Research advances on the cholinergic inflammatory reflex and inflammation resolution

Chen Zhuo; He Xiao; Yao Mengwei; Li Zhan; Xu Xiang

doi:10.3760/cma.j.cn501120-20200609-00299

Volume 37 Issue 9

Sep. 2021

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2021 > 37(9): 885-894

Chen Z,He X,Yao MW,et al.Research advances on the cholinergic inflammatory reflex and inflammation resolution[J].Chin J Burns,2021,37(9):885-889.DOI: 10.3760/cma.j.cn501120-20200609-00299.

Citation:

Chen Z,He X,Yao MW,et al.Research advances on the cholinergic inflammatory reflex and inflammation resolution[J].Chin J Burns,2021,37(9):885-889.DOI: 10.3760/cma.j.cn501120-20200609-00299.

Citation:

Chen Z,He X,Yao MW,et al.Research advances on the cholinergic inflammatory reflex and inflammation resolution[J].Chin J Burns,2021,37(9):885-889.DOI: 10.3760/cma.j.cn501120-20200609-00299.

PDF( 652 KB)

Research advances on the cholinergic inflammatory reflex and inflammation resolution

doi: 10.3760/cma.j.cn501120-20200609-00299

Chen Zhuo¹,
He Xiao²,
Yao Mengwei³,
Li Zhan³,
Xu Xiang^{3
,
,}

1.
Basic Medical School of Army Medical University (the Third Military Medical University), Chongqing 400038, China
2.
Rocket Force Characteristic Medical Center, Beijing 100088, China
3.
Department of Stem Cell and Regenerative Medicine, Army Medical Center of PLA, Chongqing 400042, China

Funds:

Youth Science Foundation of National Natural Science Foundation of China 81801585

Emergency Special Project of 2019 Novel Coronavirus Infection and Prevention and Control of Chongqing Education Commission of China KYYJ202009

Military Pre-research Project of Army Medical University 2019XYY21

Youth Science Foundation of National Natural Science Foundation of China 81501666

More Information

Corresponding author: Xu Xiang, Email: xiangxu@tmmu.edu.cn
Received Date: 2020-06-09

Abstract

Abstract

The vagus nerve plays an important role in regulating the homeostasis of inflammation. Inflammation signals in the body are passed to the vagus nerve efferent fibers via nerve reflexes, and the signals generated by efferent fibers will play an anti-inflammatory role in various inflammatory diseases through immune cells such as T cells that express choline acetyltransferase and macrophages. However, the resolution of inflammation is not only the interaction between pro-inflammatory and anti-inflammatory cytokines, but also an active process of biosynthesis, including the synthesis of various pro-resolving mediators and their physiological utility process. Moreover, the cholinergic inflammation reflex also plays a crucial role in inflammation resolution. This review reviews and summarizes the cholinergic inflammatory reflex and its key role in the process of inflammation resolution.
- Inflammation,
- Vagus nerve,
- Cholinergic inflammation reflex,
- Inflammation resolution,
- Specialized pro-resolving mediators

FullText(HTML)

References(19)

