Research progress of induced pluripotent stem cells in promoting wound healing of diabetic foot ulcers

doi:10.3760/cma.j.cn501120-20210630-00230

Volume 38 Issue 9

Sep. 2022

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Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2022 > 38(9): 864-869

Gao CC,Chen JA,Wang AP.Research progress of induced pluripotent stem cells in promoting wound healing of diabetic foot ulcers[J].Chin J Burns Wounds,2022,38(9):864-869.DOI: 10.3760/cma.j.cn501120-20210630-00230.

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Research progress of induced pluripotent stem cells in promoting wound healing of diabetic foot ulcers

doi: 10.3760/cma.j.cn501120-20210630-00230

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General Program of National Natural Science Foundation of China 81770810

Received Date: 2022-06-30

Abstract

Abstract

Chronic wounds such as diabetic foot ulcers are epidemic, which bring huge burdens to both the patients and the society. However, with current treatment methods, diabetic foot ulcers often heal poorly and recur frequently, so it is urgent and important to find new and advanced therapies. Stem cell therapy has been proved by a large number of pre-clinical and clinical studies as a potential treatment for chronic wounds. However, the acquisition of stem cells often depends on invasive techniques, and immunogenicity and limited cell survival in vivo also limit the large-scale application and promotion of stem cell therapy. In the recent years, with the development and advance of induced pluripotent stem cell (iPSC) technology, it has shown a strong translational potential in the treatment of chronic wounds such as diabetic foot ulcers. This article reviews the applications and prospect of iPSCs in animal wound healing models including diabetic ulcers and limb ischemia, the limitations of their clinical application, and the methods to improve their safety.
- Diabetic foot,
- Ulcer,
- Induced pluripotent stem cells,
- Stem cell transplantation,
- Wound repair

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Research progress of induced pluripotent stem cells in promoting wound healing of diabetic foot ulcers

doi: 10.3760/cma.j.cn501120-20210630-00230

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Research progress of induced pluripotent stem cells in promoting wound healing of diabetic foot ulcers

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