing, Zhan Rixing, Yuan Zhiqiang, Song Huapei, Xiang Fei, Ma Siyuan, Li Haisheng, Qian Wei, Tan Jianglin, Peng Yizhi
2025, 41(3): 201-205. doi: 10.3760/cma.j.cn501225-20250108-00015
Abstract:
Wound cleansing is an essential step in skin wound management. It can prevent local infection and optimize healing micro-environment by removing necrotic tissue and foreign matter, reducing microbial load, breaking bacterial biofilm formation and so on. Many randomized controlled trials and meta-ana...
New strategy for sepsis treatment based on nanobiomaterial technology
Yao Yongming, Zhang Hui, Dong Ning
2025, 41(3): 206-211. doi: 10.3760/cma.j.cn501225-20241122-00458
Abstract:
The pathophysiological mechanisms underlying sepsis is complex, mainly involving excessive inflammatory response and immune dysfunction. The development of nanobiomaterial technology has brought brand-new options for the treatment of sepsis. In the current paper, we discuss the current application s...
Original Article·Research on Sepsis and its Mechanism
Effects of thioredoxin reductase 1 on ferroptosis and immune function of dendritic cells in septic mice
Zhou Qiyuan, Li Jingyan, Cao Yanmin, Li Weiling, Dong Ning, Wu Yao, Tian Yingping, Yao Yongming
2025, 41(3): 212-221. doi: 10.3760/cma.j.cn501225-20241118-00451
Abstract:
Objective To investigate the effects of thioredoxin reductase 1 (TXNRD1) on ferroptosis and immune function of dendritic cells (DCs) in septic mice, and to provide a basis for improving the immunosuppression in sepsis caused by wound infection. Methods This study was an experimental research. Sixty ...
Comparison of the Phoenix scoring system and commonly used pediatric sepsis scores in predicting mortality risk in pediatric patients with severe sepsis under traditional standards
Wang Haonan, He Yinglang, Tan Rui, Li Han, Li Xian, Hou Nan, Ji Chen, Li Zhe, Wang Yue, Peng Shuangshuang, Jing Le, Gu Liye, Zhao Junjie, Miao Hongjun
2025, 41(3): 222-231. doi: 10.3760/cma.j.cn501225-20240613-00229
Abstract:
Objective To explore the differences between the Phoenix sepsis scoring system including Phoenix sepsis score (PSS) and Phoenix-8 organ dysfunction score (hereinafter referred to as Phoenix-8) and the commonly used pediatric sepsis scores in evaluating clinical characteristics and prognostic analysi...
Original Article
Application strategies and clinical effects of superior gluteal artery perforator tissue flaps in repairing stage Ⅳ pressure ulcers in the sacrococcygeal region
Deng Rufei, Fan Baowen, Song Songhua, Long Luyao, Chen Yanwei, Chen Jiaxin, Ji Ruchen, Zhang Yonghong, Hu Xiangtian, Huang Guoneng, Jiang Zhenyu, Jiang Lan, Zou Lijin, Xin Guohua, Zeng Yuanlin, Zhang Youlai
2025, 41(3): 232-241. doi: 10.3760/cma.j.cn501225-20240804-00294
Abstract:
Objective To explore the application strategies and clinical effects of superior gluteal artery perforator tissue flaps in repairing stage Ⅳ pressure ulcers in the sacrococcygeal region. Methods This study was a retrospective observational study. From July 2019 to April 2024, 89 patients with stage ...
Clinical effects of sequential treatment of extensive skin and soft tissue injuries of the lower leg accompanied by large segmental tibial defects by free transplantation of anterolateral thigh perforator flap combined with bone transport
Zhao Hailei, Sun Zhigang, Zhao Xiaohui, Yang Bin, Shi Ming, Shen Yuming
2025, 41(3): 242-250. doi: 10.3760/cma.j.cn501225-20240926-00350
Abstract:
Objective To explore the clinical effects of sequential treatment of extensive skin and soft tissue injuries of the lower leg accompanied by large segmental tibial defects by free transplantation of anterolateral thigh perforator flap combined with bone transport. Methods This study was a retrospect...