References

[1]	HongGS,ZillekensA,SchneikerB,et al.Non-invasive transcutaneous auricular vagus nerve stimulation prevents postoperative ileus and endotoxemia in mice[J].Neurogastroenterol Motil,2019,31(3):e13501.DOI: 10.1111/nmo.13501.
[2]	OkusaMD,RosinDL,TraceyKJ.Targeting neural reflex circuits in immunity to treat kidney disease[J].Nat Rev Nephrol,2017,13(11):669-680.DOI: 10.1038/nrneph.2017.132.
[3]	HolmesCJ,PlichtaJK,GamelliRL,et al.Burn injury alters epidermal cholinergic mediators and increases HMGB1 and caspase 3 in autologous donor skin and burn margin[J].Shock,2017,47(2):175-183.DOI: 10.1097/SHK.0000000000000752.
[4]	FullertonJN,GilroyDW.Resolution of inflammation: a new therapeutic frontier[J].Nat Rev Drug Discov,2016,15(8):551-567.DOI: 10.1038/nrd.2016.39.
[5]	BarnigC,BezemaT,CalderPC,et al.Activation of resolution pathways to prevent and fight chronic inflammation: lessons from asthma and inflammatory bowel disease[J].Front Immunol,2019,10:1699.DOI: 10.3389/fimmu.2019.01699.
[6]	MarquetteC,LinardC,GalonnierM,et al.IL-1β, TNFα and IL-6 induction in the rat brain after partial-body irradiation: role of vagal afferents[J].Int J Radiat Biol,2003,79(10):777-785.DOI: 10.1080/09553000310001610998.
[7]	GoehlerLE,GaykemaRP,NguyenKT,et al.Interleukin-1β in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems?[J].J Neurosci,1999,19(7):2799-2806.DOI: 10.1523/JNEUROSCI.19-07-02799.1999.
[8]	GaykemaRP,GoehlerLE,TildersFJ,et al.Bacterial endotoxin induces fos immunoreactivity in primary afferent neurons of the vagus nerve[J].Neuroimmunomodulation,1998,5(5):234-240.DOI: 10.1159/000026343.
[9]	MillsKH.TLR-dependent T cell activation in autoimmunity[J].Nat Rev Immunol,2011,11(12):807-822.DOI: 10.1038/nri3095.
[10]	FernándezR,NardocciG,SimonF,et al.Lipopolysaccharide signaling in the carotid chemoreceptor pathway of rats with sepsis syndrome[J].Respir Physiol Neurobiol,2011,175(3):336-348.DOI: 10.1016/j.resp.2010.12.014.
[11]	PavlovVA,OchaniM,Gallowitsch-PuertaM,et al.Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia[J].Proc Natl Acad Sci U S A,2006,103(13):5219-5223.DOI: 10.1073/pnas.0600506103.
[12]	InoueT,AbeC,SungSS,et al.Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes[J].J Clin Invest,2016,126(5):1939-1952.DOI: 10.1172/JCI83658.
[13]	LuB,KwanK,LevineYA,et al.α7 nicotinic acetylcholine receptor signaling inhibits inflammasome activation by preventing mitochondrial DNA release[J].Mol Med,2014,20(1):350-358.DOI: 10.2119/molmed.2013.00117.
[14]	Guzmán-MejíaF,López-RubalcavaC,González-EspinosaC.Stimulation of nAchRα7 receptor inhibits TNF synthesis and secretion in response to LPS treatment of mast cells by targeting ERK1/2 and TACE activation[J].J Neuroimmune Pharmacol,2018,13(1):39-52.DOI: 10.1007/s11481-017-9760-7.
[15]	MalinSG,ShavvaVS,TarnawskiL,et al.Functions of acetylcholine-producing lymphocytes in immunobiology[J].Curr Opin Neurobiol,2020,62:115-121.DOI: 10.1016/j.conb.2020.01.017.
[16]	VidaG,PeñaG,KanashiroA,et al.β2-Adrenoreceptors of regulatory lymphocytes are essential for vagal neuromodulation of the innate immune system[J].FASEB J,2011,25(12):4476-4485.DOI: 10.1096/fj.11-191007.
[17]	SerhanCN,SavillJ.Resolution of inflammation: the beginning programs the end[J].Nat Immunol,2005,6(12):1191-1197.DOI: 10.1038/ni1276.
[18]	JonesHR,RobbCT,PerrettiM,et al.The role of neutrophils in inflammation resolution[J].Semin Immunol,2016,28(2):137-145.DOI: 10.1016/j.smim.2016.03.007.
[19]	Greenlee-WackerMC.Clearance of apoptotic neutrophils and resolution of inflammation[J].Immunol Rev,2016,273(1):357-370.DOI: 10.1111/imr.12453.

