Volume 37 Issue 9
Sep.  2021
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Chen Z,He X,Yao MW,et al.Research advances on the cholinergic inflammatory reflex and inflammation resolution[J].Chin J Burns,2021,37(9):885-889.DOI: 10.3760/cma.j.cn501120-20200609-00299.
Citation: Chen Z,He X,Yao MW,et al.Research advances on the cholinergic inflammatory reflex and inflammation resolution[J].Chin J Burns,2021,37(9):885-889.DOI: 10.3760/cma.j.cn501120-20200609-00299.

Research advances on the cholinergic inflammatory reflex and inflammation resolution

doi: 10.3760/cma.j.cn501120-20200609-00299
Funds:

Youth Science Foundation of National Natural Science Foundation of China 81801585

Emergency Special Project of 2019 Novel Coronavirus Infection and Prevention and Control of Chongqing Education Commission of China KYYJ202009

Military Pre-research Project of Army Medical University 2019XYY21

Youth Science Foundation of National Natural Science Foundation of China 81501666

More Information
  • The vagus nerve plays an important role in regulating the homeostasis of inflammation. Inflammation signals in the body are passed to the vagus nerve efferent fibers via nerve reflexes, and the signals generated by efferent fibers will play an anti-inflammatory role in various inflammatory diseases through immune cells such as T cells that express choline acetyltransferase and macrophages. However, the resolution of inflammation is not only the interaction between pro-inflammatory and anti-inflammatory cytokines, but also an active process of biosynthesis, including the synthesis of various pro-resolving mediators and their physiological utility process. Moreover, the cholinergic inflammation reflex also plays a crucial role in inflammation resolution. This review reviews and summarizes the cholinergic inflammatory reflex and its key role in the process of inflammation resolution.

     

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