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Volume 38 Issue 9
Sep.  2022
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2022  >  38(9): 874-877
Chen ZH,Yu B,Ye QF,et al.Research advances on interleukin-6 in hypertrophic scar formation[J].Chin J Burns Wounds,2022,38(9):874-877.DOI: 10.3760/cma.j.cn501120-20210331-00111.
Citation: Chen ZH,Yu B,Ye QF,et al.Research advances on interleukin-6 in hypertrophic scar formation[J].Chin J Burns Wounds,2022,38(9):874-877.DOI: 10.3760/cma.j.cn501120-20210331-00111.
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Research advances on interleukin-6 in hypertrophic scar formation

doi: 10.3760/cma.j.cn501120-20210331-00111

  • Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, China

Funds:

Science and Technology Innovation Cultivation Fund of Zhongnan Hospital of Wuhan University znpy2019083

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    Abstract
  • Hypertrophic scar is a pathological repair result of excessive accumulation of extracellular matrix after skin damage, which affects the appearance and function of patients with varying degrees. The degree of scar formation is directly related to the strength of inflammatory reaction during wound healing, and excessive or prolonged inflammatory response increases the incidence of hypertrophic scars. Interleukin-6 (IL-6) is a pleiotropic cytokine that is involved in regulating the fibrotic network composed of fibroblasts, macrophages, keratinocytes, and vascular endothelial cells, and is closely related to the formation of hypertrophic scars. This article reviews the role of IL-6 and its signaling pathway in hypertrophic scar formation.

     

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