Relative Articles

[1]	Chen Xuelian, Liu Yan. Research progresses on the role of programmed cell death in the inflammatory response of chronic refractory wounds[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2024, 40(10): 991-995. doi: 10.3760/cma.j.cn501225-20240123-00029
[2]	Wei Zairong, Zhang Yanji, Wang Dali. Roles of hypoxia and inflammation in wound healing[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2024, 40(6): 507-513. doi: 10.3760/cma.j.cn501225-20240111-00014
[3]	Shen Kuo, Wang Xujie, Liu Kaituo, Li Shaohui, Li Jin, Zhang Jinxin, Wang Hongtao, Hu Dahai. Effects of exosomes from human adipose-derived mesenchymal stem cells on inflammatory response of mouse RAW264.7 cells and wound healing of full-thickness skin defects in mice[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2022, 38(3): 215-226. doi: 10.3760/cma.j.cn501120-20201116-00477
[4]	Lei Ji'an, Zhou Yuan, Qin Zelian. Research advances on inflammatory responses involved in keloid development[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2021, 37(6): 591-595. doi: 10.3760/cma.j.cn501120-20200312-00154
[5]	Lou Jiaqi, Li Ye, Cui Qingwei, Zhang Pan, Sun Han, Tang Hao, Zhuang Mengmeng, Sun Yong. A prospectively randomized controlled study of the effects of intensive insulin therapy combined with glutamine on nutritional metabolism, inflammatory response, and hemodynamics in severe burn patients[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2021, 37(9): 821-830. doi: 10.3760/cma.j.cn501120-20210428-00159
[6]	Wang Hongtao, Han Juntao, Hu Dahai. Research advances on the role and mechanism of inflammatory response in the formation of hypertrophic scars and keloids[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2021, 37(5): 490-494. doi: 10.3760/cma.j.cn501120-20200310-00143
[7]	Gan Chunxia, Liu Mingzhuo, Liao Xincheng, Fu Zhonghua, Zeng Xiaoping, Wang Hongmei, Guo Guanghua. Role of 14-3-3σgene in the regulation of endotoxin/lipopolysaccharide-induced inflammatory responses in human pulmonary epithelial cells[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2020, 36(4): 260-266. doi: 10.3760/cma.j.cn501120-20191203-00450
[8]	Hao Yi, Yang Qinxin, Wang Qi, Xu Guangchao, Qi Fang, Deng Chengliang, Wei Zairong, Wang Dali. Research on feasibility of in vitro inflammatory wound microenvironment simulated by using inflammatory wound tissue homogenate of mice[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2020, 36(11): 1024-1034. doi: 10.3760/cma.j.cn501120-20200720-00351
[9]	Fang He, Xu Long, Zhu Feng. Advances in the research of persistent inflammation-immunosuppression-catabolism syndrome in severe burn[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2019, 35(7): 548-551. doi: 10.3760/cma.j.issn.1009-2587.2019.07.015
[10]	Ren Chao, Li Xiuhua, Wu Yao, Dong Ning, Yao Yongming. Influence of vagus nerve on multiple organ function and immune reaction of T lymphocytes in septic rats[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2018, 34(11): 815-820. doi: 10.3760/cma.j.issn.1009-2587.2018.11.018
[11]	Li Hushan, Yang Xuekang, Hao Zhenming, Lei Jin. Interventional effects of BAY11-7082 on lung inflammatory response at the early stage and acute lung injury of rats with severe burns[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2018, 34(2): 88-95. doi: 10.3760/cma.j.issn.1009-2587.2018.02.006
[13]	Zhang Fang, Li Jiahui, Xia Zhaofan. Inflammasome and its role in immunological and inflammatory response at early stage of burns[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2014, 30(3): 261-264. doi: 10.3760/cma.j.issn.1009-2587.2014.03.018
[14]	JIANG Qiong, WU Bo-yu, CHEN Xiao-dong. Effect of oleic acid on the proliferation and secretion of pro-inflammatory mediators of human nor- mal fibroblasts and scar fibroblasts[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2012, 28(6): 444-450. doi: 10.3760/cma.j.issn.1009-2587.2012.06.015
[16]	HUANG Jian, ZHANG Nian-chun, ZHOU Jian, YANG Zhi-huan. Effects of stimulation of intact vagus nerve on systemic inflammatory response in rats[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2008, 24(2): 99-101.

Supplements(0)

Cited By

Cited by
Periodical cited type(0)
Other cited types(1)

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(2)

Get Citation

PDF

XML

Article Metrics

Article views (286) PDF downloads(15)

Research advances on the cholinergic inflammatory reflex and inflammation resolution

doi: 10.3760/cma.j.cn501120-20200609-00299

Abstract

References

Relative Articles

Cited by

Periodical cited type(0)

Other cited types(1)

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Research advances on the cholinergic inflammatory reflex and inflammation resolution

doi: 10.3760/cma.j.cn501120-20200609-00299

Abstract

References

Relative Articles

Cited by

Periodical cited type(0)

Other cited types(1)

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content