Clinical effects of lobulated supercharged pedicled rectus abdominis myocutaneous flap for repairing huge chest wall wounds
Zhang Xinshan, Yu Junyi, Li Zan, Song Dajiang
2025, 41(3): 251-257. doi: 10.3760/cma.j.cn501225-20240109-00012
Abstract:
Objective To explore the clinical effects of lobulated supercharged pedicled rectus abdominis myocutaneous flap for repairing huge chest wall wounds. Methods This study was a retrospective observational study. From January 2020 to June 2023, 9 patients with huge chest wall wounds remained after exte...
Influence and mechanism of extracellular vesicles derived from human adipose-derived mesenchymal stem cells on pyroptosis of human umbilical vein endothelial cells induced by high glucose
Feng Junyun, Fei Xiao, Fang Shaoyihan, An Jingwen, Shi Yan, Liu Dewu
2025, 41(3): 258-267. doi: 10.3760/cma.j.cn501225-20240120-00025
Abstract:
Objective To investigate the influence and mechanism of extracellular vesicles (EVs) derived from human adipose-derived mesenchymal stem cells (hADMSCs), i.e. hADMSC-EVs on pyroptosis of human umbilical vein endothelial cells (HUVECs) induced by high glucose, with the aim of providing evidence for i...
Effects and mechanism of metformin on the proliferation and expression of fibrotic proteins of human hypertrophic scar fibroblasts
Xie Wenbo, Hu Xiaolong, Wei Shuang, Shi Jihong
2025, 41(3): 268-276. doi: 10.3760/cma.j.cn501225-20231220-00259
Abstract:
Objective To investigate the effects and mechanism of metformin on the proliferation and expression of fibrotic proteins of human hypertrophic scar (HS) fibroblasts (Fbs). Methods The study was an experimental study. From June 2021 to June 2022, 5 patients with HS were admitted to the Department of ...
Effects of baicalin on ferroptosis of mouse fibroblasts under high glucose treatment and its mechanism
Gong Zheng, Zhang Xiaowei, Li Xiaomei, Yin Zhimin, Bai Limin, Wang Jiaxi, Han Yujia, Xu Shuangyi, Yu Lu, Xu Gang
2025, 41(3): 277-285. doi: 10.3760/cma.j.cn501225-20240425-00151
Abstract:
Objective To investigate the effects of baicalin on ferroptosis of mouse fibroblasts (Fbs) under high glucose treatment and its mechanism, and to provide a basis for the treatment of diabetic wounds. Methods The study was an experimental study. Mouse Fbs were collected and divided into control group...
Influence of human induced pluripotent stem cell derived skin organoid-conditioned culture medium on the function of human dermal fibroblasts induced by high glucose
Liu Zhixin, Qiu Kaizhen, He Jia, Wang Jingru, Liu Bilai, Xin Qi, Li Guiqiang, Chen Xiaodong
2025, 41(3): 286-294. doi: 10.3760/cma.j.cn501225-20241020-00404
Abstract:
Objective To explore the influence of human induced pluripotent stem cell (iPSC) derived skin organoid-conditioned culture medium (SO-CM) on the function of human dermal fibroblasts (Fbs) induced by high glucose, with the aim of providing treatment ideas for diabetic wounds. Methods This study was a...
Review
Research advances on hydrogels for promoting wound vascularization
Shi Ao, Wang Yunwei, Kang Yuchen, Wang Gang, Liu Yi
2025, 41(3): 295-300. doi: 10.3760/cma.j.cn501225-20240521-00193
Abstract:
High glucose-induced vascular endothelial cell injury serves as a primary pathological factor contributing to delayed healing of diabetic wounds. Effective wound vascularization remains a core challenge in tissue engineering research. Hydrogel-based injectable technology and three-dimensional (3D) b...