Research advances on thymosin <b>β</b>4 in promoting wound healing

Gao Yixuan; Wang Lingfeng; Ba Te; Cao Shengjun; Li Junliang; Li Fang; Zhou Biao

doi:10.3760/cma.j.cn501120-20210221-00059

Volume 38 Issue 4

Apr. 2022

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Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2022 > 38(4): 378-384

Gao YX,Wang LF,Ba T,et al.Research advances on thymosin β4 in promoting wound healing[J].Chin J Burns Wounds,2022,38(4):378-384.DOI: 10.3760/cma.j.cn501120-20210221-00059.

Citation:

Gao YX,Wang LF,Ba T,et al.Research advances on thymosin β4 in promoting wound healing[J].Chin J Burns Wounds,2022,38(4):378-384.DOI: 10.3760/cma.j.cn501120-20210221-00059.

Citation:

Gao YX,Wang LF,Ba T,et al.Research advances on thymosin β4 in promoting wound healing[J].Chin J Burns Wounds,2022,38(4):378-384.DOI: 10.3760/cma.j.cn501120-20210221-00059.

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Research advances on thymosin β4 in promoting wound healing

doi: 10.3760/cma.j.cn501120-20210221-00059

1.
Department of Burns, the Third Affiliated Hospital of Inner Mongolia Medical University, Baotou 014010, China
2.
Burn Medical Institute of Inner Mongolia Autonomous Region, Baotou 014010, China

Funds:

Regional Science Foundation Project of National Natural Science Foundation of China 81660318

Science and Technology Plan of Baotou City 2019P3038

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Corresponding author: Wang Lingfeng, Email: wlf7413@vip.sina.com
Received Date: 2021-02-21

Abstract

Abstract

With the aging of population and the development of social economy, the incidence of chronic wounds is increasing day by day, while the incidence of burns and trauma remains at a high level, making wound repair an increasingly concerned area in clinical practice. Thymosin β4 is a naturally occurring small molecule protein in vivo, which is widely distributed in a variety of body fluids and cells, especially in platelets. Thymosin β4 has biological activities of promoting angiogenesis, anti-inflammation, anti-apoptosis, and anti-fibrosis, and has many important functions in wound repair. Thymosin β4 has been observed to promote the healing of various wounds, such as burns, diabetic ulcers, pressure ulcers. This paper will review the molecular structure, mechanism of wound healing promotion, pharmacokinetics, and clinical application of thymosin β4, aiming to introduce its potential in wound treatment and the shortcomings of current researches.
- Wound healing,
- Thymosin,
- Mechanism of action,
- Clinical application

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References

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Research advances on thymosin β4 in promoting wound healing

doi: 10.3760/cma.j.cn501120-20210221-00059

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Research advances on thymosin β4 in promoting wound healing

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