Research advances on the construction of an ideal scar model <i>in vitro</i> based on innovative tissue engineering technology

Zhu Dongzhen; Yao Bin; Yan Ziqiang; Huang Sha; Fu Xiaobing

doi:10.3760/cma.j.cn501120-20210723-00257

Volume 38 Issue 10

Oct. 2022

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Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2022 > 38(10): 983-988

Zhu DZ,Yao B,Yan ZQ,et al.Research advances on the construction of an ideal scar model in vitro based on innovative tissue engineering technology[J].Chin J Burns Wounds,2022,38(10):983-988.DOI: 10.3760/cma.j.cn501120-20210723-00257.

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Research advances on the construction of an ideal scar model in vitro based on innovative tissue engineering technology

doi: 10.3760/cma.j.cn501120-20210723-00257

1.
Research Center for Wound Repair and Tissue Regeneration, Medical Innovation Research Department, the PLA General Hospital, Beijing 100048, China
2.
Institute of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China
3.
Unit 69213 of PLA, Kashgar 844900, China

Funds:

National Key Research and Development Program of China 2017YFC1103303

Youth Science Foundation of National Natural Science Foundation of China 32000969

Shanghai Wang Zhengguo Foundation for Traumatic Medicine Growth Factor Rejuvenation Plan SZYZ-TR-03

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Corresponding author: Huang Sha, Email: stellarahuang@sina.com
Received Date: 2021-07-23
Available Online: 2022-10-24

Abstract

Abstract

The scar brings a huge economic burden and creates a serious psychological shadow for patients. Although the current methods for scar treatment tend to be diversified, the treatment method that can truly achieve the goal of "perfect healing" or "scarless healing" after human skin injury is quite scarce. With the wide application of tissue engineering technologies in medicine research, technologies such as three-dimensional bioprinting, organoid culture, and organ chip technologies are constantly emerging. Disease models in vitro based on these innovative technologies showed more advantages than traditional animal disease models. The article introduces the current hotspot technologies in skin tissue engineering such as organoid culture, three-dimensional bioprinting, and organ chip technologies, focuses on summarizing the three key elements to be mastered for constructing an ideal scar model in vitro, and puts forward the future prospect of constructing an ideal scar model in vitro based on our research team's long-term experience in skin tissue repair and regeneration research.
- Cicatrix,
- Tissue engineering,
- Skin,
- Disease model

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References

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Research advances on the construction of an ideal scar model in vitro based on innovative tissue engineering technology

doi: 10.3760/cma.j.cn501120-20210723-00257

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Research advances on the construction of an ideal scar model in vitro based on innovative tissue engineering technology

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